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Begoña Díaz


Ph.D. in Biological Sciences, Madrid Autonoma University, Spain, 1999

Current position

Investigator, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, USA

Publications (since 2007)

  1. Burger, K. L., Learman, B. S., Boucherle, A. K., Sirintrapun, S. J., Isom, S., Diaz, B., Courtneidge, S. A. and Seals, D. F. (2013). Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells. Prostate.
  2. Diaz, B.*, Yuen, A., Iizuka, S., Higashiyama, S. and Courtneidge, S. A. (2013). Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. J Cell Biol 201(2): 279-292. *Author for correspondence
  3. Munson, J. M., Fried, L., Rowson, S. A., Bonner, M. Y., Karumbaiah, L., Diaz, B., Courtneidge, S. A., Knaus, U. G., Brat, D. J., Arbiser, J. L. and Bellamkonda, R. V. (2012). Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. Sci Transl Med 4(127): 127ra136.
  4. Diaz, B. and Courtneidge, S. A. (2012). Redox signaling at invasive microdomains in cancer cells. Free Radic Biol Med 52(2): 247-256.
  5. Murphy, D. A., Diaz, B.*, Bromann, P. A.*, Tsai, J. H., Kawakami, Y., Maurer, J., Stewart, R. A., Izpisua-Belmonte, J. C. and Courtneidge, S. A. (2011). A Src-Tks5 pathway is required for neural crest cell migration during embryonic development. PLoS One 6(7): e22499. *Equal contribution
  6. Diaz, B.*, Shani, G.*, Pass, I., Anderson, D., Quintavalle, M. and Courtneidge, S. A. (2009). Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal 2(88): ra53. *Equal contribution.
  7. Gianni, D., Diaz, B., Taulet, N., Fowler, B., Courtneidge, S. A. and Bokoch, G. M. (2009). Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal 2(88): ra54.
  8. Rhiner, C.*, Diaz, B.*, Portela, M., Poyatos, J. F., Fernandez-Ruiz, I., Lopez-Gay, J. M., Gerlitz, O. and Moreno, E. (2009). Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche. Development 136(6): 995-1006. *Equal contribution.
  9. Blouw, B., Seals, D. F., Pass, I., Diaz, B. and Courtneidge, S. A. (2008). A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo. Eur J Cell Biol 87(8-9): 555-567.
  10. Shvartsman, D. E., Donaldson, J. C., Diaz, B., Gutman, O., Martin, G. S. and Henis, Y. I. (2007). Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets. J Cell Biol 178(4): 675-686.

Protocols by Begoña Díaz
  1. Invadopodia Detection and Gelatin Degradation Assay