BK
Byung S. Kim
  • Department of Brain Science, Ajou University School of Medicine, Korea
研究方向
  • Immunology
个人信息

Education

Ph.D. in Microbiology and Immunology, University of Illinois Medical Center, 1973

Current position

Professor Emeritus, Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL

Publications (since 2005)

  1. Jin, Y. H., Kang, H. S., Hou, W., Meng, L. and Kim, B. S. (2015). The level of viral infection of antigen-presenting cells correlates with the level of development of Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Virol 89(3): 1867-1878.
  2. Hou, W., Jin, Y. H., Kang, H. S. and Kim, B. S. (2014). Interleukin-6 (IL-6) and IL-17 synergistically promote viral persistence by inhibiting cellular apoptosis and cytotoxic T cell function. J Virol 88(15): 8479-8489.
  3. Kaneyama, T., Tomiki, H., Tsugane, S., Inaba, Y., Ichikawa, M., Akiba, H., Yagita, H., Kim, B. S. and Koh, C. S. (2014). The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease. Int Immunol 26(7): 369-381.
  4. Takizawa, S., Kaneyama, T., Tsugane, S., Takeichi, N., Yanagisawa, S., Ichikawa, M., Yagita, H., Kim, B. S. and Koh, C. S. (2014). Role of the Programmed Death-1 (PD-1) pathway in regulation of Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neuroimmunol 274(1-2): 78-85.
  5. Tomiki, H., Kaneyama, T., Kobayashi, K., Inaba, Y., Ichikawa, M., Yagita, H., Kim, B. S. and Koh, C. S. (2014). Therapeutic effect of anti-alphav integrin mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neuroimmunol 268(1-2): 25-34.
  6. Jin, Y. H., Hou, W., Kang, H. S., Koh, C. S. and Kim, B. S. (2013). The role of interleukin-6 in the expression of PD-1 and PDL-1 on central nervous system cells following infection with Theiler's murine encephalomyelitis virus. J Virol 87(21): 11538-11551.
  7. Jin, Y. H., Kim, S. J., So, E. Y., Meng, L., Colonna, M. and Kim, B. S. (2012). Melanoma differentiation-associated gene 5 is critical for protection against Theiler's virus-induced demyelinating disease. J Virol 86(3): 1531-1543.
  8. Kim, B. S., Jin, Y. H., Meng, L., Hou, W., Kang, H. S., Park, H. S. and Koh, C. S. (2012). IL-1 signal affects both protection and pathogenesis of virus-induced chronic CNS demyelinating disease. J Neuroinflammation 9(1): 217.
  9. Myoung, J., Kang, H. S., Hou, W., Meng, L., Dal Canto, M. C. and Kim, B. S. (2012). Epitope-specific CD8+ T cells play a differential pathogenic role in the development of a viral disease model for multiple sclerosis. J Virol 86(24): 13717-13728.
  10. Tsugane, S., Takizawa, S., Kaneyama, T., Ichikawa, M., Yagita, H., Kim, B. S. and Koh, C. S. (2012). Therapeutic effects of anti-Delta1 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neuroimmunol 252(1-2): 66-74.
  11. Jin, Y. H., Kang, H. S., Mohindru, M. and Kim, B. S. (2011). Preferential induction of protective T cell responses to Theiler's virus in resistant (C57BL/6 x SJL)F1 mice. J Virol 85(6): 3033-3040.
  12. Jin, Y. H., Kaneyama, T., Kang, M. H., Kang, H. S., Koh, C. S. and Kim, B. S. (2011). TLR3 signaling is either protective or pathogenic for the development of Theiler's virus-induced demyelinating disease depending on the time of viral infection. J Neuroinflammation 8: 178.
  13. Richards, M. H., Getts, M. T., Podojil, J. R., Jin, Y. H., Kim, B. S. and Miller, S. D. (2011). Virus expanded regulatory T cells control disease severity in the Theiler's virus mouse model of MS. J Autoimmun 36(2): 142-154.
  14. Jin, Y. H., Hou, W., Kim, S. J., Fuller, A. C., Kang, B., Goings, G., Miller, S. D. and Kim, B. S. (2010). Type I interferon signals control Theiler's virus infection site, cellular infiltration and T cell stimulation in the CNS. J Neuroimmunol 226(1-2): 27-37.
  15. Kang, H. S. and Kim, B. S. (2010). Predominant clonal accumulation of CD8+ T cells with moderate avidity in the central nervous systems of Theiler's virus-infected C57BL/6 mice. J Virol 84(6): 2774-2786.
  16. Takeichi, N., Yanagisawa, S., Kaneyama, T., Yagita, H., Jin, Y. H., Kim, B. S. and Koh, C. S. (2010). Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease. Int Immunol 22(9): 729-738.
  17. Yanagisawa, S., Takeichi, N., Kaneyama, T., Yagita, H., Taniguchi, S., Kim, B. S. and Koh, C. S. (2010). Effects of anti-CD70 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease. Brain Res 1317: 236-245.
  18. Hou, W., Kang, H. S. and Kim, B. S. (2009). Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. J Exp Med 206(2): 313-328.
  19. Jin, Y. H., Kang, B. and Kim, B. S. (2009). Theiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J mice. J Virol 83(21): 10981-10992.
  20. So, E. Y. and Kim, B. S. (2009). Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production. Glia 57(11): 1216-1226.
  21. Kang, M. H., So, E. Y., Park, H. and Kim, B. S. (2008). Replication of Theiler's virus requires NF-kappa B-activation: higher viral replication and spreading in astrocytes from susceptible mice. Glia 56(9): 942-953.
  22. Myoung, J., Bahk, Y. Y., Kang, H. S., Dal Canto, M. C. and Kim, B. S. (2008). Anticapsid immunity level, not viral persistence level, correlates with the progression of Theiler's virus-induced demyelinating disease in viral P1-transgenic mice. J Virol 82(11): 5606-5617.
  23. Hou, W., So, E. Y. and Kim, B. S. (2007). Role of dendritic cells in differential susceptibility to viral demyelinating disease. PLoS Pathog 3(8): e124.
  24. Jin, Y. H., Mohindru, M., Kang, M. H., Fuller, A. C., Kang, B., Gallo, D. and Kim, B. S. (2007). Differential virus replication, cytokine production, and antigen-presenting function by microglia from susceptible and resistant mice infected with Theiler's virus. J Virol 81(21): 11690-11702.
  25. Kang, B. S., Yahikozawa, H., Koh, C. S. and Kim, B. S. (2007). Oral administration of live virus protects susceptible mice from developing Theiler's virus-induced demyelinating disease. Virology 366(1): 185-196.
  26. Getts, M. T., Kim, B. S. and Miller, S. D. (2007). Differential outcome of tolerance induction in naive versus activated Theiler's virus epitope-specific CD8+ cytotoxic T cells. J Virol 81(12): 6584-6593.
  27. Fuller, A., Yahikozawa, H., So, E. Y., Dal Canto, M., Koh, C. S., Welsh, C. J. and Kim, B. S. (2007). Castration of male C57L/J mice increases susceptibility and estrogen treatment restores resistance to Theiler's virus-induced demyelinating disease. J Neurosci Res 85(4): 871-881.
  28. Myoung, J., Hou, W., Kang, B., Lyman, M. A., Kang, J. A. and Kim, B. S. (2007). The immunodominant CD8+ T cell epitope region of Theiler's virus in resistant C57BL/6 mice is critical for anti-viral immune responses, viral persistence, and binding to the host cells. Virology 360(1): 159-171.
  29. Mohindru, M., Kang, B. and Kim, B. S. (2006). Initial capsid-specific CD4(+) T cell responses protect against Theiler's murine encephalomyelitisvirus-induced demyelinating disease. Eur J Immunol 36(8): 2106-2115.
  30. So, E. Y., Kang, M. H. and Kim, B. S. (2006). Induction of chemokine and cytokine genes in astrocytes following infection with Theiler's murine encephalomyelitis virus is mediated by the Toll-like receptor 3. Glia 53(8): 858-867.
  31. Kang, H. K., Chung, Y. J., Park, C. U., Jang, Y. S. and Kim, B. S. (2006). Induction of autoimmunity by immunization with hapten-modified hen egg lysozyme in hen egg lysozyme-transgenic mice. Immunology 117(3): 368-378.
  32. Kim, B. S. (2005). Theiler’s murine encephalomyelitis virus. Interview. Mol Asp Immunobiol 16:10-11.
  33. Fuller, A. C., Kang, B., Kang, H. K., Yahikozowa, H., Dal Canto, M. C. and Kim, B. S. (2005). Gender bias in Theiler's virus-induced demyelinating disease correlates with the level of antiviral immune responses. J Immunol 175(6): 3955-3963.
  34. Kim, B. S., Mohindru, M., Kang, B., Kang, H. S. and Palma, J. P. (2005). Effects of the major histocompatibility complex loci and T-cell receptor beta-chain repertoire on Theiler's virus-induced demyelinating disease. J Neurosci Res 81(6): 846-856.
  35. Kang, B. S., Palma, J. P., Lyman, M. A., Dal Canto, M. and Kim, B. S. (2005). Antibody response is required for protection from Theiler's virus-induced encephalitis in C57BL/6 mice in the absence of CD8+ T cells. Virology 340(1): 84-94.
  36. Kang, B., Kang, H. K. and Kim, B. S. (2005). Identification of capsid epitopes of Theiler's virus recognized by CNS-infiltrating CD4+ T cells from virus-infected C57BL/6 mice. Virus Res 108(1-2): 57-61.
  37. Kim, B. S., Palma, J. P., Kwon, D. and Fuller, A. C. (2005). Innate immune response induced by Theiler's murine encephalomyelitis virus infection. Immunol Res 31(1): 1-12.    
  38. Simmons, W. J., Koneru, M., Mohindru, M., Thomas, R., Cutro, S., Singh, P., Dekruyff, R. H., Inghirami, G., Coyle, A. J., Kim, B. S. and Ponzio, N. M. (2005). Tim-3+ T-bet+ tumor-specific Th1 cells colocalize with and inhibit development and growth of murine neoplasms. J Immunol 174(3): 1405-1415.