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(ol) 1.4 (l) 1.5 (o) 6.1 (w) 4.5 (i) 1.4 (ng\040p) 6.1 (r) -1.3 (ot) 3.5 (o) 6.2 (c) -2 (ol) 1.4 (\040) 5.8 (has) -2 (\040) 5.8 (bee) 6.1 (n\040m) 1.6 (o) 6.2 (di) 1.4 (f) 3.6 (i) 1.4 (ed) ] TJ 0 Tc 0 Tw 18.605 0 Td (\040) Tj 0.001 Tc -0.003 Tw -43.114 -1.725 Td [ (f) 3.6 (r) -1.4 (om) 1.6 (\040) 0.6 (a\040) 0.6 (publ) 1.5 (i) 7.4 (s) 4 (hed\040) 0.5 (v) 4 (er) 4.7 (s) -2 (i) 1.5 (on\040) ] TJ 0 Tc 0 Tw 11.15 0 Td (\050) Tj EMC /Reference << /MCID 9 >> BDC -0.005 Tc 0.005 Tw 0.329 0 Td [ (F) -4.8 (r) -7.3 (a) -5.9 (nk) -8 (en) -5.9 (\040) ] TJ /TT4 1 Tf 0.001 Tc -0.003 Tw 3.94 0 Td [ (et) 3.6 (\040) 0.5 (al) 1.5 (\056) ] TJ /TT2 1 Tf 0 Tc 0 Tw 2.162 0 Td (\054) Tj 0.275 0 Td (\040) Tj 0.001 Tc -0.001 Tw 0.275 0 Td (2006) Tj EMC /Span << /MCID 10 >> BDC 0 Tc 0 Tw (\051) Tj 2.563 0 Td (\056) Tj /TT3 1 Tf 0.269 0 Td (\040) Tj EMC /P << /MCID 11 >> BDC /TT2 1 Tf -20.964 -1.719 Td (\040) Tj EMC ET /P << /MCID 12 >> BDC BT /TT3 1 Tf 0.001 Tc -0.003 Tw 10.02 0 0 10.02 90 465.06 Tm [ (M) 1.7 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Tc 0 Tw 7.162 0 Td (\040) Tj 0.001 Tc -0.001 Tw 0.275 0 Td [ (2) 6.1 (5200) ] TJ 0 Tc 0 Tw 2.772 0 Td (\055) Tj -0.005 Tc 0.005 Tw 0.335 0 Td [ (0) -5.9 (56) ] TJ 0 Tc 0 Tw 1.665 0 Td (\051) Tj 0.329 0 Td (\040) Tj EMC /LBody << /MCID 32 >> BDC 0.001 Tc -0.001 Tw -35.731 -1.725 Td (5\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj -0.001 Tc -0.001 Tw 0.952 0 Td [ (C) -3.6 (r) -3.3 (y) 2 (s) -4 (t) 1.5 (a) -1.9 (l\040) 0.5 (v) 2 (i) -0.6 (o) -1.9 (le) -1.9 (t) ] TJ 0 Tc 0 Tw 5.719 0 Td (\040) Tj 0.269 0 Td (\050) Tj -0.001 Tc 0.001 Tw 0.335 0 Td [ (S) 1.3 (ig) -1.9 (ma) ] TJ 0 Tc 0 Tw 2.826 0 Td (\055) Tj 0.001 Tc -0.003 Tw 0.335 0 Td [ (A) 3.3 (l) 1.5 (dr) -1.3 (i) 7.4 (c) 4 (h\054) 3.5 (\040) 0.6 (c) -2 (at) 3.6 (al) 1.4 (og\040) 0.5 (n) 6.1 (u) 6.1 (m) 1.7 (ber) -1.3 (\072) 3.6 (\040) ] TJ -0.001 Tw 11.036 0 Td [ (C) 4.5 (388) 6.1 (6) ] TJ 0 Tc 0 Tw (\051) Tj 3.269 0 Td (\040) Tj EMC /LBody << /MCID 36 >> BDC 0.001 Tc -0.001 Tw -25.575 -1.719 Td (6\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj -0.001 Tc 0.001 Tw 0.952 0 Td (Me) Tj 0.001 Tc -0.001 Tw 1.389 0 Td [ (t) 3.6 (hanol) ] TJ 0 Tc 0 Tw 2.725 0 Td (\040) Tj 0.269 0 Td (\050) Tj -0.001 Tc 0.001 Tw 0.335 0 Td [ (S) 1.3 (ig) -1.9 (ma) ] TJ 0 Tc 0 Tw 2.832 0 Td (\055) Tj 0.001 Tc -0.003 Tw 0.335 0 Td [ (A) 3.3 (l) 1.5 (d) 6.1 (r) -1.3 (i) 7.4 (c) -2 (h\054) 3.6 (\040) 0.6 (c) -2 (at) 3.5 (al) 1.4 (o) 6.1 (g\040) 0.6 (num) 1.7 (b) 6.1 (er) -1.3 (\072) 3.6 (\040) ] TJ -0.001 Tw 11.036 0 Td [ (3486) 6.1 (0) ] TJ 0 Tc 0 Tw (\051) Tj 3.108 0 Td (\040) Tj EMC /LBody << /MCID 40 >> BDC 0.001 Tc -0.001 Tw -23.814 -1.725 Td (7\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.952 0 Td (G) Tj 0.001 Tc -0.001 Tw [ (l) 1.4 (ac) -2 (i) 7.5 (al) ] TJ 0 Tc 0 Tw 3.054 0 Td (\040) Tj 0.001 Tc -0.003 Tw 0.275 0 Td [ (ac) 4 (et) 3.6 (i) 1.5 (c) 4 (\040) 0.5 (ac) -2 (i) 1.5 (d) ] TJ 0 Tc 0 Tw (\040) Tj 4.994 0 Td (\050) Tj -0.007 Tc 0.007 Tw 0.335 0 Td [ (S) -4.7 (i) -6.5 (g) -7.9 (ma) ] TJ 0 Tc 0 Tw 2.826 0 Td (\055) Tj 0.001 Tc -0.003 Tw 0.329 0 Td [ (A) 3.3 (l) 1.5 (dr) -1.3 (i) 1.4 (c) 4 (h\054) 3.5 (\040) 0.6 (c) -2 (at) 3.6 (al) 7.4 (og\040) 0.5 (num) 1.7 (b) 6.1 (er) -1.3 (\072) 3.6 (\040) ] TJ -0.001 Tw 11.042 0 Td [ (3) 6.1 (2009) 6.1 (9) ] TJ 0 Tc 0 Tw (\051) Tj 3.659 0 Td (\040) Tj EMC /LBody << /MCID 44 >> BDC 0.001 Tc -0.001 Tw -28.299 -1.719 Td (8\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.952 0 Td (F) Tj 0.001 Tc -0.003 Tw [ (i) 1.5 (x) 4 (at) 3.6 (i) 1.4 (on\040) 0.5 (s) -2 (ol) 1.5 (ut) 3.6 (i) 7.4 (on) ] TJ 0 Tc 0 Tw 7.21 0 Td (\040) Tj EMC /LBody << /MCID 48 >> BDC 0.001 Tc -0.001 Tw -8.994 -1.725 Td (9\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.001 Tc -0.003 Tw 0.952 0 Td [ (C) -1.5 (ol) 1.4 (o) 6.1 (ny) 4 (\040) 0.5 (f) 3.6 (i) 1.4 (x) 4 (at) ] TJ 5.21 0 Td [ (i) 1.5 (on\040) 0.5 (s) -1.9 (ol) 1.4 (ut) 3.5 (i) 1.5 (o) 6.1 (n) ] TJ 0 Tc 0 Tw (\040) Tj EMC /Span << /MCID 49 >> BDC -0.005 Tc 0.003 Tw 5.329 0 Td [ (\050) -7.3 (s) -2 (ee) -5.9 (\040) 0.5 (R) -7.5 (ec) -8 (i) -4.6 (p) -5.9 (es) -8 (\051) ] TJ EMC /Span << /MCID 50 >> BDC 0 Tc 0 Tw 6.156 0 Td (\040) Tj EMC /LBody << /MCID 54 >> BDC 0.001 Tc -0.001 Tw -18.479 -1.719 Td (10\056) Tj 0 Tc 0 Tw 1.389 0 Td (\040) Tj 0.395 0 Td (C) Tj -0.001 Tc -0.007 Tw 0.725 0 Td [ (r) -3.3 (y) 2 (s) -4 (t) 1.5 (a) -1.9 (l) -0.6 (\040) -5.4 (v) 2 (i) -0.6 (o) -1.9 (le) -1.9 (t) 1.5 (\040) 0.5 (s) -4 (o) -1.9 (lu) -1.9 (t) 1.5 (io) 4 (n) ] TJ 0 Tc 0 Tw 8.707 0 Td (\040) Tj EMC /Span << /MCID 55 >> BDC 0.001 Tc -0.009 Tw 0.275 0 Td [ (\050) -1.3 (s) 4 (ee\040) 0.6 (R) -1.6 (e) 6.1 (c) -2 (i) 1.5 (pe) 6.1 (s) -2 (\051) ] TJ EMC /Span << /MCID 56 >> BDC 0 Tc 0 Tw 6.156 0 Td (\040) Tj EMC /P << /MCID 59 >> BDC -19.425 -1.725 Td (\040) Tj EMC ET /P << /MCID 60 >> BDC BT /TT3 1 Tf 10.02 0 0 10.02 90 240.84 Tm [ (E) 2.3 (qui) 2.5 (pm) 2.8 (e) -0.9 (nt) ] TJ 5.156 0 Td (\040) Tj ET 90 238.68 51.66 1.08 re f* EMC BT /P << /MCID 61 >> BDC /TT2 1 Tf 10.02 0 0 10.02 90 223.68 Tm (\040) Tj EMC /LBody << /MCID 64 >> BDC 0.001 Tc -0.001 Tw 1.778 -1.725 Td (1\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj -0.001 Tc 0.059 Tw 0.952 0 Td [ (C) -3.6 (e) -1.8 (l) -0.6 (l) -0.6 (\040) 0.7 (c) -4 (u) -1.9 (l) -0.6 (t) 1.6 (u) 4.1 (r) -3.4 (e) -1.9 (\040) 0.7 (p) 4.1 (e) -1.9 (t) 1.5 (r) -3.3 (i\040) 0.6 (d) -1.9 (is) -4 (h) 4 (e) -1.8 (s) -4 (\040) 0.6 (o) 4.1 (r) 2.7 (\040) 0.6 (s) -4 (ix) ] TJ 0 Tc 0 Tw 13.335 0 Td (\055) Tj 0.001 Tc 0.057 Tw 0.335 0 Td [ (w) -1.5 (el) 1.4 (l) 1.5 (\040) 0.7 (pl) 7.4 (at) 3.6 (e) 6.1 (s) ] TJ 0 Tc 0 Tw 4.719 0 Td (\040) Tj 0.335 0 Td (\050) Tj 0.001 Tc 0.057 Tw 0.335 0 Td [ (T) 1.2 (h) 6.1 (er) -1.4 (m) 7.7 (o\040) 0.7 (F) 1.2 (i) 1.5 (s) -2 (he) 6.1 (r) -1.3 (\040) 0.7 (S) 3.3 (c) -2 (i) 1.5 (e) 6.1 (nt) 3.6 (i) 1.4 (f) 3.6 (i) 1.4 (c) -2 (\054) 3.6 (\040) 0.7 (c) -2 (at) 3.6 (al) 1.4 (o) 6.2 (g\040) 0.7 (nu) 6.1 (m) 1.7 (ber) -1.3 (\072) 3.5 (\040) ] TJ -0.001 Tw 19.048 0 Td (08) Tj 0 Tc 0 Tw 1.108 0 Td (\055) Tj 0.001 Tc -0.001 Tw -39.216 -1.719 Td (772) Tj 0 Tc 0 Tw (\055) Tj 0.001 Tc -0.001 Tw 2 0 Td (1B) Tj 0 Tc 0 Tw 1.222 0 Td (\051) Tj 0.329 0 Td (\040) Tj EMC /LBody << /MCID 68 >> BDC 0.001 Tc -0.001 Tw -5.335 -1.725 Td (2\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.001 Tc -0.001 Tw 0.952 0 Td [ (H) -1.5 (em) 1.6 (o) 6.1 (c) -1.9 (y) 4 (t) 3.5 (om) 1.7 (e) 6.1 (t) 3.6 (er) ] TJ 0 Tc 0 Tw 7.048 0 Td (\040) Tj 0.001 Tc 0.242 Tw 0.521 0 Td [ (\050) 4.7 (H) -1.6 (au) 6.2 (s) 4 (s) -2 (e) 6.1 (r) 4.7 (\040B) 3.3 (r) -1.3 (i) 1.5 (ght) ] TJ 0 Tc 0 Tw 7.174 0 Td (\055) Tj 0.001 Tc -0.001 Tw 0.329 0 Td [ (Li) 1.5 (ne) ] TJ -0.004 Tc 0.247 Tw 1.886 0 Td (\051\040\050) Tj 0.001 Tc 0.242 Tw 1.186 0 Td [ (T) 1.2 (he) 6.1 (r) -1.4 (m) 1.7 (o\040) 6.1 (F) 1.2 (i) 7.4 (s) -1.9 (he) 6.1 (r) -1.3 (\040S) 3.3 (c) -1.9 (i) 7.4 (ent) 3.6 (i) 1.5 (f) 3.5 (i) 1.5 (c) -2 (\054) 3.5 (\040c) -2 (at) 3.6 (al) 7.4 (og\040n) 6.1 (um) 1.6 (be) 6.1 (r) -1.4 (\072) ] TJ 0 Tc 0 Tw 19.443 0 Td (\040) Tj 0.521 0 Td (0) Tj 0.557 0 Td (2) Tj 0.551 0 Td (\055) Tj 0.001 Tc -0.001 Tw -39.216 -1.719 Td (671) Tj 0 Tc 0 Tw (\055) Tj 0.001 Tc -0.001 Tw 2 0 Td (10) Tj 0 Tc 0 Tw 1.108 0 Td (\051) Tj 0.329 0 Td (\040) Tj EMC /LBody << /MCID 72 >> BDC 0.001 Tc -0.001 Tw -5.222 -1.725 Td (3\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.001 Tc -0.001 Tw 0.952 0 Td [ (S) 3.3 (t) 3.6 (er) -1.3 (eom) 1.7 (i) 7.4 (c) -1.9 (r) 4.6 (os) 4 (c) -1.9 (op) 6.1 (e) ] TJ 0 Tc 0 Tw (\040) Tj 8.323 0 Td (\050) Tj /TT4 1 Tf -0.002 Tc 0.002 Tw 0.335 0 Td [ (e) -2.9 (\056) 0.6 (g) -2.9 (\056) 0.5 (\054) ] TJ /TT2 1 Tf 0 Tc 0 Tw 1.94 0 Td (\040) Tj 0.001 Tc -0.003 Tw 0.275 0 Td [ (N) -1.5 (i) 7.4 (k) -2 (on\040) 0.5 (E) 3.3 (c) -1.9 (l) 1.4 (i) 7.4 (ps) 4 (e) ] TJ 0 Tc 0 Tw (\054) Tj 6.323 0 Td (\040) Tj 0.001 Tc -0.001 Tw 0.275 0 Td [ (m) 1.7 (odel) 1.5 (\072) 3.5 (\040) ] TJ 3.275 0 Td [ (T) 1.2 (S) 3.4 (10) 6.1 (0\051) ] TJ 0 Tc 0 Tw 3.269 0 Td (\040) Tj EMC /LBody << /MCID 76 >> BDC 0.001 Tc -0.001 Tw -25.802 -1.719 Td (4\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.001 Tc -0.001 Tw 0.952 0 Td [ (H) -1.5 (em) 1.6 (o) 6.2 (c) -2 (y) 4 (t) 3.5 (om) 1.6 (e) 6.1 (t) 3.6 (er) ] TJ 0 Tc 0 Tw 7.042 0 Td (\040) Tj EMC /LBody << /MCID 80 >> BDC 0.001 Tc -0.001 Tw -8.826 -1.725 Td (5\056) Tj 0 Tc 0 Tw 0.832 0 Td (\040) Tj 0.952 0 Td (I) Tj 0.001 Tc -0.001 Tw 0.275 0 Td [ (nc) -2 (ub) 6.2 (at) 3.5 (or) ] TJ 0 Tc 0 Tw 3.886 0 Td (\040) Tj EMC /P << /MCID 83 >> BDC -7.725 -1.719 Td (\040) Tj EMC /Artifact << /Attached [ /Bottom ] /BBox [ 83.184 46.656 529.14 72.78 ] /Subtype /Footer /Type /Pagination >> BDC 7.98 0 0 7.98 90 63.42 Tm [ (Cop) -7.9 (y) 3.7 (r) 2.2 (i) -3.5 (ght\040\251\040201) ] TJ 7.256 0 Td (2) Tj (\040) Tj [ (T) 2 (he\040A) -2.2 (utho) -7.9 (r) 2.1 (s) -3.7 (\073\040e) -7.9 (x) 3.7 (c) -3.7 (l) -3.6 (us) -3.8 (i) -3.5 (v) -3.8 (e\040l) 4 (i) -3.6 (c) -3.7 (ens) -3.8 (ee) 7.2 (\040B) -2.2 (i) -3.6 (o) ] TJ (\055) Tj 16.992 0 Td [ (pr) 2.2 (otoc) -3.8 (ol) -3.5 (\040LL) -7.9 (C\056) ] TJ (\040) Tj 9 0 0 9 508.2 63.42 Tm (1) Tj 7.98 0 0 7.98 513.18 63.42 Tm (\040) Tj /TT5 1 Tf 12 0 0 12 90 50.34 Tm (\040) Tj EMC ET Q q 1 0 0 1 0 0 cm BT /F1 12 Tf 14.4 TL ET 0.1 w 0.5 0.5 0.5 RG n 72 813.6 452.88 21.6 re S q 1 0 0 1 0 817 cm q BT 1 0 0 1 75 1.5 Tm 8 TL /F2 6.5 Tf 0 0 0 rg (Please\040cite\040this\040article\040as\072) Tj /F1 6.5 Tf (\040Xiaodong\054\040\0502012\051\056\040Clonogenic\040Assay\054\040) Tj /F3 6.5 Tf (Bio\055protocol) Tj /F1 6.5 Tf (\0402\040\05010\051\072\040e187\056\040DOI\072\04010\05621769\057BioProtoc\056187\056) Tj T* ET Q Q Q endstream endobj 12 0 obj << /AIS false /BM /Normal /CA 1 /OP false /OPM 1 /SA true /SMask /None /Type /ExtGState /ca 1 /op false >> endobj 13 0 obj << /BaseFont /RBFDSP+Cambria /Encoding /WinAnsiEncoding /FirstChar 32 /FontDescriptor 14 0 R /LastChar 32 /Subtype /TrueType /ToUnicode 16 0 R /Type /Font /Widths [ 220 ] >> endobj 14 0 obj << /Ascent 3117 /CapHeight 667 /Descent -2464 /Flags 34 /FontBBox [ -1475 -2464 2868 3117 ] /FontFamily (Cambria) /FontFile2 15 0 R /FontName /RBFDSP+Cambria /FontStretch /Normal /FontWeight 400 /ItalicAngle 0 /StemV 84 /Type /FontDescriptor /XHeight 467 >> endobj 15 0 obj << /Filter /FlateDecode /Length1 78708 /Length 27611 >> stream HԖyTUGƿb"*