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Jiří Fajkus


Ph.D. in Biophysics, Czech Academy of Sciences, Brno, Czech Republic, 1992

Current position

Full Professor of Mol. Biol. & Genetics, Masaryk University, Brno, Czech Republic (2010-present)
Head of the Mendel Centre for Plant Genomics and Proteomics, CEITEC Masaryk University, Brno, Czech Republic
Head of the Laboratory of Functional Genomics and Proteomics, National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic

Publications (since 2010)

  1. Peška, V., Fajkus, P., Fojtová, M., Dvořáčková, M., Hapala, J., Dvořáček, V., Polanská, P., Leitch, A. R., Sýkorová, E. and Fajkus, J. (2015). Characterisation of an unusual telomere motif (TTTTTTAGGG)n in the plant Cestrum elegans (Solanaceae), a species with a large genome. Plant J 82(4): 644-654.
  2. Muchova, V., Amiard, S., Mozgova, I., Dvorackova, M., Gallego, M. E., White, C. and Fajkus, J. (2015). Homology-dependent repair is involved in 45S rDNA loss in plant CAF-1 mutants. Plant J 81(2): 198-209.
  3. Dvořáčková, M., Fojtová, M. and Fajkus, J. (2015). Chromatin dynamics of plant telomeres and ribosomal genes. Plant J 83(1): 18-37.
  4. Schrumpfova, P. P., Vychodilova, I., Dvorackova, M., Majerska, J., Dokladal, L., Schorova, S. and Fajkus, J. (2014). Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase. Plant J 77(5): 770-781.
  5. Ogrocka, A., Polanska, P., Majerova, E., Janeba, Z., Fajkus, J. and Fojtova, M. (2014). Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants. Nucleic Acids Res 42(5): 2919-2931.
  6. Majerova, E., Mandakova, T., Vu, G. T., Fajkus, J., Lysak, M. A. and Fojtova, M. (2014). Chromatin features of plant telomeric sequences at terminal vs. internal positions. Front Plant Sci 5: 593.
  7. Fojtova, M. and Fajkus, J. (2014). Epigenetic regulation of telomere maintenance. Cytogenet Genome Res 143(1-3): 125-135.
  8. Zachova, D., Fojtova, M., Dvorackova, M., Mozgova, I., Lermontova, I., Peska, V., Schubert, I., Fajkus, J. and Sykorova, E. (2013). Structure-function relationships during transgenic telomerase expression in Arabidopsis. Physiol Plant 149(1): 114-126.
  9. Pontvianne, F., Blevins, T., Chandrasekhara, C., Mozgova, I., Hassel, C., Pontes, O. M., Tucker, S., Mokros, P., Muchova, V., Fajkus, J. and Pikaard, C. S. (2013). Subnuclear partitioning of rRNA genes between the nucleolus and nucleoplasm reflects alternative epiallelic states. Genes Dev 27(14): 1545-1550.
  10. Kruta, M., Balek, L., Hejnova, R., Dobsakova, Z., Eiselleova, L., Matulka, K., Barta, T., Fojtik, P., Fajkus, J., Hampl, A., Dvorak, P. and Rotrekl, V. (2013). Decrease in abundance of apurinic/apyrimidinic endonuclease causes failure of base excision repair in culture-adapted human embryonic stem cells. Stem Cells 31(4): 693-702.
  11. Jaske, K., Mokros, P., Mozgova, I., Fojtova, M. and Fajkus, J. (2013). A telomerase-independent component of telomere loss in chromatin assembly factor 1 mutants of Arabidopsis thaliana. Chromosoma 122(4): 285-293.
  12. Fulneckova, J., Sevcikova, T., Fajkus, J., Lukesova, A., Lukes, M., Vlcek, C., Lang, B. F., Kim, E., Elias, M. and Sykorova, E. (2013). A broad phylogenetic survey unveils the diversity and evolution of telomeres in eukaryotes. Genome Biol Evol 5(3): 468-483.
  13. Cincarova, L., Zdrahal, Z. and Fajkus, J. (2013). New perspectives of valproic acid in clinical practice. Expert Opin Investig Drugs 22(12): 1535-1547.
  14. Visacka, K., Hofr, C., Willcox, S., Necasova, I., Pavlouskova, J., Sepsiova, R., Wimmerova, M., Simonicova, L., Nosek, J., Fajkus, J., Griffith, J. D. and Tomaska, L. (2012). Synergism of the two Myb domains of Tay1 protein results in high affinity binding to telomeres. J Biol Chem 287(38): 32206-32215.
  15. Sykorova, E., Fulneckova, J., Mokros, P., Fajkus, J., Fojtova, M. and Peska, V. (2012). Three TERT genes in Nicotiana tabacum. Chromosome Res 20(4): 381-394.
  16. Polanska, E., Dobsakova, Z., Dvorackova, M., Fajkus, J. and Stros, M. (2012). HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction. Chromosoma 121(4): 419-431.
  17. Ogrocka, A., Sykorova, E., Fajkus, J. and Fojtova, M. (2012). Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment. J Exp Bot 63(11): 4233-4241.
  18. Fulneckova, J., Hasikova, T., Fajkus, J., Lukesova, A., Elias, M. and Sykorova, E. (2012). Dynamic evolution of telomeric sequences in the green algal order Chlamydomonadales. Genome Biol Evol 4(3): 248-264.
  19. Cincarova, L., Lochmanova, G., Novakova, K., Sultesova, P., Konecna, H., Fajkusova, L., Fajkus, J. and Zdrahal, Z. (2012). A combined approach for the study of histone deacetylase inhibitors. Mol Biosyst 8(11): 2937-2945.
  20. Schrumpfova, P. P., Fojtova, M., Mokros, P., Grasser, K. D. and Fajkus, J. (2011). Role of HMGB proteins in chromatin dynamics and telomere maintenance in Arabidopsis thaliana. Curr Protein Pept Sci 12(2): 105-111.
  21. Peska, V., Schrumpfova, P. P. and Fajkus, J. (2011). Using the telobox to search for plant telomere binding proteins. Curr Protein Pept Sci 12(2): 75-83.
  22. Majerska, J., Sykorova, E. and Fajkus, J. (2011). Non-telomeric activities of telomerase. Mol Biosyst 7(4): 1013-1023.
  23. Majerova, E., Fojtova, M., Mozgova, I., Bittova, M. and Fajkus, J. (2011). Hypomethylating drugs efficiently decrease cytosine methylation in telomeric DNA and activate telomerase without affecting telomere lengths in tobacco cells. Plant Mol Biol 77(4-5): 371-380.
  24. Fojtova, M., Peska, V., Dobsakova, Z., Mozgova, I., Fajkus, J. and Sykorova, E. (2011). Molecular analysis of T-DNA insertion mutants identified putative regulatory elements in the AtTERT gene. J Exp Bot 62(15): 5531-5545.
  25. Majerova, E., Fojtova, M., Mandakova, T. and Fajkus, J. (2011). Methylation of plant telomeric DNA: what do the results say? Plant Mol Biol 77: 533-536.
  26. Fajkus, J. (2011). Proteins in signalling pathways and chromosome stability in plants. Curr Protein Pept Sci 12(2): 74.
  27. Mozgova, I., Mokros, P. and Fajkus, J. (2010). Dysfunction of chromatin assembly factor 1 induces shortening of telomeres and loss of 45S rDNA in Arabidopsis thaliana. Plant Cell 22(8): 2768-2780.
  28. Jerabkova, B., Marek, J., Buckova, H., Kopeckova, L., Vesely, K., Valickova, J., Fajkus, J. and Fajkusova, L. (2010). Keratin mutations in patients with epidermolysis bullosa simplex: correlations between phenotype severity and disturbance of intermediate filament molecular structure. Br J Dermatol 162(5): 1004-1013.
  29. Chester, M., Sykorova, E., Fajkus, J. and Leitch, A. R. (2010). Single integration and spread of a Copia-like sequence nested in rDNA intergenic spacers of Allium cernuum (Alliaceae). Cytogenet Genome Res 129(1-3): 35-46.
  30. Goldmann, R., Tichy, L., Freiberger, T., Zapletalova, P., Letocha, O., Soska, V., Fajkus, J. and Fajkusova, L. (2010). Genomic characterization of large rearrangements of the LDLR gene in Czech patients with familial hypercholesterolemia. BMC Med Genet 11: 115.
  31. Fojtova, M., Wong, J. T., Dvorackova, M., Yan, K. T., Sykorova, E. and Fajkus, J. (2010). Telomere maintenance in liquid crystalline chromosomes of dinoflagellates. Chromosoma 119(5): 485-493.
  32. Dvorackova, M., Rossignol, P., Shaw, P. J., Koroleva, O. A., Doonan, J. H. and Fajkus, J. (2010). AtTRB1, a telomeric DNA-binding protein from Arabidopsis, is concentrated in the nucleolus and shows highly dynamic association with chromatin. Plant J 61(4): 637-649.

Protocols by Jiří Fajkus
  1. Terminal Restriction Fragments (TRF) Method to Analyze Telomere Lengths