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Jan Joris Brosens

Education

Ph.D. in University of London, 1999
M.D in Universityof Leuven,1990

Current Position

Deputy Head, Division of Biomedical Sciences
Professor of Obstetrics & Gynaecology, University of Warwick
Honorary Consultant Obstetrician & Gynaecology, Department of Obstetrics and Gynaecology, University Hospitals Coventry and Warwickshire NHS Trust

Publications

  1. Lucas, E. S., Dyer, N. P., Murakami, K., Lee, Y. H., Chan, Y. W., Grimaldi, G., Muter, J., Brighton, P. J., Moore, J. D., Patel, G., Chan, J. K., Takeda, S., Lam, E. W., Quenby, S., Ott, S. and Brosens, J. J. (2016). Loss of Endometrial Plasticity in Recurrent Pregnancy Loss. Stem Cells 34(2): 346-356.

  2. Muter, J., Lucas, E. S., Chan, Y. W., Brighton, P. J., Moore, J. D., Lacey, L., Quenby, S., Lam, E. W. and Brosens, J. J. (2015). The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells. FASEB J 29(4): 1603-1614.
  3. Doisne, J. M., Balmas, E., Boulenouar, S., Gaynor, L. M., Kieckbusch, J., Gardner, L., Hawkes, D. A., Barbara, C. F., Sharkey, A. M., Brady, H. J., Brosens, J. J., Moffett, A. and Colucci, F. (2015). Composition, Development, and Function of Uterine Innate Lymphoid Cells. J Immunol 195(8): 3937-3945.
  4. Myatt, S. S., Kongsema, M., Man, C. W., Kelly, D. J., Gomes, A. R., Khongkow, P., Karunarathna, U., Zona, S., Langer, J. K., Dunsby, C. W., Coombes, R. C., French, P. M., Brosens, J. J. and Lam, E. W. (2014). SUMOylation inhibits FOXM1 activity and delays mitotic transition. Oncogene 33(34): 4316-4329.
  5. Brosens, J. J., Salker, M. S., Teklenburg, G., Nautiyal, J., Salter, S., Lucas, E. S., Steel, J. H., Christian, M., Chan, Y. W., Boomsma, C. M., Moore, J. D., Hartshorne, G. M., Sucurovic, S., Mulac-Jericevic, B., Heijnen, C. J., Quenby, S., Koerkamp, M. J., Holstege, F. C., Shmygol, A. and Macklon, N. S. (2014). Uterine selection of human embryos at implantation. Sci Rep 4: 3894.
  6. Murakami, K., Lee, Y. H., Lucas, E. S., Chan, Y. W., Durairaj, R. P., Takeda, S., Moore, J. D., Tan, B. K., Quenby, S., Chan, J. K., Gargett, C. E. and Brosens, J. J. (2014). Decidualization induces a secretome switch in perivascular niche cells of the human endometrium. Endocrinology 155(11): 4542-4553.
  7. Gellersen, B. and Brosens, J. J. (2014). Cyclic decidualization of the human endometrium in reproductive health and failure. Endocr Rev 35(6): 851-905.
  8. Kuroda, K., Venkatakrishnan, R., James, S., Sucurovic, S., Mulac-Jericevic, B., Lucas, E. S., Takeda, S., Shmygol, A., Brosens, J. J. and Quenby, S. (2013). Elevated periimplantation uterine natural killer cell density in human endometrium is associated with impaired corticosteroid signaling in decidualizing stromal cells. J Clin Endocrinol Metab 98(11): 4429-4437.
  9. Kuroda, K., Venkatakrishnan, R., Salker, M. S., Lucas, E. S., Shaheen, F., Kuroda, M., Blanks, A., Christian, M., Quenby, S. and Brosens, J. J. (2013). Induction of 11beta-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Mol Endocrinol 27(2): 192-202.
  10. Lam, E. W., Brosens, J. J., Gomes, A. R. and Koo, C. Y. (2013). Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer 13(7): 482-495.
  11. Salker, M. S., Nautiyal, J., Steel, J. H., Webster, Z., Sucurovic, S., Nicou, M., Singh, Y., Lucas, E. S., Murakami, K., Chan, Y. W., James, S., Abdallah, Y., Christian, M., Croy, B. A., Mulac-Jericevic, B., Quenby, S. and Brosens, J. J. (2012). Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss. PLoS One 7(12): e52252.
  12. Shah, K. M., Webber, J., Carzaniga, R., Taylor, D. M., Fusi, L., Clayton, A., Brosens, J. J., Hartshorne, G. and Christian, M. (2013). Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells. J Mol Cell Biol 5(1): 67-70.
  13. Karadedou, C. T., Gomes, A. R., Chen, J., Petkovic, M., Ho, K. K., Zwolinska, A. K., Feltes, A., Wong, S. Y., Chan, K. Y., Cheung, Y. N., Tsang, J. W., Brosens, J. J., Khoo, U. S. and Lam, E. W. (2012). FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. Oncogene 31(14): 1845-1858.
  14. Salker, M. S., Christian, M., Steel, J. H., Nautiyal, J., Lavery, S., Trew, G., Webster, Z., Al-Sabbagh, M., Puchchakayala, G., Foller, M., Landles, C., Sharkey, A. M., Quenby, S., Aplin, J. D., Regan, L., Lang, F. and Brosens, J. J. (2011). Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nat Med 17(11): 1509-1513.
  15. Grimaldi, G., Christian, M., Steel, J. H., Henriet, P., Poutanen, M. and Brosens, J. J. (2011). Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells. Mol Endocrinol 25(11): 1892-1903.
  16. Leitao, B. B., Jones, M. C. and Brosens, J. J. (2011). The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death. FASEB J 25(10): 3416-3425.
Protocols by Jan Joris Brosens
  1. Isolation and Primary Culture of Various Cell Types from Whole Human Endometrial Biopsies