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Scott Stibitz


Ph.D., Department of Biochemistry, University of Wisconsin at Madison, 1983

Current position

Chief, Laboratory of Enteric and Sexually Transmitted Diseases, CBER/FDA (January 2011 - present)

Publications (since 2005)

Peer reviewed research publications

  1. Plaut, R. D., Mocca, C. P., Prabhakara, R., Merkel, T. J. and Stibitz, S. (2013). Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging. PLoS One 8(3): e59232.
  2.  Boulanger, A., Chen, Q., Hinton, D. M. and Stibitz, S. (2013). In vivo phosphorylation dynamics of the Bordetella pertussis virulence-controlling response regulator BvgA. Mol Microbiol 88(1): 156-172.
  3.  Prabhakara, R., Foreman, O., De Pascalis, R., Lee, G. M., Plaut, R. D., Kim, S. Y., Stibitz, S., Elkins, K. L. and Merkel, T. J. (2013). Epicutaneous model of community-acquired Staphylococcus aureus skin infections. Infect Immun 81(4): 1306-1315.
  4.  Verma, A., McNichol, B., Domínguez-Castillo, R. I., Amador-Molina, J. C., Arciniega, J. L., Reiter, K., Meade, B. D., Ngundi, M. M., Stibitz, S. and Burns, D. L. (2013). Use of Site-Directed Mutagenesis To Model the Effects of Spontaneous Deamidation on the Immunogenicity of Bacillus anthracis Protective Antigen. Infection and immunity 81(1): 278-284
  5.  Bishop-Lilly, K. A., Plaut, R. D., Chen, P. E., Akmal, A., Willner, K. M., Butani, A., Dorsey, S., Mokashi, V., Mateczun, A. J., Chapman, C., George, M., Luu, T., Read, T. D., Calendar, R., Stibitz, S. and Sozhamannan, S. (2012). Whole genome sequencing of phage resistant Bacillus anthracis mutants reveals an essential role for cell surface anchoring protein CsaB in phage AP50c adsorption. Virol J 9: 246.
  6.  Plaut, R. D., Kelly, V. K., Lee, G. M., Stibitz, S. and Merkel, T. J. (2012). Dissemination bottleneck in a murine model of inhalational anthrax. Infect Immun 80(9): 3189-3193.
  7.  Tonry, J. H., McNichol, B. A., Ramarao, N., Chertow, D. S., Kim, K. S., Stibitz, S., Schneewind, O., Kashanchi, F., Bailey, C. L. and Popov, S. (2012). Bacillus anthracis protease InhA regulates BslA‐mediated adhesion in human endothelial cells. Cellular Microbiology 14(8): 1219-1230.
  8.  Nicholson, T. L., Brockmeier, S. L., Loving, C. L., Register, K. B., Kehrli, M. E., Stibitz, S. E. and Shore, S. M. (2012). Phenotypic modulation of the virulent Bvg phase is not required for pathogenesis and transmission of Bordetella bronchiseptica in swine. Infection and immunity 80(3): 1025-1036.
  9.  Crawford, M. A., Lowe, D. E., Fisher, D. J., Stibitz, S., Plaut, R. D., Beaber, J. W., Zemansky, J., Mehrad, B., Glomski, I. J. and Strieter, R. M. (2011). Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis. Proceedings of the National Academy of Sciences 108(41): 17159-17164.
  10.  Decker, K. B., Chen, Q., Hsieh, M. L., Boucher, P., Stibitz, S. and Hinton, D. M. (2011). Different requirements for sigma Region 4 in BvgA activation of the Bordetella pertussis promoters Pfim3 and PfhaB. J Mol Biol 409(5): 692-709.
  11.  Chen, Q., Decker, K. B., Boucher, P. E., Hinton, D. and Stibitz, S. (2010). Novel architectural features of Bordetella pertussis fimbrial subunit promoters and their activation by the global virulence regulator BvgA. Molecular microbiology 77(5): 1326-1340.
  12.  Inatsuka, C. S., Xu, Q., Vujkovic-Cvijin, I., Wong, S., Stibitz, S., Miller, J. F. and Cotter, P. A. (2010). Pertactin is required for Bordetella species to resist neutrophil-mediated clearance. Infection and immunity 78(7): 2901-2909.
  13.  Cybulski, R. J., Jr., Sanz, P., Alem, F., Stibitz, S., Bull, R. L. and O'Brien, A. D. (2009). Four superoxide dismutases contribute to Bacillus anthracis virulence and provide spores with redundant protection from oxidative stress. Infect Immun 77(1): 274-285.
  14.  Loving, C. L., Khurana, T., Osorio, M., Lee, G. M., Kelly, V. K., Stibitz, S. and Merkel, T. J. (2009). Role of anthrax toxins in dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol challenge model. Infect Immun 77(1): 255-265.
  15.  Verma, A., Wagner, L., Stibitz, S., Nguyen, N., Guerengomba, F. and Burns, D. L. (2008). Role of the N-terminal amino acid of Bacillus anthracis lethal factor in lethal toxin cytotoxicity and its effect on the lethal toxin neutralization assay. Clin Vaccine Immunol 15(11): 1737-1741.
  16.  Goebel, E. M., Wolfe, D. N., Elder, K., Stibitz, S. and Harvill, E. T. (2008). O antigen protects Bordetella parapertussis from complement. Infection and immunity 76(4): 1774-1780.
  17.  Brahmbhatt, T. N., Janes, B. K., Stibitz, E. S., Darnell, S. C., Sanz, P., Rasmussen, S. B. and O'Brien, A. D. (2007). Bacillus anthracis exosporium protein BclA affects spore germination, interaction with extracellular matrix proteins, and hydrophobicity. Infection and immunity 75(11): 5233-5239.
  18.  Janes, B. K. and Stibitz, S. (2006). Routine markerless gene replacement in Bacillus anthracis. Infect Immun 74(3): 1949-1953.
  19.  Jones, A. M., Boucher, P. E., Williams, C. L., Stibitz, S. and Cotter, P. A. (2005). Role of BvgA phosphorylation and DNA binding affinity in control of Bvg-mediated phenotypic phase transition in Bordetella pertussis. Mol Microbiol 58(3): 700-713.
  20.  Williams, C. L., Boucher, P. E., Stibitz, S. and Cotter, P. A. (2005). BvgA functions as both an activator and a repressor to control Bvgi phase expression of bipA in Bordetella pertussis. Molecular microbiology 56(1): 175-188.
  21. Veal-Carr, W. L. and Stibitz, S. (2005). Demonstration of differential virulence gene promoter activation in vivo in Bordetella pertussis using RIVET. Mol Microbiol 55(3): 788-798.

Invited book chapters, reviews, and meeting proceedings

  1.  Decker, K. B., James, T. D., Stibitz, S. and Hinton, D. M. (2012). The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA. Microbiology 158(Pt 7): 1665-1676.
  2.  Janes, B. K. and Stibitz, S. (2011). Genetic Manipulation Methods in Bacillus anthracis. Bacillus anthracis and Anthrax: 53-66.
  3.  Cotter, P. A. and Stibitz, S. (2007). c-di-GMP-mediated regulation of virulence and biofilm formation. Curr Opin Microbiol 10(1): 17-23.
  4.  Stibitz, S. (2006) The bvgASR locus of Bordetella pertussis. In: C. Locht (ed.) Bordetella Molecular Biology. Horizon Scientific Press.
Protocols by Scott Stibitz
  1. Separation and Detection of Phosphorylated and Nonphosphorylated BvgA, a Bordetella pertussis Response Regulator, in vivo and in vitro