Education
Ph.D. in Virology, Harvard Medical School, Boston, Massachusetts, 2007
Current position
Senior Research Scientist, Biology Department, Gilead Sciences, Foster City, California
Publications (since 2005)
-
Mackman, R. L., Sangi, M., Sperandio, D., Parrish, J. P., Eisenberg, E., Perron, M., Hui, H., Zhang, L., Siegel, D., Yang, H., Saunders, O., Boojamra, C., Lee, G., Samuel, D., Babaoglu, K., Carey, A., Gilbert, B. E., Piedra, P. A., Strickley, R., Iwata, Q., Hayes, J., Stray, K., Kinkade, A., Theodore, D., Jordan, R., Desai, M. C. and Cihlar, T. (2015). Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. (Epub ahead of print)
-
Diaz-Griffero, F., Perron, M., McGee-Estrada, K., Hanna, R., Maillard, P. V., Trono, D. and Sodroski, J. (2008). A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus. Virology 378(2): 233-242.
-
Diaz-Griffero, F., Kar, A., Perron, M., Xiang, S. H., Javanbakht, H., Li, X. and Sodroski, J. (2007). Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain. J Virol 81(19): 10362-10378.
-
Ulm, J., Perron, M., Sodroski, J. and C Mulligan, R. (2007). Complex determinants within the Moloney murine leukemia virus capsid modulate susceptibility of the virus to Fv1 and Ref1-mediated restriction. Virology 363(2): 245-255.
-
Perron, M. J., Stremlau, M., Lee, M., Javanbakht, H., Song, B. and Sodroski, J. (2007). The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid. J Virol 81(5): 2138-2148.
-
Javanbakht, H., An, P., Gold, B., Petersen, D. C., O'Huigin, C., Nelson, G. W., O'Brien, S. J., Kirk, G. D., Detels, R., Buchbinder, S., Donfield, S., Shulenin, S., Song, B., Perron, M. J., Stremlau, M., Sodroski, J., Dean, M. and Winkler, C. (2006). Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology 354(1): 15-27.
-
Li, X., Li, Y., Stremlau, M., Yuan, W., Song, B., Perron, M. and Sodroski, J. (2006). Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. J Virol 80(13): 6198-6206.
-
Stremlau, M., Song, B., Javanbakht, H., Perron, M. and Sodroski, J. (2006). Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5α restriction of HIV-1. Virology 351(1): 112-120.
-
Perron, M. J., Stremlau, M. and Sodroski, J. (2006). Two surface-exposed elements of the B30. 2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5α. J Virol 80(11): 5631-5636.
-
Si, Z., Vandegraaff, N., O'Huigin, C., Song, B., Yuan, W., Xu, C., Perron, M., Li, X., Marasco, W. A., Engelman, A., Dean, M. and Sodroski, J. (2006). Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Proc Natl Acad Sci U S A 103(19): 7454-7459.
-
Stremlau, M.*, Perron, M.*, Lee, M., Li, Y., Song, B., Javanbakht, H., Diaz-Griffero, F., Anderson, D. J., Sundquist, W. I. and Sodroski, J. (2006). Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci U S A 103(14): 5514-5519. (*These authors contributed equally)
-
Song, B., Javanbakht, H., Perron, M., Park, D. H., Stremlau, M. and Sodroski, J. (2005). Retrovirus restriction by TRIM5alpha variants from Old World and New World primates. J Virol 79(7): 3930-3937.
-
Stremlau, M., Perron, M., Welikala, S. and Sodroski, J. (2005). Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction. J Virol 79(5): 3139-3145.
-
Sherman, W. A., Blouse, G. E., Perron, M. J., Tran, T., Shore, J. D. and Gafni, A. (2005). Enthalpy measurement using calorimetry shows a significant difference in potential energy between the active and latent conformations of PAI-1. Biol Chem 386(2): 111-116.