Tomohiko Tamura
  • Department of Immunology, Yokohama City University Graduate School of Medicine, Japan
Research fields
  • Cell biology
Personal information


Ph.D, Yokohama City University Graduate School of Medicine, Japan, 1995

Current position

Professor, Department of Immunology, Yokohama City University Graduate School of Medicine, Japan


  1. Kurotaki, D., Sasaki, H. and Tamura, T. (2017). Transcriptional control of monocyte and macrophage development. Int Immunol 29(3): 97-107.
  2. Ban, T., Sato, G. R., Nishiyama, A., Akiyama, A., Takasuna, M., Umehara, M., Suzuki, S., Ichino, M., Matsunaga, S., Kimura, A., Kimura, Y., Yanai, H., Miyashita, S., Kuromitsu, J., Tsukahara, K., Yoshimatsu, K., Endo, I., Yamamoto, T., Hirano, H., Ryo, A., Taniguchi, T. and Tamura, T. (2016). Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. Immunity 45(2): 319-332.
  3. Kurotaki, D. and Tamura, T. (2016). Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8. J Interferon Cytokine Res 36(7): 433-441.
  4. Sasaki, H., Kurotaki, D. and Tamura, T. (2016). Regulation of basophil and mast cell development by transcription factors. Allergol Int 65(2): 127-134.
  5. Sasaki, H., Kurotaki, D., Osato, N., Sato, H., Sasaki, I., Koizumi, S., Wang, H., Kaneda, C., Nishiyama, A., Kaisho, T., Aburatani, H., Morse, H. C., 3rd, Ozato, K. and Tamura, T. (2015). Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. Blood 125(2): 358-369.
  6. Kurotaki, D., Uede, T. and Tamura, T. (2015). Functions and development of red pulp macrophages. Microbiol Immunol 59(2): 55-62.
  7. Tamura, T., Kurotaki, D. and Koizumi, S. (2015). Regulation of myelopoiesis by the transcription factor IRF8. Int J Hematol 101(4): 342-351.
  8. Kurotaki, D., Yamamoto, M., Nishiyama, A., Uno, K., Ban, T., Ichino, M., Sasaki, H., Matsunaga, S., Yoshinari, M., Ryo, A., Nakazawa, M., Ozato, K. and Tamura, T. (2014). IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils. Nat Commun 5: 4978.
  9. Watanabe, T., Hotta, C., Koizumi, S., Miyashita, K., Nakabayashi, J., Kurotaki, D., Sato, G. R., Yamamoto, M., Nakazawa, M., Fujita, H., Sakai, R., Fujisawa, S., Nishiyama, A., Ikezawa, Z., Aihara, M., Ishigatsubo, Y. and Tamura, T. (2013). The transcription factor IRF8 counteracts BCR-ABL to rescue dendritic cell development in chronic myelogenous leukemia. Cancer Res 73(22): 6642-6653.
  10. Kurotaki, D., Osato, N., Nishiyama, A., Yamamoto, M., Ban, T., Sato, H., Nakabayashi, J., Umehara, M., Miyake, N., Matsumoto, N., Nakazawa, M., Ozato, K. and Tamura, T. (2013). Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood 121(10): 1839-1849.
  11. Yamamoto, M., Kato, T., Hotta, C., Nishiyama, A., Kurotaki, D., Yoshinari, M., Takami, M., Ichino, M., Nakazawa, M., Matsuyama, T., Kamijo, R., Kitagawa, S., Ozato, K. and Tamura, T. (2011). Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development. PLoS One 6(10): e25812.
  12. Savitsky, D. A., Yanai, H., Tamura, T., Taniguchi, T. and Honda, K. (2010). Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. Proc Natl Acad Sci U S A 107(22): 10154-10159.
  13. Nakajima, A., Nishimura, K., Nakaima, Y., Oh, T., Noguchi, S., Taniguchi, T. and Tamura, T. (2009). Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene. Proc Natl Acad Sci U S A 106(30): 12448-12452.
  14. Tamura, T., Smith, M., Kanno, T., Dasenbrock, H., Nishiyama, A. and Ozato, K. (2009). Inducible deposition of the histone variant H3.3 in interferon-stimulated genes. J Biol Chem 284(18): 12217-12225.
  15. Couzinet, A., Tamura, K., Chen, H. M., Nishimura, K., Wang, Z., Morishita, Y., Takeda, K., Yagita, H., Yanai, H., Taniguchi, T. and Tamura, T. (2008). A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis. Proc Natl Acad Sci U S A 105(7): 2556-2561.
  16. Tamura, T., Yanai, H., Savitsky, D. and Taniguchi, T. (2008). The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 26: 535-584.
  17. Tamura, T., Thotakura, P., Tanaka, T. S., Ko, M. S. and Ozato, K. (2005). Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Blood 106(6): 1938-1947.
  18. Tamura, T., Tailor, P., Yamaoka, K., Kong, H. J., Tsujimura, H., O'Shea, J. J., Singh, H. and Ozato, K. (2005). IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol 174(5): 2573-2581.
  19. Tamura, T., Kong, H. J., Tunyaplin, C., Tsujimura, H., Calame, K. and Ozato, K. (2003). ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells. Blood 102: 4547-4554.
  20. Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T. and Ozato, K. (2000). ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 13(2): 155-165.
  21. Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S. and Taniguchi, T. (1995). An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376(6541): 596-599.
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.