Isabel Gordo
  • Evolutionary Biology Group, Instituto Gulbenkian de Ciência, Portugal
研究方向
  • Microbiology
个人信息

Education

Ph.D. in Evolutionary Genetics, University of Edinburgh, 2002

Current position

Principal Investigator of the Evolutionary Biology Group, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Publications (since 2005)

  1. Barroso-Batista, J., Sousa, A., Lourenco, M., Bergman, M. L., Sobral, D., Demengeot, J., Xavier, K. B. and Gordo, I. (2014). The first steps of adaptation of Escherichia coli to the gut are dominated by soft sweeps. PLoS Genet 10(3): e1004182.
  2. Sousa, A., Bourgard, C., Wahl, L. M. and Gordo, I. (2013). Rates of transposition in Escherichia coli. Biol Lett 9(6): 20130838.
  3. Miskinyte, M., Sousa, A., Ramiro, R. S., de Sousa, J. A., Kotlinowski, J., Caramalho, I., Magalhaes, S., Soares, M. P. and Gordo, I. (2013). The genetic basis of Escherichia coli pathoadaptation to macrophages. PLoS Pathog 9(12): e1003802.
  4. Sousa, A., Bourgard, C., Wahl, L. M. and Gordo, I. (2013). Rates of transposition in Escherichia coli. Biol Lett 9(6): 20130838.
  5. Chelo, I. M., Nedli, J., Gordo, I. and Teotonio, H. (2013). An experimental test on the probability of extinction of new genetic variants. Nat Commun 4: 2417.
  6. Perfeito, L., Sousa, A., Bataillon, T. and Gordo, I. (2014). Rates of fitness decline and rebound suggest pervasive epistasis. Evolution 68(1): 150-162.
  7. Avelar, A. T., Perfeito, L., Gordo, I. and Ferreira, M. G. (2013). Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy. Nat Commun 4: 2235.
  8. Moura de Sousa, J. A., Campos, P. R. and Gordo, I. (2013). An ABC method for estimating the rate and distribution of effects of beneficial mutations. Genome Biol Evol 5(5): 794-806.
  9. Miskinyte, M. and Gordo, I. (2013). Increased survival of antibiotic-resistant Escherichia coli inside macrophages. Antimicrob Agents Chemother 57(1): 189-195.
  10. Brito, P. H., Rocha, E. P., Xavier, K. B. and Gordo, I. (2013). Natural genome diversity of AI-2 quorum sensing in Escherichia coli: conserved signal production but labile signal reception. Genome Biol Evol 5(1): 16-30.
  11. Gordo, I. and Campos, P. R. (2013). Evolution of clonal populations approaching a fitness peak. Biol Lett 9(1): 20120239.
  12. Trindade, S., Sousa, A. and Gordo, I. (2012). Antibiotic resistance and stress in the light of Fisher's model. Evolution 66(12): 3815-3824.
  13. Sousa, A., Magalhaes, S. and Gordo, I. (2012). Cost of antibiotic resistance and the geometry of adaptation. Mol Biol Evol 29(5): 1417-1428.
  14. Silva, R. F., Mendonca, S. C., Carvalho, L. M., Reis, A. M., Gordo, I., Trindade, S. and Dionisio, F. (2011). Pervasive sign epistasis between conjugative plasmids and drug-resistance chromosomal mutations. PLoS Genet 7(7): e1002181.
  15. Gordo, I., Perfeito, L. and Sousa, A. (2011). Fitness effects of mutations in bacteria. J Mol Microbiol Biotechnol 21(1-2): 20-35.
  16. Brito, P. H., Guilherme, E., Soares, H. and Gordo, I. (2010). Mutation accumulation in Tetrahymena. BMC Evol Biol 10: 354.
  17. Gordo, I. and Sousa, A. (2010). Mutation, selection and genetic interactions in bacteria. eLS.
  18. Trindade, S., Perfeito, L. and Gordo, I. (2010). Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli. Philos Trans R Soc Lond B Biol Sci 365(1544): 1177-1186.
  19. Viana, D. S., Gordo, I., Sucena, E. and Moita, M. A. (2010). Cognitive and motivational requirements for the emergence of cooperation in a rat social game. PLoS One 5(1): e8483.
  20. Marais, G. A., Campos, P. R. and Gordo, I. (2010). Can intra-Y gene conversion oppose the degeneration of the human Y chromosome? A simulation study. Genome Biol Evol 2: 347-357.
  21. Charlesworth, B., Betancourt, A. J., Kaiser, V. B. and Gordo, I. (2009). Genetic recombination and molecular evolution. Cold Spring Harb Symp Quant Biol 74: 177-186.
  22. Trindade, S., Sousa, A., Xavier, K. B., Dionisio, F., Ferreira, M. G. and Gordo, I. (2009). Positive epistasis drives the acquisition of multidrug resistance. PLoS Genet 5(7): e1000578.
  23. Gordo, I., Gomes, M. G., Reis, D. G. and Campos, P. R. (2009). Genetic diversity in the SIR model of pathogen evolution. PLoS One 4(3): e4876.
  24. Campos, P. R., Neto, P. S., de Oliveira, V. M. and Gordo, I. (2008). Environmental heterogeneity enhances clonal interference. Evolution 62(6): 1390-1399.
  25. Gordo, I. and Campos, P. R. (2008). Sex and deleterious mutations. Genetics 179(1): 621-626.
  26. Perfeito, L., Pereira, M. I., Campos, P. R. and Gordo, I. (2008). The effect of spatial structure on adaptation in Escherichia coli. Biol Lett 4(1): 57-59.
  27. Perfeito, L., Fernandes, L., Mota, C. and Gordo, I. (2007). Adaptive mutations in bacteria: high rate and small effects. Science 317(5839): 813-815.
  28. Gordo, I. and Campos, P. R. (2007). Patterns of genetic variation in populations of infectious agents. BMC Evol Biol 7: 116.
  29. Gokaydin, D., Oliveira-Martins, J. B., Gordo, I. and Gomes, M. G. (2007). The reinfection threshold regulates pathogen diversity: the case of influenza. J R Soc Interface 4(12): 137-142.
  30. Dionisio, F. and Gordo, I. (2007). Controlling excludability in the evolution of cooperation. Evolutionary Ecology Research 9(2): 365-373.
  31. Combadao, J., Campos, P. R., Dionisio, F. and Gordo, I. (2007). Small-world networks decrease the speed of Muller's ratchet. Genet Res 89(1): 7-18.
  32. Campos, P. R. and Gordo, I. (2006). Pathogen genetic variation in small-world host contact structures. Journal of Statistical Mechanics: Theory and Experiment 2006(12): L12003.
  33. Campos, P. R., Combadão, J., Dionisio, F. and Gordo, I. (2006). Muller’s ratchet in random graphs and scale-free networks. Physical Review E 74(4): 042901.
  34. Faro, J., Combadao, J. and Gordo, I. (2006). Did germinal centers evolve under differential effects of diversity vs affinity? Artificial Immune Systems, Springer: 1-8.
  35. Perfeito, L., Gordo, I. and Campos, P. (2006). The effect of spatial structure in adaptive evolution. The European Physical Journal B-Condensed Matter and Complex Systems 51(2): 301-306.
  36. Gordo, I. and Campos, P. R. (2006). Adaptive evolution in a spatially structured asexual population. Genetica 127(1-3): 217-229.
  37. Dionisio, F. and Gordo, I. (2006). The tragedy of the commons, the public goods dilemma, and the meaning of rivalry and excludability in evolutionary biology. Evolutionary Ecology Research 8: 321-332.
  38. Rosas, A., Gordo, I. and Campos, P. R. (2005). Scaling, genetic drift, and clonal interference in the extinction pattern of asexual population. Phys Rev E Stat Nonlin Soft Matter Phys 72(1 Pt 1): 012901.
  39. Dionisio, F., Conceicao, I. C., Marques, A. C., Fernandes, L. and Gordo, I. (2005). The evolution of a conjugative plasmid and its ability to increase bacterial fitness. Biol Lett 1(2): 250-252.
  40. Gordo, I. and Dionisio, F. (2005). Nonequilibrium model for estimating parameters of deleterious mutations. Phys Rev E Stat Nonlin Soft Matter Phys 71(3 Pt 1): 031907.