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Miloslava Fojtová

Education

Ph.D. in Biophysics, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, 2000

Current position

Principal investigator, Laboratory of Chromatin Molecular Complexes, Mendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology (CEITEC) and Faculty of Science, Masaryk University, Brno, Czech Republic

Publications (since 2005)

  1. Tran, T. D., Cao, H. X., Jovtchev, G., Neumann, P., Novák, P., Fojtová, M., Vu, G. T., Macas, J., Fajkus, J., Schubert, I. and Fuchs, J. (2015). Centromere and telomere sequence alterations reflect the rapid genome evolution within the carnivorous plant genus Genlisea. Plant J.
  2. Jankowska, M., Fuchs, J., Klocke, E., Fojtová, M., Polanská, P., Fajkus, J., Schubert, V. and Houben, A. (2015). Holokinetic centromeres and efficient telomere healing enable rapid karyotype evolution. Chromosoma.
  3. Fojtová, M., Sýkorová, E., Najdekrová, L., Polanská, P., Zachová, D., Vagnerová, R., Angelis, K. J. and Fajkus, J. (2015). Telomere dynamics in the lower plant Physcomitrella patens. Plant Mol Biol 87(6): 591-601.
  4. Peška, V., Fajkus, P., Fojtová, M., Dvořáčková, M., Hapala, J., Dvořáček, V., Polanská, P., Leitch, A. R., Sýkorová, E. and Fajkus, J. (2015). Characterisation of an unusual telomere motif (TTTTTTAGGG)n in the plant Cestrum elegans (Solanaceae), a species with a large genome. Plant J 82(4): 644-654.
  5. Dvořáčková, M., Fojtová, M. and Fajkus, J. (2015). Chromatin dynamics of plant telomeres and ribosomal genes. Plant J 83(1): 18-37.
  6. Majerová, E., Mandáková, T., Vu, G. T., Fajkus, J., Lysák, M. A. and Fojtová, M. (2014). Chromatin features of plant telomeric sequences at terminal vs. internal positions. Front Plant Sci 5: 593.
  7. Fojtová, M. and Fajkus, J. (2014). Epigenetic regulation of telomere maintenance. Cytogenet Genome Res 143(1-3): 125-135.
  8. Ogrocká, A., Polanská, P., Majerová, E., Janeba, Z., Fajkus, J. and Fojtová, M. (2014). Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants. Nucleic Acids Res 42(5): 2919-2931.
  9. Sýkorová, E., Fojtová, M. and Peška, V. (2013). A polymerase chain reaction-based approach for evaluation of telomere-associated sequences and interstitial telomeric sequences. Anal Biochem 439(1): 8-10.
  10. Jaške, K., Mokroš, P., Mozgová, I., Fojtová, M. and Fajkus, J. (2013). A telomerase-independent component of telomere loss in chromatin assembly factor 1 mutants of Arabidopsis thaliana. Chromosoma 122(4): 285-293.
  11. Ševčíková, T., Bišová, K., Fojtová, M., Lukešová, A., Hrčková, K. and Sýkorová, E. (2013). Completion of cell division is associated with maximum telomerase activity in naturally synchronized cultures of the green alga Desmodesmus quadricauda. FEBS Lett 587(6): 743-748.
  12. Legartová, S., Jugová, A., Stixová, L., Kozubek, S., Fojtová, M., Zdráhal, Z., Lochmanová, G. and Bártová, E. (2013). Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin. Biochimie 95(2): 167-179.
  13. Zachová, D., Fojtová, M., Dvořáčková, M., Mozgová, I., Lermontova, I., Peška, V., Schubert, I., Fajkus, J. and Sýkorová, E. (2013). Structure-function relationships during transgenic telomerase expression in Arabidopsis. Physiol Plant 149(1): 114-126.
  14. Sýkorová, E., Fulnečková, J., Mokroš, P., Fajkus, J., Fojtová, M. and Peška, V. (2012). Three TERT genes in Nicotiana tabacum. Chromosome Res 20(4): 381-394.
  15. Ogrocká, A., Sýkorová, E., Fajkus, J. and Fojtová, M. (2012). Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment. J Exp Bot 63(11): 4233-4241.
  16. Khaitová, L. C., Fojtová, M., Křížová, K., Lunerová, J., Fulneček, J., Depicker, A. and Kovařík, A. (2011). Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing. Epigenetics 6(5): 650-660.
  17. Majerová, E., Fojtová, M., Mozgová, I., Bittová, M. and Fajkus, J. (2011). Hypomethylating drugs efficiently decrease cytosine methylation in telomeric DNA and activate telomerase without affecting telomere lengths in tobacco cells. Plant Mol Biol 77(4-5): 371-380.
  18. Majerová, E., Fojtová, M., Mandáková, T. and Fajkus, J. (2011). Methylation of plant telomeric DNA: what do the results say? Plant Mol Biol 77: 533-536.
  19. Schrumpfová, P. P., Fojtová, M., Mokroš, P., Grasser, K. D. and Fajkus, J. (2011). Role of HMGB proteins in chromatin dynamics and telomere maintenance in Arabidopsis thaliana. Curr Protein Pept Sci 12(2): 105-111.
  20. Fojtová, M., Peška, V., Dobšáková, Z., Mozgová, I., Fajkus, J. and Sýkorová, E. (2011). Molecular analysis of T-DNA insertion mutants identified putative regulatory elements in the AtTERT gene. J Exp Bot 62(15): 5531-5545.
  21. Pivoňková, H., Horáková, P., Fojtová, M. and Fojta, M. (2010). Direct voltammetric analysis of DNA modified with enzymatically incorporated 7-deazapurines. Anal Chem 82(16): 6807-6813.
  22. Fojtová, M., Wong, J. T., Dvořáčková, M., Yan, K. T., Sýkorová, E. and Fajkus, J. (2010). Telomere maintenance in liquid crystalline chromosomes of dinoflagellates. Chromosoma 119(5): 485-493.
  23. Humpolíková-Adámková, L., Kovařík, J., Dušek, L., Lauerová, L., Boudný, V., Fait, V., Fojtová, M., Krejčí, E. and Kovařík, A. (2009). Interferon-alpha treatment may negatively influence disease progression in melanoma patients by hyperactivation of STAT3 protein. Eur J Cancer 45(7): 1315-1323.
  24. Křížová, K., Fojtová, M., Depicker, A. and Kovařík, A. (2009). Cell culture-induced gradual and frequent epigenetic reprogramming of invertedly repeated tobacco transgene epialleles. Plant Physiol 149(3): 1493-1504.
  25. Horáková-Brázdilová, P., Fojtová, M., Vytřas, K. and Fojta, M. (2008). Enzyme-linked electrochemical detection of PCR amplified nucleotide sequences using disposable screen-printed sensors. Application in gene expression monitoring. Sensors 8: 193-210.
  26. Lunerová-Bedřichová, J., Bleys, A., Fojtová, M., Khaitová, L., Depicker, A. and Kovařík, A. (2008). Trans-generation inheritance of methylation patterns in a tobacco transgene following a post-transcriptional silencing event. Plant J 54(6): 1049-1062.
  27. Fojtová, M., Piskala, A., Votruba, I., Otmar, M., Bártová, E. and Kovařík, A. (2007). Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer. Pharmacol Res 55(1): 16-22.
  28. Fojtová, M., Boudný, V., Kovařík, A., Lauerová, L., Adámková, L., Součková, K., Jarkovský, J. and Kovařík, J. (2007). Development of IFN-gamma resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells. Br J Cancer 97(2): 231-237.
  29. Fojtová, M., Bleys, A., Bedřichová, J., Van Houdt, H., Křížová, K., Depicker, A. and Kovařík, A. (2006). The trans-silencing capacity of invertedly repeated transgenes depends on their epigenetic state in tobacco. Nucleic Acids Res 34(8): 2280-2293.
  30. Koukalová, B., Fojtová, M., Lim, K. Y., Fulneček, J., Leitch, A. R. and Kovařík, A. (2005). Dedifferentiation of tobacco cells is associated with ribosomal RNA gene hypomethylation, increased transcription, and chromatin alterations. Plant Physiol 139(1): 275-286.
  31. Kovařík, A., Fojtová, M., Boudný, V., Adámková, L., Lauerová, L. and Kovařík, J. (2005). Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines. Melanoma Res 15(6): 481-488.
  32. Fojta, M., Fojtová, M., Havran, L., Pivoňková, H., Dorčák, V. and Šestáková, I. (2005). Electrochemical monitoring of phytochelatin accumulation in Nicotiana tabacum cells exposed to sub-cytotoxic and cytotoxic levels of cadmium. Anal Chim Acta 558: 171-178.
Protocols by Miloslava Fojtová
  1. Terminal Restriction Fragments (TRF) Method to Analyze Telomere Lengths