Education

Ph.D. in Life Sciences, National Institute of Immunology, Jawaharlal Nehru University, New Delhi, India

Current Position

Associate Professor, Department of Pharmacology, Physiology, Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA

Publications (since 2005)

Journal articles

1. Brown, K. C., Perry, H. E., Lau, J. K., Jones, D. V., Pulliam, J. F., Thornhill, B. A., Crabtree, C. M., Luo, H., Chen, Y. C. and Dasgupta, P. (2013). Nicotine Induces the Up-regulation of the alpha7-Nicotinic Receptor (alpha7-nAChR) in Human Squamous Cell Lung Cancer Cells via the Sp1/GATA Protein Pathway. J Biol Chem 288(46): 33049-33059.
   
2. Lau, J.K., Brown, K.C., Thornhill, B.A., Crabtree, C.M., Dom, A.M., Carpenter, A.B., Witte, T.R, Hardman, W.E, Luo, H., Chen, Y.C., Shiflett, B.S., and Dasgupta, P. (2013) Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Cancer Research, 73, 1329-1339.
   
3. Santanam, N., Thornhill, B. A., Lau, J. K., Crabtree, C. M., Cook, C. R., Brown, K. C. and Dasgupta, P. (2012). Nicotinic acetylcholine receptor signaling in atherogenesis. Atherosclerosis 225(2): 264-273.
   
4. Brown, K. C., Lau, J. K., Dom, A. M., Witte, T. R., Luo, H., Crabtree, C. M., Shah, Y. H., Shiflett, B. S., Marcelo, A. J., Proper, N. A., Hardman, W. E., Egleton, R. D., Chen, Y. C., Mangiarua, E. I. and Dasgupta, P. (2012). MG624, an alpha7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway. Angiogenesis 15(1): 99-114.
   
5. Dasgupta, P., Rizwani, W., Pillai, S., Davis, R., Banerjee, S., Hug, K., Lloyd, M., Coppola, D., Haura, E. and Chellappan, S. P. (2011). ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. J Natl Cancer Inst 103(4): 317-333.
   
6. Dom, A. M., Buckley, A. W., Brown, K. C., Egleton, R. D., Marcelo, A. J., Proper, N. A., Weller, D. E., Shah, Y. H., Lau, J. K. and Dasgupta, P. (2011). The alpha7-nicotinic acetylcholine receptor and MMP-2/-9 pathway mediate the proangiogenic effect of nicotine in human retinal endothelial cells. Invest Ophthalmol Vis Sci 52(7): 4428-4438.
   
7. Brown, K. C., Witte, T. R., Hardman, W. E., Luo, H., Chen, Y. C., Carpenter, A. B., Lau, J. K. and Dasgupta, P. (2010). Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS One 5(4): e10243.
   
8. Egleton, R. D., Brown, K. C. and Dasgupta, P. (2009). Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseases. Pharmacol Ther 121(2): 205-223.
   
9. Dasgupta, P., Rizwani, W., Pillai, S., Kinkade, R., Kovacs, M., Rastogi, S., Banerjee, S., Carless, M., Kim, E., Coppola, D., Haura, E. and Chellappan, S. (2009). Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. Int J Cancer 124(1): 36-45.
   
10. Egleton, R. D., Brown, K. C. and Dasgupta, P. (2008). Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis. Trends Pharmacol Sci 29(3): 151-158.
    
11. Kinkade, R., Dasgupta, P., Carie, A., Pernazza, D., Carless, M., Pillai, S., Lawrence, N., Sebti, S. M. and Chellappan, S. (2008). A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice. Cancer Res 68(10): 3810-3818.
    
12. Dasgupta, P., Rastogi, S., Joshi, B., Pillai, S., Ordonez, D., Morris, M., Haura, E. and Chellappan, S. (2006) Nicotine induces cell proliferation by β-arrestin mediated activation of Src and Rb-Raf-1 pathway. J. Clin. Invest, 116, 2208-17.
    
13. Dasgupta, P., Kinkade, R., Joshi, B., DeCook, C., Haura, E. and Chellappan, S. (2006) Nicotine inhibits apoptosis induced by chemotherapeutic drugs by upregulating XIAP and survivin. Proc. Natl. Acad. Sci., USA, 103, 6332-7.
    
14. Rastogi, S., Joshi, B., Dasgupta, P*., Morris, M., Wright, K. and Chellappan, S. (2006) Prohibitin facilitates cellular senescence by recruiting specific co-repressors to inhibit E2F-target genes. Mol. Cell. Biol. 26, 4161-71.
    *equal second author
    
15. Dasgupta, P., Padmanabhan, J. and Chellappan, S. (2006). Rb function in the apoptosis and senescence of non-neuronal and neuronal cells: role in oncogenesis. Curr Mol Med 6(7): 719-729.
    
16. Kinkade, R., Dasgupta, P. and Chellappan, S. (2006) The ABCs of Targeting Raf: Novel approaches to Cancer Therapy. Current Cancer Therapy Reviews 2, 305-14.
    
17. Dasgupta, P. and Chellappan, S. P. (2006). Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story. Cell Cycle 5(20): 2324-2328.
    
18. Joshi, B., Ordonez-Ercan, D., Dasgupta, P. and Chellappan, S. (2005). Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. Oncogene 24(13): 2204-2217.
    
19. Dasgupta, P. (2005) GH-inhibitory activity of novel somatostatin agonists: potential applications in acromegaly. Curr. Med. Chem.-Immun. Endoc. & Metab. Agents, 5, 277-91.
    

Chapters in scholarly books

1. Lau, J. K., Brown, K.C., Dom, A.M and Dasgupta, P. (2012) Capsaicin: Potential Applications in Cancer Therapy. In: NUTRITION AND CANCER, Ed. P.P Claudio and R.M. Niles, 15-25, Bentham Press Inc., London, United Kingdom.
   
2. Pillai S, Dasgupta P., Chellappan SP (2009) Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. In: CHROMATIN PROTOCOLS Ed. SP Chellappan, Methods Mol. Biol., 523, 323-329. Humana Press Inc., NJ, USA
   
3. Dasgupta, P. and Chellappan, S. (2007) Chromatin immunoprecipitation assays: Molecular Analysis of chromatin modification and gene regulation, In: CANCER GENOMICS AND PROTEOMICS Ed. Paul Fischer, Methods Mol. Biol., 383, 135-152. Humana Press Inc., NJ, USA.