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Patrick Calsou

Education

M.D.,  University of Toulouse, France

Ph.D. in Molecular Pharmacology of the University of Toulouse, France

Current position

Research Director at the National Institute for Health and Medical Research (INSERM)

Leader of the Group “Radiobiology & DNA Repair”, Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, France

Publications (since 2005)

  1. Cottarel, J., Frit, P., Bombarde, O., Salles, B., Negrel, A., Bernard, S., Jeggo, P. A., Lieber, M. R., Modesti, M. and Calsou, P. (2013). A noncatalytic function of the ligation complex during nonhomologous end joining. J Cell Biol 200(2): 173-186.
  2. Cheng, Q., Barboule, N., Frit, P., Gomez, D., Bombarde, O., Couderc, B., Ren, G. S., Salles, B. and Calsou, P. (2011). Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Res 39(22): 9605-9619.
  3. Romera, C., Bombarde, O., Bonnet, R., Gomez, D., Dumy, P., Calsou, P., Gwan, J. F., Lin, J. H., Defrancq, E. and Pratviel, G. (2011). Improvement of porphyrins for G-quadruplex DNA targeting. Biochimie 93(8): 1310-1317.
  4. Ye, J., Lenain, C., Bauwens, S., Rizzo, A., Saint-Leger, A., Poulet, A., Benarroch, D., Magdinier, F., Morere, J., Amiard, S., Verhoeyen, E., Britton, S., Calsou, P., Salles, B., Bizard, A., Nadal, M., Salvati, E., Sabatier, L., Wu, Y., Biroccio, A., Londono-Vallejo, A., Giraud-Panis, M. J. and Gilson, E. (2010). TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Cell 142(2): 230-242.
  5. Gomez, D., Guedin, A., Mergny, J. L., Salles, B., Riou, J. F., Teulade-Fichou, M. P. and Calsou, P. (2010). A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells. Nucleic Acids Res 38(20): 7187-7198.
  6. Bombarde, O., Boby, C., Gomez, D., Frit, P., Giraud-Panis, M. J., Gilson, E., Salles, B. and Calsou, P. (2010). TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J 29(9): 1573-1584.
  7. Britton, S., Froment, C., Frit, P., Monsarrat, B., Salles, B. and Calsou, P. (2009). Cell nonhomologous end joining capacity controls SAF-A phosphorylation by DNA-PK in response to DNA double-strand breaks inducers. Cell Cycle 8(22): 3717-3722.
  8. Britton, S., Frit, P., Biard, D., Salles, B. and Calsou, P. (2009). ARTEMIS nuclease facilitates apoptotic chromatin cleavage. Cancer Res 69(20): 8120-8126.
  9. Wu, P. Y., Frit, P., Meesala, S., Dauvillier, S., Modesti, M., Andres, S. N., Huang, Y., Sekiguchi, J., Calsou, P., Salles, B. and Junop, M. S. (2009). Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4. Mol Cell Biol 29(11): 3163-3172.
  10. Britton, S., Salles, B. and Calsou, P. (2008). c-MYC protein is degraded in response to UV irradiation. Cell Cycle 7(1): 63-70.
  11. Audebert, M., Salles, B. and Calsou, P. (2008). Effect of double-strand break DNA sequence on the PARP-1 NHEJ pathway. Biochem Biophys Res Commun 369(3): 982-988.
  12. Despras, E., Pfeiffer, P., Salles, B., Calsou, P., Kuhfittig-Kulle, S., Angulo, J. F. and Biard, D. S. (2007). Long-term XPC silencing reduces DNA double-strand break repair. Cancer Res 67(6): 2526-2534.
  13. Drouet, J., Frit, P., Delteil, C., de Villartay, J. P., Salles, B. and Calsou, P. (2006). Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends. J Biol Chem 281(38): 27784-27793.
  14. Audebert, M., Salles, B., Weinfeld, M. and Calsou, P. (2006). Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway. J Mol Biol 356(2): 257-265.
  15. Drouet, J., Delteil, C., Lefrancois, J., Concannon, P., Salles, B. and Calsou, P. (2005). DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks. J Biol Chem 280(8): 7060-7069.
Protocols by Patrick Calsou
  1. End-synapsis Assay