Shiva Kazerounian
  • Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, USA
Research fields
  • Cancer biology
Personal information


Ph.D. in Biochemistry and Molecular Biology, Department of Clinical Pharmacology, Thomas Jefferson University, 2003

Current position

Post-doctoral fellow, Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School


  1. Gerald, D., Adini, I., Shechter, S., Perruzzi, C., Varnau, J., Hopkins, B., Kazerounian, S., Kurschat, P., Blachon, S., Khedkar, S., Bagchi, M., Sherris, D., Prendergast, G. C., Klagsbrun, M., Stuhlmann, H., Rigby, A. C., Nagy, J. A. and Benjamin, L. E. (2013). RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription. Nat Commun 4: 2824.
  2. Kazerounian, S., Gerald, D., Huang, M., Chin, Y. R., Udayakumar, D., Zheng, N., O'Donnell, R. K., Perruzzi, C., Mangiante, L., Pourat, J., Phung, T. L., Bravo-Nuevo, A., Shechter, S., McNamara, S., Duhadaway, J. B., Kocher, O. N., Brown, L. F., Toker, A., Prendergast, G. C. and Benjamin, L. E. (2013). RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res 73(1): 50-61.
  3. Bravo-Nuevo, A., Sugimoto, H., Iyer, S., Fallon, Z., Lucas, J. M., Kazerounian, S., Prendergast, G. C., Kalluri, R., Shapiro, N. I. and Benjamin, L. E. (2011). RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice. Am J Pathol 178(1): 245-252.
  4. Pitari, G. M., Baksh, R. I., Harris, D. M., Li, P., Kazerounian, S. and Waldman, S. A. (2005). Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins. Cancer Res 65(23): 11129-11135.
  5. Kazerounian, S., Pitari, G. M., Shah, F. J., Frick, G. S., Madesh, M., Ruiz-Stewart, I., Schulz, S., Hajnoczky, G. and Waldman, S. A. (2005). Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins. J Pharmacol Exp Ther 314(3): 1013-1022.
  6. Tiyyagura, S. R., Kazerounian, S., Schulz, S., Waldman, S. A. and Pitari, G. M. (2004). Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP. Vitam Horm 69: 69-94. Review
  7. Ruiz-Stewart, I., Tiyyagura, S., Lin, J., Kazerounian, S., Pitari, G., Schulz, S., Martin, E., Murad, F. and Waldman, S. (2004). Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism. Proceedings of the National Academy of Sciences 101(1): 37-42.
  8. Pitari, G. M., Zingman, L. V., Hodgson, D. M., Alekseev, A. E., Kazerounian, S., Bienengraeber, M., Hajnoczky, G., Terzic, A. and Waldman, S. A. (2003). Bacterial enterotoxins are associated with resistance to colon cancer. Proc Natl Acad Sci U S A 100(5): 2695-2699.
  9.  Rathi, S., Kazerounian, S., Banwait, K., Schulz, S., Waldman, S. A. and Rattan, S. (2003). Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter. J Pharmacol Exp Ther 305(2): 615-624.
  10. Kazerounian, S., Pitari, G. M., Ruiz-Stewart, I., Schulz, S. and Waldman, S. A. (2002). Nitric oxide activation of soluble guanylyl cyclase reveals high and low affinity sites that mediate allosteric inhibition by calcium. Biochemistry 41(10): 3396-3404.
  11. Ruiz‐Stewart, I., Kazerounian, S., Pitari, G. M., Schulz, S. and Waldman, S. A. (2002). Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2‐substituted adenine nucleotides. European Journal of Biochemistry 269(8): 2186-2193.
  12. Lucas, K. A., Pitari, G. M., Kazerounian, S., Ruiz-Stewart, I., Park, J., Schulz, S., Chepenik, K. P. and Waldman, S. A. (2000). Guanylyl cyclases and signaling by cyclic GMP. Pharmacological reviews 52(3): 375-414.
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