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Fathia Mami-Chouaib
  • INSERM (Institut National de la Santé et de la Recherche Médicale) U753, Team 1: Tumor Antigens and T-cell Reactivity, Gustave Roussy (Institut de Cancérologie Gustave Roussy), France
研究方向
  • Cancer biology
个人信息

Education

Ph.D. in Immunology, Pasteur Institute, University Pierre and Marie Curie, Paris, France,1984

Current position

Research Director at INSERM, Gustave Roussy Institute, Villejuif, France
Her research focuses on Tumor Immunology in lung cancer.

Publications (since 2005)

  1. Akalay, I., Janji, B., Hasmim, M., Noman, M. Z., Thiery, J. P., Mami-Chouaib, F. and Chouaib, S. (2013). EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction. Autophagy 9(7).
  2. Akalay, I., Janji, B., Hasmim, M., Noman, M. Z., Andre, F., De Cremoux, P., Bertheau, P., Badoual, C., Vielh, P., Larsen, A. K., Sabbah, M., Tan, T. Z., Keira, J. H., Hung, N. T., Thiery, J. P., Mami-Chouaib, F. and Chouaib, S. (2013). Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis. Cancer Res 73(8): 2418-2427.
  3. Franciszkiewicz, K., Le Floc'h, A., Boutet, M., Vergnon, I., Schmitt, A. and Mami-Chouaib, F. (2013). CD103 or LFA-1 engagement at the immune synapse between cytotoxic T cells and tumor cells promotes maturation and regulates T-cell effector functions. Cancer Res 73(2): 617-628.
  4. Noman, M. Z., Janji, B., Berchem, G., Mami-Chouaib, F. and Chouaib, S. (2012). Hypoxia-induced autophagy: a new player in cancer immunotherapy? Autophagy 8(4): 704-706.
  5. Noman, M. Z., Buart, S., Romero, P., Ketari, S., Janji, B., Mari, B., Mami-Chouaib, F. and Chouaib, S. (2012). Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells. Cancer Res 72(18): 4629-4641.
  6. Salmon, H., Franciszkiewicz, K., Damotte, D., Dieu-Nosjean, M. C., Validire, P., Trautmann, A., Mami-Chouaib, F. and Donnadieu, E. (2012). Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. J Clin Invest 122(3): 899-910.
  7. Durgeau, A., El Hage, F., Vergnon, I., Validire, P., de Montpreville, V., Besse, B., Soria, J. C., van Hall, T. and Mami-Chouaib, F. (2011). Different expression levels of the TAP peptide transporter lead to recognition of different antigenic peptides by tumor-specific CTL. J Immunol 187(11): 5532-5539.
  8. Hasmim, M., Noman, M. Z., Lauriol, J., Benlalam, H., Mallavialle, A., Rosselli, F., Mami-Chouaib, F., Alcaide-Loridan, C. and Chouaib, S. (2011). Hypoxia-dependent inhibition of tumor cell susceptibility to CTL-mediated lysis involves NANOG induction in target cells. J Immunol 187(8): 4031-4039.
  9. Noman, M. Z., Janji, B., Kaminska, B., Van Moer, K., Pierson, S., Przanowski, P., Buart, S., Berchem, G., Romero, P., Mami-Chouaib, F. and Chouaib, S. (2011). Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression. Cancer Res 71(18): 5976-5986.
  10. Tabbekh, M., Franciszkiewicz, K., Haouas, H., Lecluse, Y., Benihoud, K., Raman, C. and Mami-Chouaib, F. (2011). Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice. J Immunol 187(1): 102-109.
  11. Le Floc'h, A., Jalil, A., Franciszkiewicz, K., Validire, P., Vergnon, I. and Mami-Chouaib, F. (2011). Minimal engagement of CD103 on cytotoxic T lymphocytes with an E-cadherin-Fc molecule triggers lytic granule polarization via a phospholipase Cγ-dependent pathway. Cancer Res 71(2): 328-338.
  12. Cherfils-Vicini, J., Platonova, S., Gillard, M., Laurans, L., Validire, P., Caliandro, R., Magdeleinat, P., Mami-Chouaib, F., Dieu-Nosjean, M. C., Fridman, W. H., Damotte, D., Sautes-Fridman, C. and Cremer, I. (2010). Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest 120(4): 1285-1297.
  13. Franciszkiewicz, K., Le Floc'h, A., Jalil, A., Vigant, F., Robert, T., Vergnon, I., Mackiewicz, A., Benihoud, K., Validire, P., Chouaib, S., Combadiere, C. and Mami-Chouaib, F. (2009). Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res 69(15): 6249-6255.
  14. Benlalam, H., Jalil, A., Hasmim, M., Pang, B., Tamouza, R., Mitterrand, M., Godet, Y., Lamerant, N., Robert, C., Avril, M. F., Neefjes, J., Tursz, T., Mami-Chouaib, F., Kieda, C. and Chouaib, S. (2009). Gap junction communication between autologous endothelial and tumor cells induce cross-recognition and elimination by specific CTL. J Immunol 182(5): 2654-2664.
  15. Noman, M. Z., Buart, S., Van Pelt, J., Richon, C., Hasmim, M., Leleu, N., Suchorska, W. M., Jalil, A., Lecluse, Y., El Hage, F., Giuliani, M., Pichon, C., Azzarone, B., Mazure, N., Romero, P., Mami-Chouaib, F. and Chouaib, S. (2009). The cooperative induction of hypoxia-inducible factor-1α and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis. J Immunol 182(6): 3510-3521.
  16. Abouzahr-Rifai, S., Hasmim, M., Boukerche, H., Hamelin, J., Janji, B., Jalil, A., Kieda, C., Mami-Chouaib, F., Bertoglio, J. and Chouaib, S. (2008). Resistance of tumor cells to cytolytic T lymphocytes involves Rho-GTPases and focal adhesion kinase activation. J Biol Chem 283(46): 31665-31672.
  17. El Hage, F., Stroobant, V., Vergnon, I., Baurain, J. F., Echchakir, H., Lazar, V., Chouaib, S., Coulie, P. G. and Mami-Chouaib, F. (2008). Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathway. Proc Natl Acad Sci U S A 105(29): 10119-10124.
  18. Le Maux Chansac, B., Misse, D., Richon, C., Vergnon, I., Kubin, M., Soria, J. C., Moretta, A., Chouaib, S. and Mami-Chouaib, F. (2008). Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway. Int Immunol 20(7): 801-810.
  19. Friedlein, G., El Hage, F., Vergnon, I., Richon, C., Saulnier, P., Lecluse, Y., Caignard, A., Boumsell, L., Bismuth, G., Chouaib, S. and Mami-Chouaib, F. (2007). Human CD5 protects circulating tumor antigen-specific CTL from tumor-mediated activation-induced cell death. J Immunol 178(11): 6821-6827.
  20. Le Floc'h, A., Jalil, A., Vergnon, I., Le Maux Chansac, B., Lazar, V., Bismuth, G., Chouaib, S. and Mami-Chouaib, F. (2007). αEβ7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. J Exp Med 204(3): 559-570.
  21. Abouzahr, S., Bismuth, G., Gaudin, C., Caroll, O., Van Endert, P., Jalil, A., Dausset, J., Vergnon, I., Richon, C., Kauffmann, A., Galon, J., Raposo, G., Mami-Chouaib, F. and Chouaib, S. (2006). Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure. Proc Natl Acad Sci U S A 103(5): 1428-1433.
  22. El Hage, F., Vergnon, I., Grunenwald, D., Soria, J. C., Chouaib, S. and Mami-Chouaib, F. (2005). Generation of diverse mutated tumor antigen-specific cytotoxic T lymphocytes in a lung cancer patient with long survival. Oncol Rep 14(3): 763-769.
  23. Le Maux Chansac, B., Moretta, A., Vergnon, I., Opolon, P., Lecluse, Y., Grunenwald, D., Kubin, M., Soria, J. C., Chouaib, S. and Mami-Chouaib, F. (2005). NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors. J Immunol 175(9): 5790-5798.
  24. Thiery, J., Abouzahr, S., Dorothee, G., Jalil, A., Richon, C., Vergnon, I., Mami-Chouaib, F. and Chouaib, S. (2005). p53 potentiation of tumor cell susceptibility to CTL involves Fas and mitochondrial pathways. J Immunol 174(2): 871-878.
  25. Dorothee, G., Vergnon, I., El Hage, F., Le Maux Chansac, B., Ferrand, V., Lecluse, Y., Opolon, P., Chouaib, S., Bismuth, G. and Mami-Chouaib, F. (2005). In situ sensory adaptation of tumor-infiltrating T lymphocytes to peptide-MHC levels elicits strong antitumor reactivity. J Immunol 174(11): 6888-6897.

Reviews

  1. Tabbekh, M., Mokrani-Hammani, M., Bismuth, G. and Mami-Chouaib, F. (2013). T-cell modulatory properties of CD5 and its role in antitumor immune responses. Oncoimmunology 2(1): e22841.
  2. El Hage, F., Durgeau, A. and Mami-Chouaib, F. (2013). TAP expression level in tumor cells defines the nature and processing of MHC class I peptides for recognition by tumor-specific cytotoxic T lymphocytes. Ann N Y Acad Sci 1283: 75-80.
  3. Franciszkiewicz, K., Boissonnas, A., Boutet, M., Combadiere, C. and Mami-Chouaib, F. (2012). Role of chemokines and chemokine receptors in shaping the effector phase of the antitumor immune response. Cancer Res 72(24): 6325-6332.
  4. Noman, M. Z., Janji, B., Berchem, G., Mami-Chouaib, F. and Chouaib, S. (2012). Hypoxia-induced autophagy: a new player in cancer immunotherapy? Autophagy 8(4): 704-706.
  5. Chouaib, S., Kieda, C., Benlalam, H., Noman, M. Z., Mami-Chouaib, F. and Ruegg, C. (2010). Endothelial cells as key determinants of the tumor microenvironment: interaction with tumor cells, extracellular matrix and immune killer cells. Crit Rev Immunol 30(6): 529-545.
  6. Chouaib, S., Meslin, F., Thiery, J. and Mami-Chouaib, F. (2009). Tumor resistance to specific lysis: a major hurdle for successful immunotherapy of cancer. Clin Immunol 130(1): 34-40.
  7. El Hage, F., Abouzahr-Rifai, S., Meslin, F., Mami-Chouaib, F. and Chouaib, S. (2008). [Immune response and cancer]. Bull Cancer 95(1): 57-67.
  8. Chouaib, S., El Hage, F., Benlalam, H. and Mami-Chouaib, F. (2006). [Immunotherapy of cancer: promise and reality]. Med Sci (Paris) 22(8-9): 755-759.

Books

  1. Chouaib, S., Caignard, A. and Mami-Chouaib, F. (2003). L’échappement tumoral à l’immunosurveillance. Immunologie des Cancers. Editions Flammarion Médecine-Sciences.
  2. Echchakir. H., Chouaib, S. and Mami-Chouaib, F. (2007). Les antigènes associés aux tumeurs humaines. Hématologie. 7: 260-271.
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