TH
Toshiyuki Habu
  • Radiation Biology Center, Kyoto University, Japan
研究方向
  • Microbiology
个人信息

Education

Ph.D. in Molecular Biology, Medical School, Osaka University, 1998

Current position

Assistant Professor, Radiation Biology Center, Kyoto University (04/2002-present)

Publications

Peer-reviewed articles

  1. Kunoh, T. and Habu, T. (2014). Pcf1, a large subunit of CAF-1, required for maintenance of checkpoint kinase Cds1 activity. Springerplus 3: 30.
  2. Habu, T. and Matsumoto, T. (2013). p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs. Springerplus 2: 562.
  3. Hitomi, T.*, Habu, T.*, Kobayashi, H., Okuda, H., Harada, K. H., Osafune, K., Taura, D., Sone, M., Asaka, I., Ameku, T., Watanabe, A., Kasahara, T., Sudo, T., Shiota, F., Hashikata, H., Takagi, Y., Morito, D., Miyamoto, S., Nakao, K. and Koizumi, A. (2013). The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality. Biochem Biophys Res Commun 439(4): 419-426.
    *These authors contributed equally to this work
  4. Hitomi, T.*, Habu, T.*, Kobayashi, H., Okuda, H., Harada, K. H., Osafune, K., Taura, D., Sone, M., Asaka, I., Ameku, T., Watanabe, A., Kasahara, T., Sudo, T., Shiota, F., Hashikata, H., Takagi, Y., Morito, D., Miyamoto, S., Nakao, K. and Koizumi, A. (2013). Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients. Biochem Biophys Res Commun 438(1): 13-19.
    *These authors contributed equally to this work
  5. Horikoshi, Y., Habu, T. and Matsumoto, T. (2013). An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast. Cell Cycle 12(6): 961-971.
  6. Kobayashi, H., Yamazaki, S., Takashima, S., Liu, W., Okuda, H., Yan, J., Fujii, Y., Hitomi, T., Harada, K. H., Habu, T. and Koizumi, A. (2013). Ablation of Rnf213 retards progression of diabetes in the Akita mouse. Biochem Biophys Res Commun 432(3): 519-525.
  7. Iimori, M., Ozaki, K., Chikashige, Y., Habu, T., Hiraoka, Y., Maki, T., Hayashi, I., Obuse, C. and Matsumoto, T. (2012). A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules. Exp Cell Res 318(3): 262-275.
  8. Shimada, M., Kato, A., Habu, T. and Komatsu, K. (2011). Genistein, isoflavonoids in soybeans, prevents the formation of excess radiation-induced centrosomes via p21 up-regulation. Mutat Res 716(1-2): 27-32.
  9. Kobayashi, H., Abe, K., Matsuura, T., Ikeda, Y., Hitomi, T., Akechi, Y., Habu, T., Liu, W., Okuda, H. and Koizumi, A. (2011). Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement. Am J Hum Genet 89(1): 121-130.
  10. Hanafusa, T., Habu, T., Tomida, J., Ohashi, E., Murakumo, Y. and Ohmori, H. (2010). Overlapping in short motif sequences for binding to human REV7 and MAD2 proteins. Genes Cells.
  11. Shimada, M., Sagae, R., Kobayashi, J., Habu, T. and Komatsu, K. (2009). Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway. Cancer Res 69(5): 1768-1775.
  12. Kunoh, T., Habu, T. and Matsumoto, T. (2008). Involvement of fission yeast Clr6-HDAC in regulation of the checkpoint kinase Cds1. Nucleic Acids Res 36(10): 3311-3319.
  13. Xia, G., Luo, X., Habu, T., Rizo, J., Matsumoto, T. and Yu, H. (2004). Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J 23(15): 3133-3143.
  14. Habu, T., Wakabayashi, N., Yoshida, K., Yomogida, K., Nishimune, Y. and Morita, T. (2004). p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis. Carcinogenesis 25(6): 889-893.
  15. Habu, T., Kim, S. H., Weinstein, J. and Matsumoto, T. (2002). Identification of a MAD2-binding protein, CMT2, and its role in mitosis. EMBO J 21(23): 6419-6428.
  16. Wakabayashi, N., Kageyama, R., Habu, T., Doi, T., Morita, T., Nozaki, M., Yamamoto, M. and Nishimune, Y. (2000). A novel cis-acting element regulates HES-1 gene expression in P19 embryonal carcinoma cells treated with retinoic acid. J Biochem 128(6): 1087-1095.
  17. Moens, P. B., Tarsounas, M., Morita, T., Habu, T., Rottinghaus, S. T., Freire, R., Jackson, S. P., Barlow, C. and Wynshaw-Boris, A. (1999). The association of ATR protein with mouse meiotic chromosome cores. Chromosoma 108(2): 95-102.
  18. Tanaka, H., Yoshimura, Y., Nozaki, M., Yomogida, K., Tsuchida, J., Tosaka, Y., Habu, T., Nakanishi, T., Okada, M., Nojima, H. and Nishimune, Y. (1999). Identification and characterization of a haploid germ cell-specific nuclear protein kinase (Haspin) in spermatid nuclei and its effects on somatic cells. J Biol Chem 274(24): 17049-17057.
  19. Yoshida, K., Kondoh, G., Matsuda, Y., Habu, T., Nishimune, Y. and Morita, T. (1998). The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Mol Cell 1(5): 707-718.
  20. Yamamoto, A., Taki, T., Yagi, H., Habu, T., Yoshida, K., Yoshimura, Y., Yamamoto, K., Matsushiro, A., Nishimune, Y. and Morita, T. (1996). Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol Gen Genet 251(1): 1-12.
  21. Matsuda, Y., Habu, T., Hori, T. and Morita, T. (1996). Chromosome mapping of the mouse homologue of DMC1, the yeast meiosis-specific homologous recombination gene. Chromosome Res 4(3): 249-250.
  22. Habu, T., Taki, T., West, A., Nishimune, Y. and Morita, T. (1996). The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. Nucleic Acids Res 24(3): 470-477.
  23. Yagi, H., Kato, T., Nagata, T., Habu, T., Nozaki, M., Matsushiro, A., Nishimune, Y. and Morita, T. (1995). Regulation of the mouse histone H2A.X gene promoter by the transcription factor E2F and CCAAT binding protein. J Biol Chem 270(32): 18759-18765.