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Hong Lok Lung

Education

Ph.D. in Biochemistry, the Chinese University of Hong Kong, 1999

Current position

Assistant Professor, Clinical Oncology, the University of Hong Kong

My major research interests and projects: My current projects are mainly focused on the cancer genetics and the associated tumor microenvironment of nasopharyngeal carcinoma (NPC). We have previously identified some NPC tumor suppressor genes (TSGs) by using the functional complementation approach and the subsequent gene profiling and genotyping analyses. We are characterizing their tumor suppressive function and association with angiogenesis in NPC. Polymorphism analysis of some of our TSGs and their associations with NPC risk are my other major research interest. In addition, I am also interested to investigate whether the aggressive/metastatic phenotype of NPC cell lines is associated with tumor hypoxia

Publications (selected)

  1. Lung, H. L.,andLung, M. L. (2012). In vivo Matrigel Plug Angiogenesis Assay. Bio-Protocol 2(18).
  2. Lung, H. L., Cheung, A. K. L., Ko, J. M. Y., Cheng, Y. and Lung, M. L. (2012). Identification of tumor suppressor genes via cell fusion and chromosomal transfer. Tumor Suppressor Genes. InTech: Croatia: 53-78.
  3. Lung, H. L., Cheung, A. K., Ko, J. M., Cheng, Y., Stanbridge, E. J. and Lung, M. L. (2012). Deciphering the molecular genetic basis of NPC through functional approaches. Semin Cancer Biol 22(2): 87-95.
  4. Huang, Z., Cheng, Y., Chiu, P. M., Cheung, F. M., Nicholls, J. M., Kwong, D. L., Lee, A. W., Zabarovsky, E. R., Stanbridge, E. J., Lung, H. L.* and Lung, M. L.* (2012). Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties. Oncogene 31(32): 3709-3720. (*co-corresponding authorship)
  5. Cheung, A. K., Ko, J. M., Lung, H. L., Chan, K. W., Stanbridge, E. J., Zabarovsky, E., Tokino, T., Kashima, L., Suzuki, T., Kwong, D. L., Chua, D., Tsao, S. W. and Lung, M. L. (2011). Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis. Proc Natl Acad Sci U S A 108(20): 8390-8395.
  6. Lo, P. H.*, Lung, H. L.*, Cheung, A. K., Apte, S. S., Chan, K. W., Kwong, F. M., Ko, J. M., Cheng, Y., Law, S., Srivastava, G., Zabarovsky, E. R., Tsao, S. W., Tang, J. C., Stanbridge, E. J. and Lung, M. L. (2010). Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. Cancer Res 70(13): 5567-5576. (*co-first authorship)
  7. Lung, H. L., Cheung, A. K., Cheng, Y., Kwong, F. M., Lo, P. H., Law, E. W., Chua, D., Zabarovsky, E. R., Wang, N., Tsao, S. W., Stanbridge, E. J. and Lung, M. L. (2010). Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma. Int J Cancer 127(2): 304-312.
  8. Cheung, A. K., Lung, H. L., Ko, J. M., Cheng, Y., Stanbridge, E. J., Zabarovsky, E. R., Nicholls, J. M., Chua, D., Tsao, S. W., Guan, X. Y. and Lung, M. L. (2009). Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma. Proc Natl Acad Sci U S A 106(34): 14478-14483.
  9. Cheung, A. K., Lung, H. L., Hung, S. C., Law, E. W., Cheng, Y., Yau, W. L., Bangarusamy, D. K., Miller, L. D., Liu, E. T., Shao, J. Y., Kou, C. W., Chua, D., Zabarovsky, E. R., Tsao, S. W., Stanbridge, E. J. and Lung, M. L. (2008). Functional analysis of a cell cycle-associated, tumor-suppressive gene, protein tyrosine phosphatase receptor type G, in nasopharyngeal carcinoma. Cancer Res 68(19): 8137-8145.
  10. Lung, H. L., Lo, P. H., Xie, D., Apte, S. S., Cheung, A. K., Cheng, Y., Law, E. W., Chua, D., Zeng, Y. X., Tsao, S. W., Stanbridge, E. J. and Lung, M. L. (2008). Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma. Int J Cancer 123(2): 401-408.
  11. Lung, H. L., Lo, C. C., Wong, C. C., Cheung, A. K., Cheong, K. F., Wong, N., Kwong, F. M., Chan, K. C., Law, E. W., Tsao, S. W., Chua, D., Sham, J. S., Cheng, Y., Stanbridge, E. J., Robertson, G. P. and Lung, M. L. (2008). Identification of tumor suppressive activity by irradiation microcell-mediated chromosome transfer and involvement of alpha B-crystallin in nasopharyngeal carcinoma. Int J Cancer 122(6): 1288-1296.
  12. Lung, H. L., Cheung, A. K., Xie, D., Cheng, Y., Kwong, F. M., Murakami, Y., Guan, X. Y., Sham, J. S., Chua, D., Protopopov, A. I., Zabarovsky, E. R., Tsao, S. W., Stanbridge, E. J. and Lung, M. L. (2006). TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma. Cancer Res 66(19): 9385-9392.
  13. Lung, H. L., Bangarusamy, D. K., Xie, D., Cheung, A. K., Cheng, Y., Kumaran, M. K., Miller, L., Liu, E. T., Guan, X. Y., Sham, J. S., Fang, Y., Li, L., Wang, N., Protopopov, A. I., Zabarovsky, E. R., Tsao, S. W., Stanbridge, E. J. and Lung, M. L. (2005). THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma. Oncogene 24(43): 6525-6532.
  14. Lung, H. L., Cheng, Y., Kumaran, M. K., Liu, E. T., Murakami, Y., Chan, C. Y., Yau, W. L., Ko, J. M., Stanbridge, E. J. and Lung, M. L. (2004). Fine mapping of the 11q22-23 tumor suppressive region and involvement of TSLC1 in nasopharyngeal carcinoma. Int J Cancer 112(4): 628-635.
Protocols by Hong Lok Lung
  1. In vivo Matrigel Plug Angiogenesis Assay