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François Xavier Campbell-Valois

Education

Ph.D. in Molecular Biology, University of Montreal, Montréal, Canada, 2006

Current position

Assistant Professor, University of Ottawa, Ottawa, Canada (08/2015-present)

Publications

Peer reviewed publications

  1. Campbell-Valois, F. X.* and Pontier, S. M. (2016). Implications of Spatiotemporal Regulation of Shigella flexneri Type Three Secretion Activity on Effector Functions: Think Globally, Act Locally. Front Cell Infect Microbiol 6: 28. (*Corresponding author)
  2. Arena, E. T., Campbell-Valois, F. X., Tinevez, J. Y., Nigro, G., Sachse, M., Moya-Nilges, M., Nothelfer, K., Marteyn, B., Shorte, S. L. and Sansonetti, P. J. (2015). Bioimage analysis of Shigella infection reveals targeting of colonic crypts. Proc Natl Acad Sci U S A 112(25): E3282-3290. (Equal contributions)
  3. Campbell-Valois, F. X.*, Sachse, M., Sansonetti, P. J. and Parsot, C. (2015). Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA. MBio 6(3): e02567-02514. (*Corresponding author)
  4. Campbell-Valois, F. X.*, Schnupf, P., Sansonetti P. J. (2014). Design of a Transcription-based Secretion Activity Reporter (TSAR) for the Type III secretion apparatus of S. flexneri and uses thereof. Bio-protocol 4(20): e1270. (*Corresponding author)
  5. Campbell-Valois, F. X.*, Schnupf, P. and Sansonetti, P. J. (2014). Detection of the Secreted and Cytoplasmic Fractions of IpaB, IpaC and IpaD by Lysozyme Permeabilization. Bio-protocol 4(20): e1271. (*Corresponding author)
  6. Campbell-Valois, F.X. and Sansonetti, P.J. (2014). Tracking Bacterial Pathogen infection with geneticallyencoded reporters, FEBS Letters 2014 Aug 1;588(15):2428-36.
  7. Grishin, A. M., Condos, T. E., Barber, K. R., Campbell-Valois, F. X., Parsot, C., Shaw, G. S. and Cygler, M. (2014). Structural basis for the inhibition of host protein ubiquitination by Shigella effector kinase OspG. Structure 22(6): 878-888.
  8. Campbell-Valois, F. X.*, Schnupf, P., Nigro, G., Sachse, M., Sansonetti, P. J. and Parsot, C. (2014). A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread. Cell Host Microbe 15(2): 177-189. (*Corresponding author)
  9. Campbell-Valois, F. X.* , Trost, M.* , Chemali, M., Dill, B. D., Laplante, A., Duclos, S., Sadeghi, S., Rondeau, C., Morrow, I. C., Bell, C., Gagnon, E., Hatsuzawa, K., Thibault, P. and Desjardins, M. (2012). Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Mol Cell Proteomics 11(7): M111 016378. (*Corresponding authors; Equal contribution)
  10. Remy, I., Campbell-Valois, F. X. and Michnick, S. W. (2007). Detection of protein-protein interactions using a simple survival protein-fragment complementation assay based on the enzyme dihydrofolate reductase. Nat Protoc 2(9): 2120-2125.
  11. Campbell-Valois, F. X. and Michnick, S. W. (2007). The transition state of the ras binding domain of Raf is structurally polarized based on φ-values but is energetically diffuse. J Mol Biol 365(5): 1559-1577.
  12. Campbell-Valois, F. X. and Michnick, S. W. (2007). Synthesis of degenerated libraries of the ras-binding domain of raf and rapid selection of fast-folding and stable clones with the dihydrofolate reductase protein fragment complementation assay. Methods Mol Biol 352: 249-274.
  13. Campbell-Valois, F. X., Tarassov, K. and Michnick, S. W. (2006). Massive sequence perturbation of the Raf ras binding domain reveals relationships between sequence conservation, secondary structure propensity, hydrophobic core organization and stability. J Mol Biol 362(1): 151-171.
  14. Campbell-Valois, F. X., Tarassov, K. and Michnick, S. W. (2005). Massive sequence perturbation of a small protein. Proc Natl Acad Sci U S A 102(42): 14988-14993.
  15. Campbell-Valois, F. X. and Michnick, S. (2005). Chemical biology on PINs and NeeDLes. Curr Opin Chem Biol 9(1): 31-37.
  16. Michnick, S. W. and Valois, F. X. (2002). Gene function: getting specific, generally speaking. Proc Natl Acad Sci U S A 99(26): 16513-16515.
  17. Michnick, S. W., Remy, I., Campbell-Valois, F. X., Vallee-Belisle, A. and Pelletier, J. N. (2000). Detection of protein-protein interactions by protein fragment complementation strategies. Methods Enzymol 328: 208-230.
  18. Pelletier, J. N., Campbell-Valois, F. X. and Michnick, S. W. (1998). Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments. Proc Natl Acad Sci U S A 95(21): 12141-12146.

Books or book chapters

  1. Campbell-Valois, F. X. (2014). Folding of the polypeptide sequence of small proteins (French). Presses Académiques Francophones.
  2. Remy, I., Campbell-Valois, F. X., Aquin, S., Ghaddar, G. and Michnick, S. W. (2005). Detection of protein interactions and library screening with protein fragment complementation strategies. Molecular Biology Protocols Protein-protein interactions, second edition, Chapitre 33, pp. 637-671.
Protocols by François Xavier Campbell-Valois
  1. Design of a Transcription-based Secretion Activity Reporter (TSAR) for the Type III Secretion Apparatus of Shigella flexneri and Uses Thereof
  2. Detection of the Secreted and Cytoplasmic Fractions of IpaB, IpaC and IpaD by Lysozyme Permeabilization