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Munitta Muthana

Education

Ph.D., Immunobiology of dendritic cells and their role in cancer, university of Sheffield, 2001

Current position

Non-Clinical Lecturer in the Department of Infection and Immunity, School of Medicine & Biomedical Sciences, University of Sheffield

Publications (since 2005)

  1. Muthana, M., Rodrigues, S., Chen, Y. Y., Welford, A., Hughes, R., Tazzyman, S., Essand, M., Morrow, F. and Lewis, C. E. (2013). Macrophage delivery of an oncolytic virus abolishes tumor regrowth and metastasis after chemotherapy or irradiation. Cancer Res 73(2): 490-495.
  2. Hughes R, Fang H, Muthana M, & Lewis C (2012). Role of Tumour-Associated Macrophages in the Regulation of Tumour Angiogenesis. Springer Cancer Research. Lawrence T and Hagemann, T (Eds) in Tumour-Associated Macrophages.
  3. Murdoch, C., Aziz, H. A., Fang, H. Y., Jezan, H., Musaid, R. and Muthana, M. (2011). Khat (Catha edulis) alters the phenotype and anti-microbial activity of peripheral blood mononuclear cells. J Ethnopharmacol 138(3): 780-787.
  4. Owen, M. R., Stamper, I. J., Muthana, M., Richardson, G. W., Dobson, J., Lewis, C. E. and Byrne, H. M. (2011). Mathematical modeling predicts synergistic antitumor effects of combining a macrophage-based, hypoxia-targeted gene therapy with chemotherapy. Cancer Res 71(8): 2826-2837.
  5. Muthana, M., Giannoudis, A., Scott, S. D., Fang, H. Y., Coffelt, S. B., Morrow, F. J., Murdoch, C., Burton, J., Cross, N., Burke, B., Mistry, R., Hamdy, F., Brown, N. J., Georgopoulos, L., Hoskin, P., Essand, M., Lewis, C. E. and Maitland, N. J. (2011). Use of macrophages to target therapeutic adenovirus to human prostate tumors. Cancer Res 71(5): 1805-1815. This project featured in New Understanding Of A Dreaded Disease- A Malignant Flame by Gary Stix, Scientific American (July 2008), 18, 48-55. A recent commentary on this research was also published in ‘Breaking Advances’ Highlights from Recent Cancer Literature, Cancer Research 2011;71:2807-2808.
  6. Coffelt, S. B., Chen, Y. Y., Muthana, M., Welford, A. F., Tal, A. O., Scholz, A., Plate, K. H., Reiss, Y., Murdoch, C., De Palma, M. and Lewis, C. E. (2011). Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion. J Immunol 186(7): 4183-4190.
  7. Muthana, M., Multhoff, G. and Pockley, A. G. (2010). Tumour infiltrating host cells and their significance for hyperthermia. Int J Hyperthermia 26(3): 247-255.
  8. Murdoch, C., Muthana, M., Coffelt, S. B. and Lewis, C. E. (2008). The role of myeloid cells in the promotion of tumour angiogenesis. Nature Reviews Cancer 8(8): 618-631.
  9. Muthana, M., Scott, S. D., Farrow, N., Morrow, F., Murdoch, C., Grubb, S., Brown, N., Dobson, J. and Lewis, C. E. (2008). A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Ther 15(12): 902-910.
  10. Pockley, A. G., Muthana, M. and Calderwood, S. K. (2008). The dual immunoregulatory roles of stress proteins. Trends Biochem Sci 33(2): 71-79.
  11. Pockley A.G., Muthana M. (2007). The pro- and anti-inflammatory properties of the stress protein gp96. In: Heat Shock Proteins: Potent Mediators of Inflammation and Immunity (Asea A., DeMaio A. eds.), Springer, NewYork, 309-320.
  12. Muthana M & Pockley A.G. (2007). The Immunoregulatory activities of extracellular stress proteins. In: Cell Stress Proteins (Calderwood S.K.ed.), Springer, New York, 377-395.
  13. Pockley, A. G., Fairburn, B., Mirza, S., Slack, L. K., Hopkinson, K. and Muthana, M. (2007). A non-receptor-mediated mechanism for internalization of molecular chaperones. Methods 43(3): 238-244.
  14. Murdoch, C., Muthana, M. and Lewis, C. E. (2005). Hypoxia regulates macrophage functions in inflammation. J Immunol 175(10): 6257-6263. 
Protocols by Munitta Muthana
  1. Construction of Human Monocyte Derived Macrophages Armed with Oncolytic Viruses