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Yan Xu


Ph.D. in Biochemistry, State University of New York at Albany, USA, 1988

Current position

The Hulman-George Family Professor of Gynecologic Cancer, Department of Obstetrics and Gynecology, Indiana University School of Medicine, USA

Publications (since 2005)

  1. Cai, Q. and Xu, Y. (2015). Microenvironment reprograms the circuits in tumor cells. Molecular & Cellular Oncology 2(1): e969634.
  2. Cai, Q., Yan, L. and Xu, Y. (2015). Anoikis resistance is a critical feature of highly aggressive ovarian cancer cells. Oncogene 34(25): 3315-3324.
  3. Yan, L., Cai, Q. and Xu, Y. (2014). Hypoxic conditions differentially regulate TAZ and YAP in cancer cells. Arch Biochem Biophys 562: 31-36.
  4. Cai, H., Chiorean, E. G., Chiorean, M. V., Rex, D. K., Robb, B. W., Hahn, N. M., Liu, Z., Loehrer, P. J., Harrison, M. L. and Xu, Y. (2013). Elevated phospholipase A2 activities in plasma samples from multiple cancers. PLoS One 8(2): e57081.
  5. Cai, H. and Xu, Y. (2013). The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells. Cell Commun Signal 11(1): 31.
  6. Li, J., Guo, B., Wang, J., Cheng, X., Xu, Y.* and Sang, J. (2013). Ovarian cancer G protein coupled receptor 1 suppresses cell migration of MCF7 breast cancer cells via a Galpha12/13-Rho-Rac1 pathway. J Mol Signal 8(1): 6. (*Co-corresponding author)
  7. Yan, L., Cai, Q. and Xu, Y. (2013). The ubiquitin-CXCR4 axis plays an important role in acute lung infection-enhanced lung tumor metastasis. Clin Cancer Res 19(17): 4706-4716.
  8. Li, S., Guo, B., Song, J., Deng, X., Cong, Y., Li, P., Zhao, K., Liu, L., Xiao, G. and Xu, F. (2013). Plasma choline-containing phospholipids: potential biomarkers for colorectal cancer progression. Metabolomics 9(1): 202-212.
  9. Yan, L., Singh, L. S., Zhang, L. and Xu, Y. (2014). Role of OGR1 in myeloid-derived cells in prostate cancer. Oncogene 33(2): 157-164.
  10. Skill, N. J., Jianmin, W., Yan, X., Zhao, Z., Tector, A. J. and Maluccio, M. A. (2013). Lysophospholipid variants in hepatocellular carcinoma. J Surg Res 182(2): 241-249. (Epub ahead of print)
  11. Cai, Q., Zhao, Z., Antalis, C., Yan, L., Del Priore, G., Hamed, A. H., Stehman, F. B., Schilder, J. M. and Xu, Y. (2012). Elevated and secreted phospholipase A(2) activities as new potential therapeutic targets in human epithelial ovarian cancer. FASEB J 26(8): 3306-3320. (Epub ahead of print)
  12. Zhao, Z., Yu, M., Crabb, D., Xu, Y. and Liangpunsakul, S. (2011). Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice. Alcohol Clin Exp Res 35(2): 229-234.
  13. Li, H., Zhang, H., Wei, G., Cai, Q., Yan, L. and Xu, Y. (2011). Tumor cell group via phospholipase A(2) is involved in prostate cancer development. Prostate 71(4): 373-384.
  14. Li, H., Zhao, Z., Antalis, C., Zhao, Z., Emerson, R., Wei, G., Zhang, S., Zhang, Z. Y. and Xu, Y. (2011). Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development. Am J Pathol 179(1): 452-461.
  15. Zhao, Z. and Xu, Y. (2010). An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples. J Lipid Res 51(3): 652-659.
  16. Li, H., Zhao, Z., Wei, G., Yan, L., Wang, D., Zhang, H., Sandusky, G. E., Turk, J. and Xu, Y. (2010). Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development. FASEB J 24(10): 4103-4116.
  17. Li, H., Wang, D., Zhang, H., Kirmani, K., Zhao, Z., Steinmetz, R. and Xu, Y. (2009). Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice. Mol Cancer Ther 8(6): 1692-1701.
  18. Li, H., Wang, D., Singh, L. S., Berk, M., Tan, H., Zhao, Z., Steinmetz, R., Kirmani, K., Wei, G. and Xu, Y. (2009). Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One 4(5): e5705.
  19. Zhao, Z. and Xu, Y. (2009). Measurement of endogenous lysophosphatidic acid by ESI-MS/MS in plasma samples requires pre-separation of lysophosphatidylcholine. J Chromatogr B Analyt Technol Biomed Life Sci 877(29): 3739-3742.
  20. Tager, A. M., LaCamera, P., Shea, B. S., Campanella, G. S., Selman, M., Zhao, Z., Polosukhin, V., Wain, J., Karimi-Shah, B. A., Kim, N. D., Hart, W. K., Pardo, A., Blackwell, T. S., Xu, Y., Chun, J. and Luster, A. D. (2008). The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med 14(1): 45-54.
  21. Wang, D., Zhao, Z., Caperell-Grant, A., Yang, G., Mok, S. C., Liu, J., Bigsby, R. M. and Xu, Y. (2008). S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells. Mol Cancer Ther 7(7): 1993-2002.
  22. Sengupta, S., Kim, K. S., Berk, M. P., Oates, R., Escobar, P., Belinson, J., Li, W., Lindner, D. J., Williams, B. and Xu, Y. (2007). Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion. Oncogene 26(20): 2894-2901.
  23. Singh, A. D., Sisley, K., Xu, Y., Li, J., Faber, P., Plummer, S. J., Mudhar, H. S., Rennie, I. G., Kessler, P. M., Casey, G. and Williams, B. G. (2007). Reduced expression of autotaxin predicts survival in uveal melanoma. Br J Ophthalmol 91(10): 1385-1392.
  24. Zhao, Z., Xiao, Y., Elson, P., Tan, H., Plummer, S. J., Berk, M., Aung, P. P., Lavery, I. C., Achkar, J. P., Li, L., Casey, G. and Xu, Y. (2007). Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer. J Clin Oncol 25(19): 2696-2701.
  25. Singh, L. S., Berk, M., Oates, R., Zhao, Z., Tan, H., Jiang, Y., Zhou, A., Kirmani, K., Steinmetz, R., Lindner, D. and Xu, Y. (2007). Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer. J Natl Cancer Inst 99(17): 1313-1327.
  26. Zhang, Z., Lee, Y. C., Kim, S. J., Choi, M. S., Tsai, P. C., Xu, Y., Xiao, Y. J., Zhang, P., Heffer, A. and Mukherjee, A. B. (2006). Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL. Hum Mol Genet 15(2): 337-346.
  27. Ren, J., Xiao, Y. J., Singh, L. S., Zhao, X., Zhao, Z., Feng, L., Rose, T. M., Prestwich, G. D. and Xu, Y. (2006). Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells. Cancer Res 66(6): 3006-3014.
  28. Kim, K. S., Sengupta, S., Berk, M., Kwak, Y. G., Escobar, P. F., Belinson, J., Mok, S. C. and Xu, Y. (2006). Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo. Cancer Res 66(16): 7983-7990.
  29. Zhao, X., Wang, D., Zhao, Z., Xiao, Y., Sengupta, S., Xiao, Y., Zhang, R., Lauber, K., Wesselborg, S., Feng, L., Rose, T. M., Shen, Y., Zhang, J., Prestwich, G. and Xu, Y. (2006). Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells. J Biol Chem 281(39): 29357-29368.
  30. Zaslavsky, A., Singh, L. S., Tan, H., Ding, H., Liang, Z. and Xu, Y. (2006). Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4. Biochim Biophys Acta 1761(10): 1200-1212.
  31. Kim, K. S., Ren, J., Jiang, Y., Ebrahem, Q., Tipps, R., Cristina, K., Xiao, Y. J., Qiao, J., Taylor, K. L., Lum, H., Anand-Apte, B. and Xu, Y. (2005). GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. FASEB J 19(7): 819-821.
  32. Zaslavsky, A., Li, S. and Xu, Y. (2005). Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells. FEBS Lett 579(18): 3899-3906.
  33. Jiang, Y., Berk, M., Singh, L. S., Tan, H., Yin, L., Powell, C. T. and Xu, Y. (2005). KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha. Clin Exp Metastasis 22(5): 369-376.
Protocols by Yan Xu
  1. Adoptive Transfer of Myeloid-Derived Suppressor Cells and T Cells in a Prostate Cancer Model