Education
Ph.D. in Immunology, University of Otago, New Zealand,1988
Current position
A/Prof and Head, Human T-cell laboratory, St. Vincent’s Institute of Medical Research, Fitzroy, Australia
Publications (since 2012)
-
Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., Armstrong, M., Powell, R. L., Reisdorph, N., Kumar, N., Elso, C. M., DeNicola, M., Bottino, R., Powers, A. C., Harlan, D. M., Kent, S. C., Mannering, S. I. and Haskins, K. (2016). Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science 351(6274): 711-714.
-
Mannering, S. I., Pathiraja, V. and Kay, T. W. (2016). The case for an autoimmune aetiology of type 1 diabetes. Clin Exp Immunol 183(1): 8-15.
-
Zhao, Y., Scott, N. A., Quah, H. S., Krishnamurthy, B., Bond, F., Loudovaris, T., Mannering, S. I., Kay, T. W. and Thomas, H. E. (2015). Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate. Eur J Immunol 45(9): 2494-2503.
-
Jenkins, M. R., Rudd-Schmidt, J. A., Lopez, J. A., Ramsbottom, K. M., Mannering, S. I., Andrews, D. M., Voskoboinik, I. and Trapani, J. A. (2015). Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time. J Exp Med 212(3): 307-317.
-
Pathiraja, V., Kuehlich, J. P., Campbell, P. D., Krishnamurthy, B., Loudovaris, T., Coates, P. T., Brodnicki, T. C., O'Connell, P. J., Kedzierska, K., Rodda, C., Bergman, P., Hill, E., Purcell, A. W., Dudek, N. L., Thomas, H. E., Kay, T. W. and Mannering, S. I. (2015). Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes. Diabetes 64(1): 172-182.
-
Wang, N., Elso, C. M., Mackin, L., Mannering, S. I., Strugnell, R. A., Wijburg, O. L. and Brodnicki, T. C. (2014). Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis. Immunogenetics 66(7-8): 501-506.
-
Lopez, J. A., Jenkins, M. R., Rudd-Schmidt, J. A., Brennan, A. J., Danne, J. C., Mannering, S. I., Trapani, J. A. and Voskoboinik, I. (2013). Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse. J Immunol 191(5): 2328-2334.
-
Prickett, S. R., Voskamp, A. L., Phan, T., Dacumos-Hill, A., Mannering, S. I., Rolland, J. M. and O'Hehir, R. E. (2013). Ara h 1 CD4+ T cell epitope-based peptides: candidates for a peanut allergy therapeutic. Clin Exp Allergy 43(6): 684-697.
-
Graham, K. L., Sutherland, R. M., Mannering, S. I., Zhao, Y., Chee, J., Krishnamurthy, B., Thomas, H. E., Lew, A. M. and Kay, T. W. (2012). Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease. Rev Diabet Stud 9(4): 148-168.
-
Broughton, S. E., Petersen, J., Theodossis, A., Scally, S. W., Loh, K. L., Thompson, A., van Bergen, J., Kooy-Winkelaar, Y., Henderson, K. N., Beddoe, T., Tye-Din, J. A., Mannering, S. I., Purcell, A. W., McCluskey, J., Anderson, R. P., Koning, F., Reid, H. H. and Rossjohn, J. (2012). Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease. Immunity 37(4): 611-621.
-
Necula, A., Chand, R., Albatat, B. and Mannering, S. I. (2012). Extraction of tissue antigens for functional assays. J Vis Exp(67).
-
Joffe, M., Necula, A. S., Chand, R., McWhinney, B. C., Krishnamurthy, B., Loudovaris, T., Goodman, D., Thomas, H. E., Kay, T. W. and Mannering, S. I. (2012). Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors. Int Immunol 24(7): 447-453.