RS
Ren Sun
  • Department of Molecular and Medical Pharmacology, University of California, USA
研究方向
  • Microbiology
个人信息

Education

Ph.D. in Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 1993

Current position

Professor of Molecular and Medical Pharmacology, University of California, Los Angeles, USA
Professor of Bioengineering, University of California, Los Angeles, USA

Publications

Selected peer-reviewed publications among a total of 130

  1. Qi, H., Olson, C. A., Wu, N. C., Ke, R., Loverdo, C., Chu, V., Truong, S., Remenyi, R., Chen, Z., Du, Y., Su, S. Y., Al-Mawsawi, L. Q., Wu, T. T., Chen, S. H., Lin, C. Y., Zhong, W., Lloyd-Smith, J. O. and Sun, R. (2014). A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity. PLoS Pathog 10(4): e1004064.
  2. Wu, N. C., Young, A. P., Al-Mawsawi, L. Q., Olson, C. A., Feng, J., Qi, H., Luan, H. H., Li, X., Wu, T. T. and Sun, R. (2014). High-throughput identification of loss-of-function mutations for anti-interferon activity in the influenza A virus NS segment. J Virol 88(17): 10157-10164.
  3. Olson, C. A., Nie, J., Diep, J., Al-Shyoukh, I., Takahashi, T. T., Al-Mawsawi, L. Q., Bolin, J. M., Elwell, A. L., Swanson, S., Stewart, R., Thomson, J. A., Soh, H. T., Roberts, R. W. and Sun, R. (2012). Single-round, multiplexed antibody mimetic design through mRNA display. Angew Chem Int Ed Engl 51(50): 12449-12453.
  4. Olson, C. A., Wu, N. C. and Sun, R. (2014). A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain. Curr Biol 24(22): 2643-2651.
  5. Li, X., Feng, J. and Sun, R. (2011). Oxidative stress induces reactivation of Kaposi's sarcoma-associated herpesvirus and death of primary effusion lymphoma cells. J Virol 85(2): 715-724.
  6. Leang, R. S., Wu, T. T., Hwang, S., Liang, L. T., Tong, L., Truong, J. T. and Sun, R. (2011). The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. PLoS Pathog 7(10): e1002292.
  7. Lee, S., Salwinski, L., Zhang, C., Chu, D., Sampankanpanich, C., Reyes, N. A., Vangeloff, A., Xing, F., Li, X., Wu, T. T., Sahasrabudhe, S., Deng, H., Lacount, D. J. and Sun, R. (2011). An integrated approach to elucidate the intra-viral and viral-cellular protein interaction networks of a gamma-herpesvirus. PLoS Pathog 7(10): e1002297.
  8. Olson, C. A., Adams, J. D., Takahashi, T. T., Qi, H., Howell, S. M., Wu, T. T., Roberts, R. W., Sun, R. and Soh, H. T. (2011). Rapid mRNA-display selection of an IL-6 inhibitor using continuous-flow magnetic separation. Angew Chem Int Ed Engl 50(36): 8295-8298.
  9. Yu, F., Al-Shyoukh, I., Feng, J., Li, X., Liao, C. W., Ho, C. M., Shamma, J. S. and Sun, R. (2011). Control of Kaposi's sarcoma-associated herpesvirus reactivation induced by multiple signals. PLoS One 6(6): e20998.
  10. Al-Shyoukh, I., Yu, F., Feng, J., Yan, K., Dubinett, S., Ho, C. M., Shamma, J. S. and Sun, R. (2011). Systematic quantitative characterization of cellular responses induced by multiple signals. BMC Syst Biol 5: 88.
  11. Hwang, S., Kim, K. S., Flano, E., Wu, T. T., Tong, L. M., Park, A. N., Song, M. J., Sanchez, D. J., O'Connell, R. M., Cheng, G. and Sun, R. (2009). Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response. Cell Host Microbe 5(2): 166-178.
  12. Liao, H. I., Olson, C. A., Hwang, S., Deng, H., Wong, E., Baric, R. S., Roberts, R. W. and Sun, R. (2009). mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein. J Biol Chem 284(26): 17512-17520.
  13. Sun, C. P., Usui, T., Yu, F., Al-Shyoukh, I., Shamma, J., Sun, R. and Ho, C. M. (2009). Integrative systems control approach for reactivating Kaposi's sarcoma-associated herpesvirus (KSHV) with combinatory drugs. Integr Biol (Camb) 1(1): 123-130.
  14. Arumugaswami, V., Sitapara, R., Hwang, S., Song, M. J., Ho, T. N., Su, N. Q., Sue, E. Y., Kanagavel, V., Xing, F., Zhang, X., Zhao, M., Deng, H., Wu, T. T., Kanagavel, S., Zhang, L., Dandekar, S., Papp, J. and Sun, R. (2009). High-resolution functional profiling of a gammaherpesvirus RTA locus in the context of the viral genome. J Virol 83(4): 1811-1822.
  15. Arumugaswami, V., Remenyi, R., Kanagavel, V., Sue, E. Y., Ngoc Ho, T., Liu, C., Fontanes, V., Dasgupta, A. and Sun, R. (2008). High-resolution functional profiling of hepatitis C virus genome. PLoS Pathog 4(10): e1000182.
  16. Wong, P. K., Yu, F., Shahangian, A., Cheng, G., Sun, R. and Ho, C. M. (2008). Closed-loop control: A generic method for optimizing drug cocktails. Proc National Academy of Science USA.
  17. Yu, F., Harada, J. N., Brown, H. J., Deng, H., Song, M. J., Wu, T. T., Kato-Stankiewicz, J., Nelson, C. G., Vieira, J., Tamanoi, F., Chanda, S. K. and Sun, R. (2007). Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus. PLoS Pathog 3(3): e44.
  18. Song, M. J., Hwang, S., Wong, W. H., Wu, T. T., Lee, S., Liao, H. I. and Sun, R. (2005). Identification of viral genes essential for replication of murine gamma-herpesvirus 68 using signature-tagged mutagenesis. Proc Natl Acad Sci U S A 102(10): 3805-3810.
  19. Rickabaugh, T. M., Brown, H. J., Martinez-Guzman, D., Wu, T. T., Tong, L., Yu, F., Cole, S. and Sun, R. (2004). Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection. J Virol 78(17): 9215-9223.
  20. Wu, T. T., Usherwood, E. J., Stewart, J. P., Nash, A. A. and Sun, R. (2000). Rta of murine gammaherpesvirus 68 reactivates the complete lytic cycle from latency. J Virol 74(8): 3659-3667.