The object in-context (OIC) task is a variant of the widely used object recognition (OR) task (Dix and Aggleton, 1999). The OIC task makes use of the fact that rodents have a natural tendency to explore novel environments and objects. The hippocampus appears to play a major role in the OIC task (much more so than in the original OR task), where animals should be able to distinguish between two familiar objects of which one is in a different context from the training trial (Ennaceur and Aggleton,1997; Bermudez-Rattoni et al., 2005; Albasser et al., 2009; Roozendaal et al., 2010; Banks et al., 2014; Bermudez-Rattoni, 2014). Recognition memory encompasses a number of additional components, such as an item's associations with its context, place, etc. (Bussey et al., 1999, 2000). Here, we describe a version of the OIC task in mice, based on earlier reports (Dix and Aggleton, 1999; Eacott and Norman, 2004; Balderas et al., 2008; Barsegyan et al., 2014; Kanatsou et al., 2015a; Kanatsou et al., 2015b).
Thanks for your further question/comment. It has been sent to the author(s) of this protocol. You will receive a notification once your question/comment is addressed again by the author(s).
Meanwhile, it would be great if you could help us to spread the word about Bio-protocol.