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Shi Chi Leow

Shi Chi Leow


Ph.D. in Imperial College of London, UK, 2012

Current Position

Assistant Head, Biomedical Sciences Industry Partnership Office, A*STAR, Singapore


  1. Leow, S. C., Poschmann, J., Too, P. G., Yin, J., Joseph, R., McFarlane, C., Dogra, S., Shabbir, A., Ingham, P. W., Prabhakar, S., Leow, M. K., Lee, Y. S., Ng, K. L., Chong, Y. S., Gluckman, P. D. and Stunkel, W. (2016). The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. Development 143(6): 950-961.
  2. Koh, C. M., Khattar, E., Leow, S. C., Liu, C. Y., Muller, J., Ang, W. X., Li, Y., Franzoso, G., Li, S., Guccione, E. and Tergaonkar, V. (2015). Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest 125(5): 2109-2122.
  3. Li, L., Ng, D. S., Mah, W. C., Almeida, F. F., Rahmat, S. A., Rao, V. K., Leow, S. C., Laudisi, F., Peh, M. T., Goh, A. M., Lim, J. S., Wright, G. D., Mortellaro, A., Taneja, R., Ginhoux, F., Lee, C. G., Moore, P. K. and Lane, D. P. (2015). A unique role for p53 in the regulation of M2 macrophage polarization. Cell Death Differ 22(7): 1081-1093.
  4. Sukarieh, R., Joseph, R., Leow, S. C., Li, Y., Loffler, M., Aris, I. M., Tan, J. H., Teh, A. L., Chen, L., Holbrook, J. D., Ng, K. L., Lee, Y. S., Chong, Y. S., Summers, S. A., Gluckman, P. D. and Stunkel, W. (2014). Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells. Hum Reprod 29(10): 2287-2301.
  5. Ghosh, A., Saginc, G., Leow, S. C., Khattar, E., Shin, E. M., Yan, T. D., Wong, M., Zhang, Z., Li, G., Sung, W. K., Zhou, J., Chng, W. J., Li, S., Liu, E. and Tergaonkar, V. (2012). Telomerase directly regulates NF-kappaB-dependent transcription. Nat Cell Biol 14(12): 1270-1281.
  6. Mauro, C., Leow, S. C., Anso, E., Rocha, S., Thotakura, A. K., Tornatore, L., Moretti, M., De Smaele, E., Beg, A. A., Tergaonkar, V., Chandel, N. S. and Franzoso, G. (2011). NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol 13(10): 1272-1279.
  7. Bist, P., Leow, S. C., Phua, Q. H., Shu, S., Zhuang, Q., Loh, W. T., Nguyen, T. H., Zhou, J. B., Hooi, S. C. and Lim, L. H. (2011). Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-kappaB: implication in breast cancer metastasis. Oncogene 30(28): 3174-3185.
  8. Fullwood, M. J., Liu, M. H., Pan, Y. F., Liu, J., Xu, H., Mohamed, Y. B., Orlov, Y. L., Velkov, S., Ho, A., Mei, P. H., Chew, E. G., Huang, P. Y., Welboren, W. J., Han, Y., Ooi, H. S., Ariyaratne, P. N., Vega, V. B., Luo, Y., Tan, P. Y., Choy, P. Y., Wansa, K. D., Zhao, B., Lim, K. S., Leow, S. C., Yow, J. S., Joseph, R., Li, H., Desai, K. V., Thomsen, J. S., Lee, Y. K., Karuturi, R. K., Herve, T., Bourque, G., Stunnenberg, H. G., Ruan, X., Cacheux-Rataboul, V., Sung, W. K., Liu, E. T., Wei, C. L., Cheung, E. and Ruan, Y. (2009). An oestrogen-receptor-alpha-bound human chromatin interactome. Nature 462(7269): 58-64.
Protocols by Shi Chi Leow
  1. Isolation and Culture of Human Adipose-derived Stem Cells from Subcutaneous and Visceral White Adipose Tissue Compartments