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Sara Gianella

Education

M.D., University of Zurich, Zurich, Switzerland, 2003

Current position

Assistant Professor of Medicine in Department of Medicine, University of California San Diego, USA (04/2013-present)

Publications

  1. Dillon, S. M., Lee, E. J., Kotter, C. V., Austin, G. L., Dong, Z., Hecht, D. K., Gianella, S., Siewe, B., Smith, D. M., Landay, A. L., Robertson, C. E., Frank, D. N. and Wilson, C. C. (2014). An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia. Mucosal Immunol 7(4): 983-994.
  2. Gianella, S., Massanella, M., Richman, D. D., Little, S. J., Spina, C. A., Vargas, M. V., Lada, S. M., Daar, E. S., Dube, M. P., Haubrich, R. H., Morris, S. R., Smith, D. M. and California Collaborative Treatment Group, T. (2014). Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment. J Virol 88(14): 7818-7827.
  3. Chaillon, A., Gianella, S., Wertheim, J. O., Richman, D. D., Mehta, S. R. and Smith, D. M. (2014). HIV migration between blood and cerebrospinal fluid or semen over time. J Infect Dis 209(10): 1642-1652.
  4. Chaillon, A., Samleerat, T., Zoveda, F., Ballesteros, S., Moreau, A., Ngo-Giang-Huong, N., Jourdain, G., Gianella, S., Lallemant, M., Depaulis, F. and Barin, F. (2014). Estimating the timing of mother-to-child transmission of the human immunodeficiency virus type 1 using a viral molecular evolution model. PLoS One 9(4): e90421.
  5. Chaillon, A., Gianella, S., Vazquez, H., Ignacio, C., Zweig, A. C., Richman, D. D. and Smith, D. M. (2014). Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy. AIDS Res Hum Retroviruses 30(2): 165-169.
  6. Chaillon, A., Gianella, S., Massanella Luna, M., Little, S. J., Richman, D. D. and Mehta, S. R. (2014). A case cluster demonstrating the relationship between HLA concordance and virologic and disease outcomes in human immunodeficiency virus infection. Virology 449: 104-108.
  7. Tatro, E. T., Purnajo, I., Richman, D. D., Smith, D. M. and Gianella, S. (2014). Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation. Clin Vaccine Immunol 21(1): 46-50.
  8. Gianella, S., Morris, S. R., Tatro, E., Vargas, M. V., Haubrich, R. H., Daar, E. S., Dube, M. P., Richman, D. D., Little, S. J. and Smith, D. M. (2014). Virologic correlates of anti-CMV IgG levels in HIV-1-infected men. J Infect Dis 209(3): 452-456.
  9. Perez-Santiago, J., Gianella, S., Massanella, M., Spina, C. A., Karris, M. Y., Var, S. R., Patel, D., Jordan, P. S., Young, J. A., Little, S. J., Richman, D. D. and Smith, D. M. (2013). Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS 27(12): 1921-1931.
  10. Strain, M. C., Lada, S. M., Luong, T., Rought, S. E., Gianella, S., Terry, V. H., Spina, C. A., Woelk, C. H. and Richman, D. D. (2013). Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One 8(4): e55943.
  11. Wagner, G. A., Pacold, M. E., Vigil, E., Caballero, G., Morris, S. R., Kosakovsky Pond, S. L., Little, S. J., Richman, D. D., Gianella, S.** and Smith, D. M.** (2013). Using ultradeep pyrosequencing to study HIV-1 coreceptor usage in primary and dual infection. J Infect Dis 208(2): 271-274.
  12. Gianella, S., Anderson, C. M., Vargas, M. V., Richman, D. D., Little, S. J., Morris, S. R. and Smith, D. M. (2013). Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA. J Infect Dis 207(6): 898-902.
  13. Gianella, S., Smith, D. M., Vargas, M. V., Little, S. J., Richman, D. D., Daar, E. S., Dube, M. P., Zhang, F., Ginocchio, C. C., Haubrich, R. H., Morris, S. R. and Team, C. (2013). Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men. Clin Infect Dis 57(3): 441-447.
  14. Sassi, M., Mueller, N. J., Yazaki, H., Oka, S., Gianella, S. and Kovacs, J. A. (2013). Reply to Hauser et Al. Clin Infect Dis 56(1): 166-167.
  15. Gianella, S., Smith, D. M., Vargas, M. V., Little, S. J., Richman, D. D., Daar, E. S., Dube, M. P., Zhang, F., Ginocchio, C. C., Haubrich, R. H., Morris, S. R. and Team, C. (2013). Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men. Clin Infect Dis 57(3): 441-447.
  16. Gianella, S., Haubrich, H. R. and Morris, S. R. (2013). Suppressed but still Infectious. Future Virology 8(11): 1037–1040.
  17. Gianella, S., Mehta, S. R., Young, J. A., Vargas, M. V., Little, S. J., Richman, D. D., Kosakovsky Pond, S. L. and Smith, D. M. (2012). Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells. Virology 434(1): 2-4.
  18. Gianella, S., Mehta, S. R., Strain, M. C., Young, J. A., Vargas, M. V., Little, S. J., Richman, D. D., Kosakovsky Pond, S. L. and Smith, D. M. (2012). Impact of seminal cytomegalovirus replication on HIV-1 dynamics between blood and semen. J Med Virol 84(11): 1703-1709.
  19. Gianella, S., Morris, S. R., Vargas, M. V., Young, J. A., Callahan, B., Richman, D. D., Little, S. J. and Smith, D. M. (2013). Role of seminal shedding of herpesviruses in HIV Type 1 Transmission. J Infect Dis 207(2): 257-261.
  20. Sassi, M., Ripamonti, C., Mueller, N. J., Yazaki, H., Kutty, G., Ma, L., Huber, C., Gogineni, E., Oka, S., Goto, N., Fehr, T., Gianella, S., Konrad, R., Sing, A. and Kovacs, J. A. (2012). Outbreaks of Pneumocystis pneumonia in 2 renal transplant centers linked to a single strain of Pneumocystis: implications for transmission and virulence. Clin Infect Dis 54(10): 1437-1444.
  21. Gianella, S., Strain, M. C., Rought, S. E., Vargas, M. V., Little, S. J., Richman, D. D., Spina, C. A. and Smith, D. M. (2012). Associations between virologic and immunologic dynamics in blood and in the male genital tract. J Virol 86(3): 1307-1315.
  22. Wyl, V., Gianella, S., Fischer, M., Niederoest, B., Kuster, H., Battegay, M., Bernasconi, E., Cavassini, M., Rauch, A., Hirschel, B., Vernazza, P., Weber, R., Joos, B., Gunthard, H. F. and Swiss, H. I. V. C. S.-S. (2011). Early antiretroviral therapy during primary HIV-1 infection results in a transient reduction of the viral setpoint upon treatment interruption. PLoS One 6(11): e27463.
  23. Rieder, P., Joos, B., Scherrer, A. U., Kuster, H., Braun, D., Grube, C., Niederost, B., Leemann, C., Gianella, S., Metzner, K. J., Boni, J., Weber, R. and Gunthard, H. F. (2011). Characterization of human immunodeficiency virus type 1 (HIV-1) diversity and tropism in 145 patients with primary HIV-1 infection. Clin Infect Dis 53(12): 1271-1279.
  24. Gianella, S., Delport, W., Pacold, M. E., Young, J. A., Choi, J. Y., Little, S. J., Richman, D. D., Kosakovsky Pond, S. L. and Smith, D. M. (2011). Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants. J Virol 85(16): 8359-8367.
  25. Gianella, S., Delport, W., Pacold, M. E., Young, J. A., Choi, J. Y., Little, S. J., Richman, D. D., Kosakovsky Pond, S. L. and Smith, D. M. (2011). Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants. J Virol 85(16): 8359-8367.
  26. Yukl, S. A., Shergill, A. K., McQuaid, K., Gianella, S., Lampiris, H., Hare, C. B., Pandori, M., Sinclair, E., Gunthard, H. F., Fischer, M., Wong, J. K. and Havlir, D. V. (2010). Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS 24(16): 2451-2460.
  27. Yukl, S. A., Gianella, S., Sinclair, E., Epling, L., Li, Q., Duan, L., Choi, A. L., Girling, V., Ho, T., Li, P., Fujimoto, K., Lampiris, H., Hare, C. B., Pandori, M., Haase, A. T., Gunthard, H. F., Fischer, M., Shergill, A. K., McQuaid, K., Havlir, D. V. and Wong, J. K. (2010). Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy. J Infect Dis 202(10): 1553-1561.
  28. Althaus, C. F., Gianella, S., Rieder, P., von Wyl, V., Kouyos, R. D., Niederost, B., Schmid, A., Metzner, K. J., Joos, B., Gunthard, H. F. and Fischer, M. (2010). Rational design of HIV-1 fluorescent hydrolysis probes considering phylogenetic variation and probe performance. J Virol Methods 165(2): 151-160.
  29. Gianella, S., Haeberli, L., Joos, B., Ledergerber, B., Wuthrich, R. P., Weber, R., Kuster, H., Hauser, P. M., Fehr, T. and Mueller, N. J. (2010). Molecular evidence of interhuman transmission in an outbreak of Pneumocystis jirovecii pneumonia among renal transplant recipients. Transpl Infect Dis 12(1): 1-10.
  30. Gianella, S. and Richman, D. D. (2010). Minority variants of drug-resistant HIV. J Infect Dis 202(5): 657-666.
  31. Schmid, A., Gianella, S., von Wyl, V., Metzner, K. J., Scherrer, A. U., Niederost, B., Althaus, C. F., Rieder, P., Grube, C., Joos, B., Weber, R., Fischer, M. and Gunthard, H. F. (2010). Profound depletion of HIV-1 transcription in patients initiating antiretroviral therapy during acute infection. PLoS One 5(10): e13310.
  32. Yukl, S. A., Shergill, A. K., McQuaid, K., Gianella, S., Lampiris, H., Hare, C. B., Pandori, M., Sinclair, E., Gunthard, H. F., Fischer, M., Wong, J. K. and Havlir, D. V. (2010). Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS 24(16): 2451-2460.
  33. Yukl, S. A., Gianella, S., Sinclair, E., Epling, L., Li, Q., Duan, L., Choi, A. L., Girling, V., Ho, T., Li, P., Fujimoto, K., Lampiris, H., Hare, C. B., Pandori, M., Haase, A. T., Gunthard, H. F., Fischer, M., Shergill, A. K., McQuaid, K., Havlir, D. V. and Wong, J. K. (2010). Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy. J Infect Dis 202(10): 1553-1561.
  34. Gianella, S., Haeberli, L., Joos, B., Ledergerber, B., Wuthrich, R. P., Weber, R., Kuster, H., Hauser, P. M., Fehr, T. and Mueller, N. J. (2010). Molecular evidence of interhuman transmission in an outbreak of Pneumocystis jirovecii pneumonia among renal transplant recipients. Transpl Infect Dis 12(1): 1-10.
  35. Schmid, A., Gianella, S., von Wyl, V., Metzner, K. J., Scherrer, A. U., Niederost, B., Althaus, C. F., Rieder, P., Grube, C., Joos, B., Weber, R., Fischer, M. and Gunthard, H. F. (2010). Profound depletion of HIV-1 transcription in patients initiating antiretroviral therapy during acute infection. PLoS One 5(10): e13310.
  36. Gianella, S., Schaer, D . J., Schwarz, U., Kurrer, M., Heppner, F. L., Fehr, J. and Seebach, J. D. (2008). Retinal microangiopathy and rapidly fatal cerebral edema in a patient with adult-onset Still's disease and concurrent macrophage activation syndrome. Am J Hematol 83(5): 424-427.
  37. Gianella, S., Ulrich, S., Huttner, B. and Speich, R. (2006). Conservative management of a brain abscess in a patient with Staphylococcus lugdunensis endocarditis. Eur J Clin Microbiol Infect Dis 25(7): 476-478.
  38. Wyttenbach, R., Gianella, S., Alerci, M., Braghetti, A., Cozzi, L. and Gallino, A. (2003). Prospective blinded evaluation of Gd-DOTA- versus Gd-BOPTA-enhanced peripheral MR angiography, as compared with digital subtraction angiography. Radiology 227(1): 261-269.
  39. Althaus, C. F., Gianella, S., Rieder, P., von Wyl, V., Kouyos, R. D., Niederost, B., Schmid, A., Metzner, K. J., Joos, B., Gunthard, H. F. and Fischer, M. (2010). Rational design of HIV-1 fluorescent hydrolysis probes considering phylogenetic variation and probe performance. J Virol Methods 165(2): 151-160.

    *= Shared first author
    **= Shared last author
Protocols by Sara Gianella
  1. Quantification of HIV RNA and Human Herpesvirus DNA in Seminal Plasma
  2. Quantification of Total and 2-LTR (Long terminal repeat) HIV DNA, HIV RNA and Herpesvirus DNA in PBMCs