Pierre-Damien Denechaud

Education

Ph.D in Energetic Metabolism and Nutritional Regulations, University of Paris Diderot, France, 2009

Current position

Postdoctoral fellow, Department of Physiology, University of Lausanne, Switzerland

Publications (2008)

1. Rabhi, N., Denechaud, P. D., Gromada, X., Hannou, S. A., Zhang, H., Rashid, T., Salas, E., Durand, E., Sand, O., Bonnefond, A., Yengo, L., Chavey, C., Bonner, C., Kerr-Conte, J., Abderrahmani, A., Auwerx, J., Fajas, L., Froguel, P. and Annicotte, J. S. (2016). KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell Rep 15(5): 1051-1061.

2. Lagarrigue, S., Lopez-Mejia, I. C., Denechaud, P. D., Escote, X., Castillo-Armengol, J., Jimenez, V., Chavey, C., Giralt, A., Lai, Q., Zhang, L., Martinez-Carreres, L., Delacuisine, B., Annicotte, J. S., Blanchet, E., Hure, S., Abella, A., Tinahones, F. J., Vendrell, J., Dubus, P., Bosch, F., Kahn, C. R. and Fajas, L. (2016). CDK4 is an essential insulin effector in adipocytes. J Clin Invest 126(1): 335-348.

3. Denechaud, P. D., Lopez-Mejia, I. C., Giralt, A., Lai, Q., Blanchet, E., Delacuisine, B., Nicolay, B. N., Dyson, N. J., Bonner, C., Pattou, F., Annicotte, J. S. and Fajas, L. (2016). E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. J Clin Invest 126(1): 137-150.

4. Gougelet, A., Torre, C., Veber, P., Sartor, C., Bachelot, L., Denechaud, P. D., Godard, C., Moldes, M., Burnol, A. F., Dubuquoy, C., Terris, B., Guillonneau, F., Ye, T., Schwarz, M., Braeuning, A., Perret, C. and Colnot, S. (2014). T-cell factor 4 and beta-catenin chromatin occupancies pattern zonal liver metabolism in mice. Hepatology 59(6): 2344-2357.

5. Benhamed, F., Denechaud, P. D., Lemoine, M., Robichon, C., Moldes, M., Bertrand-Michel, J., Ratziu, V., Serfaty, L., Housset, C., Capeau, J., Girard, J., Guillou, H. and Postic, C. (2012). The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J Clin Invest 122(6): 2176-2194.

6. Mihaylova, M. M., Vasquez, D. S., Ravnskjaer, K., Denechaud, P. D., Yu, R. T., Alvarez, J. G., Downes, M., Evans, R. M., Montminy, M. and Shaw, R. J. (2011). Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145(4): 607-621.

7. Denechaud, P. D., Girard, J. and Postic, C. (2008). Carbohydrate responsive element binding protein and lipid homeostasis. Curr Opin Lipidol 19(3): 301-306.

8. Denechaud, P. D., Bossard, P., Lobaccaro, J. M., Millatt, L., Staels, B., Girard, J. and Postic, C. (2008). ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest 118(3): 956-964.

9. Denechaud, P. D., Dentin, R., Girard, J. and Postic, C. (2008). Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett 582(1): 68-73.

Protocols by Pierre-Damien Denechaud

1. Determination of the Glycolysis and Lipogenesis in Culture of Hepatocytes