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J. Pablo Radicella

Education

Ph.D. in Biological Chemistry, University of Buenos Aires, 1986

Current position

Deputy Director of the Institute of Cellular and Molecular Radiobiology, Commissariat à l'Energie Atomique, Fontenay aux Roses, France (2010-present)

Publications

  1. Damke, P. P., Dhanaraju, R., Marsin, S., Radicella, J. P. and Rao, D. N. (2016). Mutations in the nucleotide binding and hydrolysis domains of Helicobacter pylori MutS2 lead to altered biochemical activities and inactivation of its in vivo function. BMC Microbiol 16(1): 14.
  2. de Melo, J. T., de Souza Timoteo, A. R., Lajus, T. B., Brandao, J. A., de Souza-Pinto, N. C., Menck, C. F., Campalans, A., Radicella, J. P., Vessoni, A. T., Muotri, A. R. and Agnez-Lima, L. F. (2016). XPC deficiency is related to APE1 and OGG1 expression and function. Mutat Res 784-785: 25-33.
  3. Sonzogni, S. V., Ogara, M. F., Castillo, D. S., Sirkin, P. F., Radicella, J. P. and Canepa, E. T. (2015). Nuclear translocation of p19INK4d in response to oxidative DNA damage promotes chromatin relaxation. Mol Cell Biochem 398(1-2): 63-72.
  4. Castillo, D. S., Campalans, A., Belluscio, L. M., Carcagno, A. L., Radicella, J. P., Canepa, E. T. and Pregi, N. (2015). E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells. Cell Cycle 14(8): 1300-1314.
  5. Bravard, A., Auvre, F., Fantini, D., Bernardino-Sgherri, J., Sissoeff, L., Daynac, M., Xu, Z., Etienne, O., Dehen, C., Comoy, E., Boussin, F. D., Tell, G., Deslys, J. P. and Radicella, J. P. (2015). The prion protein is critical for DNA repair and cell survival after genotoxic stress. Nucleic Acids Res 43(2): 904-916.
  6. Campalans, A., Moritz, E., Kortulewski, T., Biard, D., Epe, B. and Radicella, J. P. (2015). Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stress. Mol Cell Biol 35(9): 1648-1658.
  7. Damke, P. P., Dhanaraju, R., Marsin, S., Radicella, J. P. and Rao, D. N. (2015). The nuclease activities of both the Smr domain and an additional LDLK motif are required for an efficient anti-recombination function of Helicobacter pylori MutS2. Mol Microbiol 96(6): 1240-1256.
  8. Guyon, L., Lajaunie, C., Fer, F., Bhajun, R., Sulpice, E., Pinna, G., Campalans, A., Radicella, J. P., Rouillier, P., Mary, M., Combe, S., Obeid, P., Vert, J. P. and Gidrol, X. (2015). Phi-score: A cell-to-cell phenotypic scoring method for sensitive and selective hit discovery in cell-based assays. Sci Rep 5: 14221.
  9. Moritz, E., Pauly, K., Bravard, A., Hall, J., Radicella, J. P. and Epe, B. (2014). hOGG1-Cys326 variant cells are hypersensitive to DNA repair inhibition by nitric oxide. Carcinogenesis 35(6): 1426-1433.
  10. Fantini, D., Moritz, E., Auvre, F., Amouroux, R., Campalans, A., Epe, B., Bravard, A. and Radicella, J. P. (2013). Rapid inactivation and proteasome-mediated degradation of OGG1 contribute to the synergistic effect of hyperthermia on genotoxic treatments. DNA Repair (Amst) 12(3): 227-237.
  11. Sedletska, Y., Radicella, J. P. and Sage, E. (2013). Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clusters. Nucleic Acids Res 41(20): 9339-9348.
  12. Campalans, A., Kortulewski, T., Amouroux, R., Menoni, H., Vermeulen, W. and Radicella, J. P. (2013). Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair. Nucleic Acids Res 41(5): 3115-3129.
  13. Garcia-Ortiz, M. V., Marsin, S., Arana, M. E., Gasparutto, D., Guerois, R., Kunkel, T. A. and Radicella, J. P. (2011). Unexpected role for Helicobacter pylori DNA polymerase I as a source of genetic variability. PLoS Genet 7(6): e1002152.
  14. Orillard, E., Radicella, J. P. and Marsin, S. (2011). Biochemical and cellular characterization of Helicobacter pylori RecA, a protein with high-level constitutive expression. J Bacteriol 193(23): 6490-6497.
  15. Bravard, A., Campalans, A., Vacher, M., Gouget, B., Levalois, C., Chevillard, S. and Radicella, J. P. (2010). Inactivation by oxidation and recruitment into stress granules of hOGG1 but not APE1 in human cells exposed to sub-lethal concentrations of cadmium. Mutat Res 685(1-2): 61-69.
  16. Bergeron, F., Auvre, F., Radicella, J. P. and Ravanat, J. L. (2010). HO* radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases. Proc Natl Acad Sci U S A 107(12): 5528-5533.
  17. Amouroux, R., Campalans, A., Epe, B. and Radicella, J. P. (2010). Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions. Nucleic Acids Res 38(9): 2878-2890.
  18. Marsin, S., Lopes, A., Mathieu, A., Dizet, E., Orillard, E., Guerois, R. and Radicella, J. P. (2010). Genetic dissection of Helicobacter pylori AddAB role in homologous recombination. FEMS Microbiol Lett 311(1): 44-50.
  19. Fantini, D., Vascotto, C., Marasco, D., D'Ambrosio, C., Romanello, M., Vitagliano, L., Pedone, C., Poletto, M., Cesaratto, L., Quadrifoglio, F., Scaloni, A., Radicella, J. P. and Tell, G. (2010). Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions. Nucleic Acids Res 38(22): 8239-8256.
  20. Vascotto, C., Fantini, D., Romanello, M., Cesaratto, L., Deganuto, M., Leonardi, A., Radicella, J. P., Kelley, M. R., D'Ambrosio, C., Scaloni, A., Quadrifoglio, F. and Tell, G. (2009). APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Mol Cell Biol 29(7): 1834-1854.
  21. Bravard, A., Vacher, M., Moritz, E., Vaslin, L., Hall, J., Epe, B. and Radicella, J. P. (2009). Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity. Cancer Res 69(8): 3642-3649.
  22. Bigot, K., Leemput, J., Vacher, M., Campalans, A., Radicella, J. P., Lacassagne, E., Provost, A., Masson, C., Menasche, M. and Abitbol, M. (2009). Expression of 8-oxoguanine DNA glycosylase (Ogg1) in mouse retina. Mol Vis 15: 1139-1152.
  23. Eiberger, W., Volkmer, B., Amouroux, R., Dherin, C., Radicella, J. P. and Epe, B. (2008). Oxidative stress impairs the repair of oxidative DNA base modifications in human skin fibroblasts and melanoma cells. DNA Repair (Amst) 7(6): 912-921.
  24. Marsin, S., Mathieu, A., Kortulewski, T., Guerois, R. and Radicella, J. P. (2008). Unveiling novel RecO distant orthologues involved in homologous recombination. PLoS Genet 4(8): e1000146.
  25. Campalans, A., Amouroux, R., Bravard, A., Epe, B. and Radicella, J. P. (2007). UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles. J Cell Sci 120(Pt 1): 23-32.
  26. Nazarkina Zh, K., Khodyreva, S. N., Marsin, S., Radicella, J. P. and Lavrik, O. I. (2007). Study of interaction of XRCC1 with DNA and proteins of base excision repair by photoaffinity labeling technique. Biochemistry (Mosc) 72(8): 878-886.
  27. Bravard, A., Vacher, M., Gouget, B., Coutant, A., de Boisferon, F. H., Marsin, S., Chevillard, S. and Radicella, J. P. (2006). Redox regulation of human OGG1 activity in response to cellular oxidative stress. Mol Cell Biol 26(20): 7430-7436.
  28. Mathieu, A., O'Rourke, E. J. and Radicella, J. P. (2006). Helicobacter pylori genes involved in avoidance of mutations induced by 8-oxoguanine. J Bacteriol 188(21): 7464-7469.
  29. Sossou, M., Flohr-Beckhaus, C., Schulz, I., Daboussi, F., Epe, B. and Radicella, J. P. (2005). APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability. Nucleic Acids Res 33(1): 298-306.
  30. Pinto, A. V., Mathieu, A., Marsin, S., Veaute, X., Ielpi, L., Labigne, A. and Radicella, J. P. (2005). Suppression of homologous and homeologous recombination by the bacterial MutS2 protein. Mol Cell 17(1): 113-120.
  31. Campalans, A., Marsin, S., Nakabeppu, Y., O'Connor T, R., Boiteux, S. and Radicella, J. P. (2005). XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair. DNA Repair (Amst) 4(7): 826-835.
  32. Araneda, S., Pelloux, S., Radicella, J. P., Angulo, J., Kitahama, K., Gysling, K. and Forray, M. I. (2005). 8-oxoguanine DNA glycosylase, but not Kin17 protein, is translocated and differentially regulated by estrogens in rat brain cells. Neuroscience 136(1): 135-146.
Protocols by J. Pablo Radicella
  1. Laser Microirradiation and Temporal Analysis of XRCC1 Recruitment to Single-strand DNA Breaks