Improve Research Reproducibility A Bio-protocol resource
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ML
Mark R. Looney
  • Department of Medicine, University of California, San Francisco, USA
研究方向
  • Immunology
个人信息

Education

M.D., University of Tennessee, Memphis, TN, 1998

Current position

Associate Professor in Residence, Step 3 Medicine, School of Medicine, University of California, San Francisco, San Francisco, USA

Publications

Peer reviewed publications

  1. Bose, O., Baluk, P., Looney, M. R., Cheng, L. E., McDonald, D. M., Caughey, G. H. and Krummel, M. F. (2015). Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One 10(3): e0118513.
  2. Roubinian, N. H., Looney, M. R., Kor, D. J., Lowell, C. A., Gajic, O., Hubmayr, R. D., Gropper, M. A., Koenigsberg, M., Wilson, G. A., Matthay, M. A., Toy, P., Murphy, E. L. and the, T. S. G. (2015). Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. (Epub ahead of print)
  3. Vaughan, A. E., Brumwell, A. N., Xi, Y., Gotts, J. E., Brownfield, D. G., Treutlein, B., Tan, K., Tan, V., Liu, F. C., Looney, M. R., Matthay, M. A., Rock, J. R. and Chapman, H. A. (2015). Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature 517(7536): 621-625.
  4. Sayah, D. M., Mallavia, B., Liu, F., Ortiz-Munoz, G., Caudrillier, A., DerHovanessian, A., Ross, D. J., Lynch, J. P., 3rd, Saggar, R., Ardehali, A., Lung Transplant Outcomes Group, I., Ware, L. B., Christie, J. D., Belperio, J. A. and Looney, M. R. (2015). Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med 191(4): 455-463.
  5. Ortiz-Munoz, G., Mallavia, B., Bins, A., Headley, M., Krummel, M. F. and Looney, M. R. (2014). Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood 124(17): 2625-2634.
  6. Greenland, J. R., Xu, X., Sayah, D. M., Liu, F. C., Jones, K. D., Looney, M. R. and Caughey, G. H. (2014). Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction. Respir Res 15: 95.
  7. Looney, M. R., Roubinian, N., Gajic, O., Gropper, M. A., Hubmayr, R. D., Lowell, C. A., Bacchetti, P., Wilson, G., Koenigsberg, M., Lee, D. C., Wu, P., Grimes, B., Norris, P. J., Murphy, E. L., Gandhi, M. J., Winters, J. L., Mair, D. C., Schuller, R. M., Hirschler, N. V., Rosen, R. S., Matthay, M. A., Toy, P. and Transfusion-Related Acute Lung Injury Study, G. (2014). Prospective study on the clinical course and outcomes in transfusion-related acute lung injury. Crit Care Med 42(7): 1676-1687.
  8. Murphy, E. L., Kwaan, N., Looney, M. R., Gajic, O., Hubmayr, R. D., Gropper, M. A., Koenigsberg, M., Wilson, G., Matthay, M., Bacchetti, P., Toy, P. and Group, T. S. (2013). Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med 126(4): 357 e329-338.
  9. Caudrillier, A., Kessenbrock, K., Gilliss, B. M., Nguyen, J. X., Marques, M. B., Monestier, M., Toy, P., Werb, Z. and Looney, M. R. (2012). Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest 122(7): 2661-2671.
  10. Thornton, E. E., Looney, M. R., Bose, O., Sen, D., Sheppard, D., Locksley, R., Huang, X. and Krummel, M. F. (2012). Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med 209(6): 1183-1199.
  11. Weiskopf, R. B., Feiner, J., Toy, P., Twiford, J., Shimabukuro, D., Lieberman, J., Looney, M. R., Lowell, C. A. and Gropper, M. A. (2012). Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg 114(3): 511-519.
  12. Toy, P., Gajic, O., Bacchetti, P., Looney, M. R., Gropper, M. A., Hubmayr, R., Lowell, C. A., Norris, P. J., Murphy, E. L., Weiskopf, R. B., Wilson, G., Koenigsberg, M., Lee, D., Schuller, R., Wu, P., Grimes, B., Gandhi, M. J., Winters, J. L., Mair, D., Hirschler, N., Sanchez Rosen, R., Matthay, M. A. and Group, T. S. (2012). Transfusion-related acute lung injury: incidence and risk factors. Blood 119(7): 1757-1767.
  13. Kleinman, S. H., Triulzi, D. J., Murphy, E. L., Carey, P. M., Gottschall, J. L., Roback, J. D., Carrick, D., Mathew, S., Wright, D. J., Cable, R., Ness, P., Gajic, O., Hubmayr, R. D., Looney, M. R., Kakaiya, R. M., National Heart, L. and Blood Institute Retrovirus Epidemiology Donor, S., II (2011). The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components. Transfusion 51(10): 2078-2091.
  14. Su, X., Looney, M. R., Su, H. E., Lee, J. W., Song, Y. and Matthay, M. A. (2011). Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res 60(7): 619-632.
  15. Looney, M. R., Thornton, E. E., Sen, D., Lamm, W. J., Glenny, R. W. and Krummel, M. F. (2011). Stabilized imaging of immune surveillance in the mouse lung. Nat Methods 8(1): 91-96.
  16. Miniati, D., Jelin, E. B., Ng, J., Wu, J., Carlson, T. R., Wu, X., Looney, M. R. and Wang, R. A. (2010). Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol 298(2): L169-177.
  17. Looney, M. R., Nguyen, J. X., Hu, Y., Van Ziffle, J. A., Lowell, C. A. and Matthay, M. A. (2009). Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 119(11): 3450-3461.
  18. Klein, H. G., Glynn, S. A., Ness, P. M., Blajchman, M. A. and Components, N. W. G. o. R. O. f. t. P. R. I. o. B. (2009). Research opportunities for pathogen reduction/inactivation of blood components: summary of an NHLBI workshop. Transfusion 49(6): 1262-1268.
  19. Su, X., Looney, M. R., Gupta, N. and Matthay, M. A. (2009). Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol 297(1): L1-5.
  20. Looney, M. R., Esmon, C. T. and Matthay, M. A. (2009). Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax 64(2): 114-120.
  21. Su, X., Johansen, M., Looney, M. R., Brown, E. J. and Matthay, M. A. (2008). CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol 180(10): 6947-6953.
  22. Church, G. D., Price, C., Sanchez, R. and Looney, M. R. (2006). Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature. Transfus Med 16(5): 343-348.
  23. Looney, M. R., Su, X., Van Ziffle, J. A., Lowell, C. A. and Matthay, M. A. (2006). Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest 116(6): 1615-1623.
  24. Looney, M. R., Sartori, C., Chakraborty, S., James, P. F., Lingrel, J. B. and Matthay, M. A. (2005). Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol 289(1): L104-110.
  25. Su, X., Looney, M., Robriquet, L., Fang, X. and Matthay, M. A. (2004). Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res 30(6): 479-493.
  26. Looney, M. R., Dohan, F. C., Jr., Davies, K. G., Seidenberg, M., Hermann, B. P. and Schweitzer, J. B. (1999). Synaptophysin immunoreactivity in temporal lobe epilepsy-associated hippocampal sclerosis. Acta Neuropathol 98(2): 179-185.
  27. Davies, K. G., Schweitzer, J. B., Looney, M. R., Bush, A. J., Dohan, F. C., Jr. and Hermann, B. P. (1998). Synaptophysin immunohistochemistry densitometry measurement in resected human hippocampus: implication for the etiology of hippocampal sclerosis. Epilepsy Res 32(3): 335-344.

Review articles

  1. Lelkes, E., Headley, M. B., Thornton, E. E., Looney, M. R. and Krummel, M. F. (2014). The spatiotemporal cellular dynamics of lung immunity. Trends Immunol 35(8): 379-386.
  2. Looney, M. R. and Bhattacharya, J. (2014). Live imaging of the lung. Annu Rev Physiol 76: 431-445.
  3. Sayah, D. M., Looney, M. R. and Toy, P. (2012). Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury. Crit Care Clin 28(3): 363-372, v.
  4. Caudrillier, A. and Looney, M. R. (2012). Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury. Curr Pharm Des 18(22): 3260-3266.
  5. Gilliss, B. M., Looney, M. R. and Gropper, M. A. (2011). Reducing noninfectious risks of blood transfusion. Anesthesiology 115(3): 635-649.
  6. Gilliss, B. M. and Looney, M. R. (2011). Experimental models of transfusion-related acute lung injury. Transfus Med Rev 25(1): 1-11.
  7. Looney, M. R., Gilliss, B. M. and Matthay, M. A. (2010). Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol 17(5): 418-423.
  8. Looney, M. R. and Matthay, M. A. (2006). Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care 10(6): 239.
  9. Looney, M. R. (2006). Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza. Clin Chest Med 27(4): 591-600; abstract viii.
  10. Looney, M. R. and Matthay, M. A. (2006). Animal models of transfusion-related acute lung injury. Crit Care Med 34(5 Suppl): S132-136.
  11. Looney, M. R., Gropper, M. A. and Matthay, M. A. (2004). Transfusion-related acute lung injury: a review. Chest 126(1): 249-258.
  12. Looney, M. R. and Matthay, M. A. (2001). The role of protein C in sepsis. Curr Infect Dis Rep 3(5): 413-418.

Books and chapters

  1. Thornton, E. E., Krummel, M. F. and Looney, M. R. (2012). Live imaging of the lung. Curr Protoc Cytom Chapter 12: Unit12 28.
  2. Looney, M. R. and Gajic, O. (2009). Transfusion-related acute lung injury, in Choi AMK. In: Acute respiratory distress syndrome, 2nd edition. Informa health, 171-183.
  3. Popovsky, M. A., Toy, P. and Looney, M. R. (2008). The spectrum of pulmonary transfusion reactions. Transfusion-related acute lung injury, 1st edition. AABB press.
  4. Looney, M. R. and Jasmer, R. M. (2005). Airway management. In: Manual of clinical problems in pulmonary medicine, 6th edition.

Other publications

  1. Liu, K. D., Looney, M. R. and Matthay, M. A. (2009). Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care 13(3): 150.
  2. Looney, M. R. and Matthay, M. A. (2009). Neutrophil sandwiches injure the microcirculation. Nat Med 15(4): 364-366.
  3. Looney, M. R. (2008). Acute lung injury after blood product transfusion: are the times changing? Crit Care Med 36(6): 1968-1970.
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