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Hexin Chen


Ph.D. in Molecular Virology, University of Nebraska-Lincoln, 2000, USA

Current position

Assistant Professor, Department of Biological Sciences, University of South Carolina, USA


  1. Kanojia, D., Zhou, W., Zhang, J., Jie, C., Lo, P. K., Wang, Q. and Chen, H. (2012). Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice. Proteomics 12(22): 3407-3415.
  2. Lo, P. K., Kanojia, D., Liu, X., Singh, U. P., Berger, F. G., Wang, Q. and Chen, H. (2012). CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFbeta signaling. Oncogene 31(21): 2614-2626.
  3. Jo, H., Lo, P. K., Li, Y., Loison, F., Green, S., Wang, J., Silberstein, L. E., Ye, K., Chen, H.* and Luo, H. R.* (2011). Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A 108(16): 6486-6491. (*corresponding author and highlighted in Nature Chem. Biol. 2011, 7:340).
  4. Chen, H.*, Pimienta, G., Gu, Y., Sun, X., Hu, J., Kim, M. S., Chaerkady, R., Gucek, M., Cole, R. N., Sukumar, S. and Pandey, A.* (2010). Proteomic characterization of Her2/neu-overexpressing breast cancer cells. Proteomics 10(21): 3800-3810. (*corresponding author).
  5. Chen, H., Lee, J. S., Liang, X., Zhang, H., Zhu, T., Zhang, Z., Taylor, M. E., Zahnow, C., Feigenbaum, L., Rein, A. and Sukumar, S. (2008). Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis. Cancer Res 68(10): 3637-3644.
  6. Chen, H., Zhang, H., Lee, J., Liang, X., Wu, X., Zhu, T., Lo, P. K., Zhang, X. and Sukumar, S. (2007). HOXA5 acts directly downstream of retinoic acid receptor beta and contributes to retinoic acid-induced apoptosis and growth inhibition. Cancer Res 67(17): 8007-8013.
  7. Chen, H., Rubin, E., Zhang, H., Chung, S., Jie, C. C., Garrett, E., Biswal, S. and Sukumar, S. (2005). Identification of transcriptional targets of HOXA5. J Biol Chem 280(19): 19373-19380.
  8. Chen, H., Chung, S. and Sukumar, S. (2004). HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8. Mol Cell Biol 24(2): 924-935.
  9. Chen, H. and Sukumar, S. (2003). Role of homeobox genes in normal mammary gland development and breast tumorigenesis. J Mammary Gland Biol Neoplasia 8(2): 159-175.
  10. Chen, H. and Sukumar, S. (2003). HOX genes: emerging stars in cancer. Cancer Biol Ther 2(5): 524-525.
  11. Chen, H., Wood, C. and Petito, C. K. (2000). Comparisons of HIV-1 viral sequences in brain, choroid plexus and spleen: potential role of choroid plexus in the pathogenesis of HIV encephalitis. J Neurovirol 6(6): 498-506.
  12. Chen, H., He, J., Fong, S., Wilcox, G. and Wood, C. (2000). Jembrana disease virus Tat can regulate human immunodeficiency virus (HIV) long terminal repeat-directed gene expression and can substitute for HIV Tat in viral replication. J Virol 74(6): 2703-2713.
  13. Chen, H., Wilcox, G., Kertayadnya, G. and Wood, C. (1999). Characterization of the Jembrana disease virus tat gene and the cis- and trans-regulatory elements in its long terminal repeats. J Virol 73(1): 658-666
Protocols by Hexin Chen
  1. In vitro Tumorsphere Formation Assays
  2. Isolation of Cancer Epithelial Cells from Mouse Mammary Tumors
  3. Isolation of Primary Breast Cancer Cells from HER2 Transgenic Mice