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Jan-Henning Klusmann

Education

Dr. Med. in Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany

Current position

Resident, Pediatric Hematology and Oncology, Hannover Medical School, Hannover (2014-present)
Emmy Noether Junior Research Group leader of “Pediatric Hematology and Oncology”, Hannover Medical School (2011-present)

Publications

  1. Stankov, M. V., El Khatib, M., Kumar Thakur, B., Heitmann, K., Panayotova-Dimitrova, D., Schoening, J., Bourquin, J. P., Schweitzer, N., Leverkus, M., Welte, K., Reinhardt, D., Li, Z., Orkin, S. H., Behrens, G. M. and Klusmann, J. H. (2014). Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy. Leukemia 28(3): 577-588.
  2. Maroz, A., Stachorski, L., Emmrich, S., Reinhardt, K., Xu, J., Shao, Z., Kabler, S., Dertmann, T., Hitzler, J., Roberts, I., Vyas, P., Juban, G., Hennig, C., Hansen, G., Li, Z., Orkin, S., Reinhardt, D. and Klusmann, J. H. (2013). GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia. Leukemia. [Epub ahead of print]
  3. Emmrich, S.*, Katsman-Kuipers, J. E.*, Henke, K., Khatib, M. E., Jammal, R., Engeland, F., Dasci, F., Zwaan, C. M., den Boer, M. L., Verboon, L., Stary, J., Baruchel, A., de Haas, V., Danen-van Oorschot, A. A., Fornerod, M., Pieters, R., Reinhardt, D., Klusmann, J. H.* and van den Heuvel-Eibrink, M. M.* (2013). miR-9 is a tumor suppressor in pediatric AML with t(8;21). Leukemia. [Epub ahead of print] *Contributed equally
  4. Gross, B., Sgodda, M., Rasche, M., Schambach, A., Gohring, G., Schlegelberger, B., Greber, B., Linden, T., Reinhardt, D., Cantz, T. and Klusmann, J. H. (2013). Improved generation of patient-specific induced pluripotent stem cells using a chemically-defined and matrigel-based approach. Curr Mol Med 13(5): 765-776.
  5. Emmrich, S., Henke, K., Hegermann, J., Ochs, M., Reinhardt, D. and Klusmann, J. H. (2012). miRNAs can increase the efficiency of ex vivo platelet generation. Ann Hematol 91(11): 1673-1684.
  6. Klusmann, J. H., Reinhardt, D., Zimmermann, M., Kremens, B., Vormoor, J., Dworzak, M., Creutzig, U. and Klingebiel, T. (2012). The role of matched sibling donor allogeneic stem cell transplantation in pediatric high-risk acute myeloid leukemia: results from the AML-BFM 98 study. Haematologica 97(1): 21-29.
  7. Klusmann, J. H., Godinho, F. J., Heitmann, K., Maroz, A., Koch, M. L., Reinhardt, D., Orkin, S. H. and Li, Z. (2010). Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev 24(15): 1659-1672.
  8. Klusmann, J. H., Li, Z., Bohmer, K., Maroz, A., Koch, M. L., Emmrich, S., Godinho, F. J., Orkin, S. H. and Reinhardt, D. (2010). miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev 24(5): 478-490.
  9. Klusmann, J. H., Creutzig, U., Zimmermann, M., Dworzak, M., Jorch, N., Langebrake, C., Pekrun, A., Macakova-Reinhardt, K. and Reinhardt, D. (2008). Treatment and prognostic impact of transient leukemia in neonates with Down syndrome. Blood 111(6): 2991-2998.
  10. Klusmann, J. H., Reinhardt, D., Hasle, H., Kaspers, G. J., Creutzig, U., Hahlen, K., van den Heuvel-Eibrink, M. M. and Zwaan, C. M. (2007). Janus kinase mutations in the development of acute megakaryoblastic leukemia in children with and without Down's syndrome. Leukemia 21(7): 1584-1587.
  11. Li, Z., Godinho, F. J., Klusmann, J. H., Garriga-Canut, M., Yu, C. and Orkin, S. H. (2005). Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet 37(6): 613-619.
Protocols by Jan-Henning Klusmann
  1. Flow Cytometric Analysis of Autophagic Activity with Cyto-ID Staining in Primary Cells