Brian C VanderVen
  • Microbiology & Immunology Department, Cornell University, USA, USA,
Research fields
  • Microbiology
Personal information


Ph.D, Colorado State University, USA

Current position

Assistant Professor, Microbiology and Immunology, Cornell University, USA


  1. Zheng, H., Colvin, C. J., Johnson, B. K., Kirchhoff, P. D., Wilson, M., Jorgensen-Muga, K., Larsen, S. D. and Abramovitch, R. B. (2017). Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol 13(2): 218-225.
  2. Nazarova, E. V., Montague, C. R., La, T., Wilburn, K. M., Sukumar, N., Lee, W., Caldwell, S., Russell, D. G. and VanderVen, B. C. (2017). Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis. Elife 6.
  3. Tuohetahuntila, M., Molenaar, M. R., Spee, B., Brouwers, J. F., Wubbolts, R., Houweling, M., Yan, C., Du, H., VanderVen, B. C., Vaandrager, A. B. and Helms, J. B. (2017). Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation. J Biol Chem 292(30): 12436-12448.
  4. Johnson, R. M., Bai, G., DeMott, C. M., Banavali, N. K., Montague, C. R., Moon, C., Shekhtman, A., VanderVen, B. and McDonough, K. A. (2017). Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling. Mol Microbiol 105(2): 294-308.
  5. Lee, W., VanderVen, B. C., Walker, S. and Russell, D. G. (2017). Novel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis. Sci Rep 7(1): 72.
  6. VanderVen, B. C., Huang, L., Rohde, K. and Russell, D. G. (2016). The minimal unit of infection: Mtb in the macrophage. Microbiol Spectr 4(6).
  7. Liu, Y., Tan, S., Huang, L., Abramovitch, R. B., Rohde, K. H., Zimmerman, M. D., Chen, C., Dartois, V., VanderVen, B. C. and Russell, D. G. (2016). Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo. J Exp Med 213(5): 809-825.
  8. Lovewell, R. R., Sassetti, C. M. and VanderVen, B. C. (2016). Chewing the fat: lipid metabolism and homeostasis during M. tuberculosis infection. Curr Opin Microbiol 29: 30-36.
  9. VanderVen, B. C., Fahey, R. J., Lee, W., Liu, Y., Abramovitch, R. B., Memmott, C., Crowe, A. M., Eltis, L. D., Perola, E., Deininger, D. D., Wang, T., Locher, C. P. and Russell, D. G. (2015). Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment. PLoS Pathog 11(2): e1004679.
  10. Russell, D. G., Lee, W., Tan, S., Sukumar, N., Podinovskaia, M., Fahey, R. J. and VanderVen, B. C. (2014). The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell-Derived Pressures. Microbiol Spectr 2(5).
  11. Podinovskaia, M., VanderVen, B. C., Yates, R. M., Glennie, S., Fullerton, D., Mwandumba, H. C. and Russell, D. G. (2013). Dynamic quantitative assays of phagosomal function. Curr Protoc Immunol 102: Unit 14 34.
  12. Lee, W., VanderVen, B. C., Fahey, R. J. and Russell, D. G. (2013). Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. J Biol Chem 288(10): 6788-6800.
  13. Thomas, S. T., VanderVen, B. C., Sherman, D. R., Russell, D. G. and Sampson, N. S. (2011). Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism. J Biol Chem 286(51): 43668-43678.
  14. Mann, F. M., VanderVen, B. C. and Peters, R. J. (2011). Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis. Mol Microbiol 79(6): 1594-1601.
  15. Russell, D. G., VanderVen, B. C., Lee, W., Abramovitch, R. B., Kim, M. J., Homolka, S., Niemann, S. and Rohde, K. H. (2010). Mycobacterium tuberculosis wears what it eats. Cell Host Microbe 8(1): 68-76.
  16. VanderVen, B. C., Hermetter, A., Huang, A., Maxfield, F. R., Russell, D. G. and Yates, R. M. (2010). Development of a novel, cell-based chemical screen to identify inhibitors of intraphagosomal lipolysis in macrophages. Cytometry A 77(8): 751-760.
  17. Russell, D. G., VanderVen, B. C., Lee, W., Abramovitch, R. B., Kim, M. J., Homolka, S., Niemann, S. and Rohde, K. H. (2010). Mycobacterium tuberculosis wears what it eats. Cell Host Microbe 8(1): 68-76.
  18. Russell, D. G., Vanderven, B. C., Glennie, S., Mwandumba, H. and Heyderman, R. S. (2009). The macrophage marches on its phagosome: dynamic assays of phagosome function. Nat Rev Immunol 9(8): 594-600.
  19. VanderVen, B. C., Yates, R. M. and Russell, D. G. (2009). Intraphagosomal measurement of the magnitude and duration of the oxidative burst. Traffic 10(4): 372-378.
  20. Van de Walle, G. R., Peters, S. T., VanderVen, B. C., O'Callaghan, D. J. and Osterrieder, N. (2008). Equine herpesvirus type 1 (EHV-1) entry via endocytosis is facilitated by α-V integrins and an RSD motif in glycoprotein D. Journal of Virology 82(23): 11859-11868.
  21. Owens, R. M., Hsu, F. F., VanderVen, B. C., Purdy, G. E., Hesteande, E., Giannakas, P., Sacchettini, J. C., McKinney, J. D., Hill, P. J., Belisle, J. T., Butcher, B. A., Pethe, K. and Russell, D. G. (2006). M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs). Mol Microbiol 60(5): 1152-1163.
  22. VanderVen, B. C., Harder, J. D., Crick, D. C. and Belisle, J. T. (2005). Export-mediated assembly of mycobacterial glycoproteins parallels eukaryotic pathways. Science 309(5736): 941-943.
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