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Joseph C. Chen

Education

Ph.D. in Endocrinology and Animal Bioscience, Rutgers University, Graduate School-New Brunswick, 2010

Current position

Senior Scientist, Department of Research and Development, Siemens Clinical Labs (2015-present)

Publications

  1. Smith-McCune, K., Chen, J. C., Greenblatt, R. M., Shanmugasundaram, U., Shacklett, B. L., Hilton, J. F., Johnson, B., Irwin, J. C. and Giudice, L. C. (2015). Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study. PLoS One 10(7): e0129769.
  2. Piltonen, T. T.*, Chen, J. C.*, Khatun, M., Kangasniemi, M., Liakka, A., Spitzer, T., Tran, N., Huddleston, H., Irwin, J. C. and Giudice, L. C. (2015). Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro. Hum Reprod 30(5): 1203-1215.( * authors contributed equally to the work)
  3. Harvey, C. N., Chen, J. C., Bagnell, C. A. and Uzumcu, M. (2015). Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors alpha and beta in the rat granulosa cell in vitro. Reprod Toxicol 51: 72-78.
  4. Chen, J. C., Johnson, B. A., Erikson, D. W., Piltonen, T. T., Barragan, F., Chu, S., Kohgadai, N., Irwin, J. C., Greene, W. C., Giudice, L. C. and Roan, N. R. (2014). Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod 29(6): 1255-1270.
  5. Piltonen, T. T., Chen, J., Erikson, D. W., Spitzer, T. L., Barragan, F., Rabban, J. T., Huddleston, H., Irwin, J. C. and Giudice, L. C. (2013). Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential. J Clin Endocrinol Metab 98(9): 3765-3775.
  6. Chen, J. C., Erikson, D. W., Piltonen, T. T., Meyer, M. R., Barragan, F., McIntire, R. H., Tamaresis, J. S., Vo, K. C., Giudice, L. C. and Irwin, J. C. (2013). Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production. Fertil Steril 100(4): 1132-1143.
  7. Hyde, L. A., Zhang, Q., Del Vecchio, R. A., Leach, P. T., Cohen-Williams, M. E., Chen, L., Wong, G. T., McHugh, N. A., Chen, J., Higgins, G. A., Asberom, T., Li, W., Pissarnitski, D., Levitan, D., Nomeir, A. A., Clader, J. W., Zhang, L. and Parker, E. M. (2013). In Vivo Characterization of a Novel gamma-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects. Int J Alzheimers Dis 2013: 823528.
  8. Miller, D. J., Wiley, A. A., Chen, J. C., Bagnell, C. A. and Bartol, F. F. (2013). Nursing for 48 hours from birth supports porcine uterine gland development and endometrial cell compartment-specific gene expression. Biol Reprod 88(1): 4.
  9. Bartol, F. F., Wiley, A. A., Miller, D. J., Silva, A. J., Roberts, K. E., Davolt, M. L., Chen, J. C., Frankshun, A. L., Camp, M. E., Rahman, K. M., Vallet, J. L. and Bagnell, C. A. (2013). Lactation Biology Symposium: lactocrine signaling and developmental programming. J Anim Sci 91(2): 696-705.
  10. Frankshun, A. L., Chen, J., Barron, L. A., Ho, T. Y., Miller, D. J., Rahman, K. M., Bartol, F. F. and Bagnell, C. A. (2012). Nursing during the first two days of life is essential for the expression of proteins important for growth and remodeling of the neonatal porcine cervix. Endocrinology 153(9): 4511-4521.
  11. Ho, T. Y., Santora, K., Chen, J. C., Frankshun, A. L. and Bagnell, C. A. (2011). Effects of relaxin and estrogens on bone remodeling markers, receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG), in rat adjuvant-induced arthritis. Bone 48(6): 1346-1353.
  12. Chen, J. C., Frankshun, A. L., Wiley, A. A., Miller, D. J., Welch, K. A., Ho, T. Y., Bartol, F. F. and Bagnell, C. A. (2011). Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus. Reproduction 141(5): 675-683.
  13. Frankshun, A. L., Ho, T. Y., Reimer, D. C., Chen, J., Lasano, S., Steinetz, B. G., Bartol, F. F. and Bagnell, C. A. (2011). Characterization and biological activity of relaxin in porcine milk. Reproduction 141(3): 373-380.
  14. Chen, J. C., Wiley, A. A., Ho, T. Y., Frankshun, A. L., Hord, K. M., Bartol, F. F. and Bagnell, C. A. (2010). Transient estrogen exposure from birth affects uterine expression of developmental markers in neonatal gilts with lasting consequences in pregnant adults. Reproduction 139(3): 623-630.
  15. Chen, J. C., Wiley, A. A., Kauffold, J., Wahner, M., Bartol, F. F. and Bagnell, C. A. (2009). Perinatal zearalenone exposure affects RXFP1, RXFP2, and morphoregulatory gene expression in the neonatal porcine uterus. Ann N Y Acad Sci 1160: 188-189.
  16. Yan, W.*, Chen, J.*, Wiley, A. A., Crean-Harris, B. D., Bartol, F. F. and Bagnell, C. A. (2008). Relaxin (RLX) and estrogen affect estrogen receptor alpha, vascular endothelial growth factor, and RLX receptor expression in the neonatal porcine uterus and cervix. Reproduction 135(5): 705-712.( * authors contributed equally to the work)
  17. McLeod, R. L., Jia, Y., McHugh, N. A., Fernandez, X., Mingo, G. G., Wang, X., Parra, L. E., Chen, J., Brown, D., Bolser, D. C., Kreutner, W. and Hey, J. A. (2007). Sulfur-dioxide exposure increases TRPV1-mediated responses in nodose ganglia cells and augments cough in guinea pigs. Pulm Pharmacol Ther 20(6): 750-757.
  18. Hyde, L. A., McHugh, N. A., Chen, J., Zhang, Q., Manfra, D., Nomeir, A. A., Josien, H., Bara, T., Clader, J. W., Zhang, L., Parker, E. M. and Higgins, G. A. (2006). Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-di hydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse. J Pharmacol Exp Ther 319(3): 1133-1143.
Protocols by Joseph C. Chen
  1. Isolation and Culture of Human Endometrial Epithelial Cells and Stromal Fibroblasts