Education
Ph.D. in Genetics, Department of Neurogenetics, University of Wuerzburg, Germany, 1989
Current Position
Associate Professor, Department of Physiology, National University of Singapore, Singapore
Publications (since 2005)
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Moh, M. C., Lorenzini, P. A., Gullo, C. and Schwarz, H. (2013). Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling. FASEB J. [Epub ahead of print]
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Tang, Q., Jiang, D., Alonso, S., Pant, A., Martinez Gomez, J. M., Kemeny, D. M., Chen, L. and Schwarz, H. (2013). CD137 ligand signaling enhances myelopoiesis during infections. Eur J Immunol. [Epub ahead of print]
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Ho, W. T., Pang, W. L., Chong, S. M., Castella, A., Al-Salam, S.,
Tan, T. E., Moh, M. C., Koh, L. K., Gan, S. U., Cheng, C. K. and
Schwarz, H. (2013). Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression. Cancer Res 73(2): 652-661.
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Martinez Gomez, J. M., Croxford, J. L., Yeo, K. P., Angeli, V., Schwarz, H. and Gasser, S. (2012). Development of experimental autoimmune encephalomyelitis critically depends on CD137 ligand signaling. J Neurosci 32(50): 18246-18252.
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Yeo, Y. A., Martinez Gomez, J. M., Croxford, J. L., Gasser, S., Ling, E. A. and Schwarz, H. (2012). CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species. J Neuroinflammation 9: 173.
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Ong, S. M., Tan, Y. C., Beretta, O., Jiang, D., Yeap, W. H., Tai, J. J.,
Wong, W. C., Yang, H., Schwarz, H., Lim, K. H., Koh, P. K., Ling, K. L.
and Wong, S. C. (2012). Macrophages
in human colorectal cancer are pro-inflammatory and prime T cells
towards an anti-tumour type-1 inflammatory response. Eur J Immunol 42(1): 89-100.
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Jiang, D., Tang, Q. and Schwarz, H. (2011). Involvement of the cytokine receptor CD137 in murine hematopoiesis. Adv Exp Med Biol 691: 375-382.
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Shao, Z. and Schwarz, H. (2011). CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction. J Leukoc Biol 89(1): 21-29.
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S Shao, Z., Schaffler, A., Hamer, O., Dickopf, J., Goetz, A., Landfried,
K., Voelk, M., Kopp, A., Herfarth, H., Karrasch, T., Brunnler, T., Koh,
L. K., Buechler, C. and Schwarz, H. (2012). Admission
levels of soluble CD137 are increased in patients with acute
pancreatitis and are associated with subsequent complications. Exp Mol Pathol 92(1): 1-6.
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Kwajah, M. M. S., Mustafa, N., Holme, A. L., Pervaiz, S. and Schwarz, H. (2011). Biphasic activity of CD137 ligand-stimulated monocytes on T cell apoptosis and proliferation. J Leukoc Biol 89(5): 707-720.
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Tang, Q., Jiang, D., Shao, Z., Martinez Gomez, J. M. and Schwarz, H. (2011). Species difference of CD137 ligand signaling in human and murine monocytes. PLoS One 6(1): e16129.
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Jiang, D. and Schwarz, H. (2010). Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein. PLoS One 5(12): e15565.
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Kwajah, M. M. S. and Schwarz, H. (2010). CD137 ligand signaling induces human monocyte to dendritic cell differentiation. Eur J Immunol 40(7): 1938-1949.
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Gullo, C., Koh, L. K., Pang, W. L., Ho, K. T., Tan, S. H. and Schwarz, H. (2010). Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling. PLoS One 5(5): e10845.
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Quek, B. Z., Lim, Y. C., Lin, J. H., Tan, T. E., Chan, J., Biswas, A. and Schwarz, H. (2010). CD137 enhances monocyte-ICAM-1 interactions in an E-selectin-dependent manner under flow conditions. Mol Immunol 47(9): 1839-1847.
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Thum, E., Shao, Z. and Schwarz, H. (2009). CD137, implications in immunity and potential for therapy. Front Biosci 14: 4173-4188.
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Wang, Z., Chen, C., Finger, S. N., Kwajah, S., Jung, M., Schwarz, H., Swanson, N., Lareu, F. F. and Raghunath, M. (2009). Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis? Eur Respir J 34(1): 145-155.
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Jiang, D., Chen, Y. and Schwarz, H. (2008). CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol 181(6): 3923-3932.
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Jiang, D., Yue, P. S., Drenkard, D. and Schwarz, H. (2008). Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Stem Cells 26(9): 2372-2381.
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hao, Z., Sun, F., Koh, D. R. and Schwarz, H. (2008). Characterisation of soluble murine CD137 and its association with systemic lupus. Mol Immunol 45(15): 3990-3999.
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Lippert, U., Zachmann, K., Ferrari, D. M., Schwarz, H., Brunner, E., Latif, A., Neumann, C. and Soruri, A. (2008). CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response. Eur J Immunol 38(4): 1024-1032.
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Sollner, L., Shaqireen, D. O. K. M. M., Wu, J. T. and Schwarz, H. (2007). Signal transduction mechanisms of CD137 ligand in human monocytes. Cell Signal 19(9): 1899-1908.
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Drenkard, D., Becke, F. M., Langstein, J., Spruss, T., Kunz-Schughart, L. A., Tan, T. E., Lim, Y. C. and Schwarz, H. (2007). CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. FASEB J 21(2): 456-463.
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Schwarz H. Significance of reverse signal transduction for the biology of the CD137 receptor/ligand system. In: Chen LP (Ed.). CD137/4-1BB Pathway in Immune Responses and Diseases. Kluwer Academic/Plenum Publishers 2006.
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Yu, Q., Yue, F. Y., Gu, X. X., Schwartz, H., Kovacs, C. M. and Ostrowski, M. A. (2006). OX40
ligation of CD4+ T cells enhances virus-specific CD8+ T cell memory
responses independently of IL-2 and CD4+ T regulatory cell inhibition. J Immunol 176(4): 2486-2495.
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Ierna, M. X., Scales, H. E., Schwarz, H., Bunce, C., McIlgorm, A., Garside, P. and Lawrence, C. E. (2006). OX40 interactions in gastrointestinal nematode infection. Immunology 117(1): 108-116.
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Reali C, Scintu F, Pillai R, Curto M, Palmieri G, Marcialis MA, Schwarz H and Sogos V. Expression of Cytokines and Co-stimulatory Molecules by Activated Human Microglia. In Robert M Coleman (Ed.). Focus on Neurochemistry. Nova Science Publishers, Inc. 2005 pp 117- 40.
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Schwarz, H. (2005). Biological activities of reverse signal transduction through CD137 ligand. Journal of leukocyte biology 77(3): 281-286.
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Furtner, M., Straub, R. H., Kruger, S. and Schwarz, H. (2005). Levels
of soluble CD137 are enhanced in sera of leukemia and lymphoma patients
and are strongly associated with chronic lymphocytic leukemia. Leukemia 19(5): 883-885.