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Cassandra Koole

Education

Ph.D., Department of Pharmacology, Monash University, Melbourne, Australia, 2012

Current position

NHMRC CJ Martin Postdoctoral Research Fellow

Publications

  1. Koole, C., Pabreja, K., Savage, E. E., Wootten, D., Furness, S. G., Miller, L. J., Christopoulos, A. and Sexton, P. M. (2013). Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochem Soc Trans 41(1): 172-179.
  2. Harikumar, K. G., Wootten, D., Pinon, D. I., Koole, C., Ball, A. M., Furness, S. G., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. and Sexton, P. M. (2012). Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. Proc Natl Acad Sci U S A 109(45): 18607-18612.
  3. Koole, C., Wootten, D., Simms, J., Savage, E. E., Miller, L. J., Christopoulos, A. and Sexton, P. M. (2012). Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. J Biol Chem 287(6): 3659-3673.
  4. Koole, C., Wootten, D., Simms, J., Miller, L. J., Christopoulos, A. and Sexton, P. M. (2012). Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation. J Biol Chem 287(6): 3642-3658.
  5. Koole, C., Wootten, D., Simms, J., Valant, C., Miller, L. J., Christopoulos, A. and Sexton, P. M. (2011). Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation. Mol Pharmacol 80(3): 486-497.
  6. Wootten, D., Simms, J., Koole, C., Woodman, O. L., Summers, R. J., Christopoulos, A. and Sexton, P. M. (2011). Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. J Pharmacol Exp Ther 336(2): 540-550.
  7. Koole, C., Wootten, D., Simms, J., Valant, C., Sridhar, R., Woodman, O. L., Miller, L. J., Summers, R. J., Christopoulos, A. and Sexton, P. M. (2010). Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening. Mol Pharmacol 78(3): 456-465.
  8. Koole, C., Wootten, D., Sexton, P.M. cAMP accumulation assays using the ALPHAscreen® kit (PerkinElmer). Bio-protocol.org, 3(13):http://www.bio-protocol.org/wenzhang.aspx?id=805.
  9. Koole, C., Wootten, D., Sexton, P.M. pERK detection assays using the Surefire ALPHAscreen® kit (TGR Biosciences and PerkinElmer). Bio-protocol.org, 3(13):http://www.bio-protocol.org/wenzhang.aspx?id=806.
Protocols by Cassandra Koole
  1. cAMP Accumulation Assays Using the AlphaScreen® Kit (PerkinElmer)
  2. pERK Detection Assays Using the Surefire AlphaScreen® Kit (TGR Biosciences and PerkinElmer)