Ruth J. Muschel
  • CRUK-MRC Oxford Institute for Radiation Oncology, University of Oxford, UK
Research fields
  • Cancer biology
Personal information


Ph.D in Cell Biology, Albert Einstein College of Medicine, 1978

Current position

Professor, Dept. Oncology, Deputy Director, CRUK/MRC Oxford Institute for Radiation Therapy, University of Oxford

Publications (since 2010)

  1. Lim, S. Y., Yuzhalin, A. E., Gordon-Weeks, A. N. and Muschel, R. J. (2016). Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells. Oncogene 35(44): 5735-5745.
  2. Tapmeier, T. T., Moshnikova, A., Beech, J., Allen, D., Kinchesh, P., Smart, S., Harris, A., McIntyre, A., Engelman, D. M., Andreev, O. A., Reshetnyak, Y. K. and Muschel, R. J. (2015). The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A 112(31): 9710-9715.
  3. Lim, S. Y., Gordon-Weeks, A., Allen, D., Kersemans, V., Beech, J., Smart, S. and Muschel, R. J. (2015). Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells. Hepatology 62(2): 521-533.
  4. Im, J. H., Tapmeier, T., Balathasan, L., Gal, A., Yameen, S., Hill, S., Smart, S., Noterdaeme, O., Kelly, M., Brady, M., Fu, W., Kruse, K., Bernhard, E. J., Augustin, H. G. and Muschel, R. J. (2013). G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency. Int J Cancer 132(2): 315-326.
  5. Ferjancic, S., Gil-Bernabe, A. M., Hill, S. A., Allen, P. D., Richardson, P., Sparey, T., Savory, E., McGuffog, J. and Muschel, R. J. (2013). VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice. Blood 121(16): 3289-3297.
  6. Zhao, L., Lim, S. Y., Gordon-Weeks, A. N., Tapmeier, T. T., Im, J. H., Cao, Y., Beech, J., Allen, D., Smart, S. and Muschel, R. J. (2013). Recruitment of a myeloid cell subset (CD11b/Gr1 mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis. Hepatology 57(2): 829-839.
  7. McKee, C. M., Xu, D., Cao, Y., Kabraji, S., Allen, D., Kersemans, V., Beech, J., Smart, S., Hamdy, F., Ishkanian, A., Sykes, J., Pintile, M., Milosevic, M., van der Kwast, T., Zafarana, G., Ramnarine, V. R., Jurisica, I., Mallof, C., Lam, W., Bristow, R. G. and Muschel, R. J. (2012). Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma. J Clin Invest 122(11): 4025-4036.
  8. Gil-Bernabe, A. M., Ferjancic, S., Tlalka, M., Zhao, L., Allen, P. D., Im, J. H., Watson, K., Hill, S. A., Amirkhosravi, A., Francis, J. L., Pollard, J. W., Ruf, W. and Muschel, R. J. (2012). Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. Blood 119(13): 3164-3175.
  9. Fokas, E., Im, J. H., Hill, S., Yameen, S., Stratford, M., Beech, J., Hackl, W., Maira, S. M., Bernhard, E. J., McKenna, W. G. and Muschel, R. J. (2012). Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature. Cancer Res 72(1): 239-248.
  10. Liu, S. K., Bham, S. A., Fokas, E., Beech, J., Im, J., Cho, S., Harris, A. L. and Muschel, R. J. (2011). Delta-like ligand 4-notch blockade and tumor radiation response. J Natl Cancer Inst 103(23): 1778-1798.
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