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Rosa María del Angel

Education

Ph.D. in Molecular Biology, Department of Genetics and Molecular Biology, CINVESTAV, México, 1991

Current Position

Professor in Virology, Department of Infectomics and Molecular Pathogenesis, CINVESTAV, México

Publications (since 2005)

  1. Vega-Almeida, T. O., Salas-Benito, M., De Nova-Ocampo, M. A., Del Angel, R. M. and Salas-Benito, J. S. (2013). Surface proteins of C6/36 cells involved in dengue virus 4 binding and entry. Arch Virol 158(6): 1189-1207.
  2. Soto-Acosta, R., Mosso, C., Cervantes-Salazar, M., Puerta-Guardo, H., Medina, F., Favari, L., Ludert, J. E. and del Angel, R. M. (2013). The increase in cholesterol levels at early stages after dengue virus infection correlates with an augment in LDL particle uptake and HMG-CoA reductase activity. Virology 442(2): 132-147.
  3. Puerta-Guardo, H., Raya-Sandino, A., Gonzalez-Mariscal, L., Rosales, V. H., Ayala-Davila, J., Chavez-Mungia, B., Martinez-Fong, D., Medina, F., Ludert, J. E. and del Angel, R. M. (2013). The cytokine response of U937-derived macrophages infected through antibody-dependent enhancement of dengue virus disrupts cell apical-junction complexes and increases vascular permeability. J Virol 87(13): 7486-7501.
  4. Juarez-Martinez, A. B., Vega-Almeida, T. O., Salas-Benito, M., Garcia-Espitia, M., De Nova-Ocampo, M., Del Angel, R. M. and Salas-Benito, J. S. (2013). Detection and sequencing of defective viral genomes in C6/36 cells persistently infected with dengue virus 2. Arch Virol 158(3): 583-599.
  5. De La Cruz Hernandez, S. I., Flores-Aguilar, H., Gonzalez-Mateos, S., Lopez-Martinez, I., Ortiz-Navarrete, V., Ludert, J. E. and Del Angel, R. M. (2013). Viral load in patients infected with dengue is modulated by the presence of anti-dengue IgM antibodies. J Clin Virol 58(1): 258-261.
  6. del Angel, R. M. and Reyes-del Valle, J. (2013). Dengue vaccines: strongly sought but not a reality just yet. PLoS Pathog 9(10): e1003551.
  7. de la Cruz-Hernandez, S. I., Ortiz-Navarrete, V., Ludert, J. E., del Angel, R. M. (2013). Dengue specific IgM seropositivity correlates with severe clinical outcome. J Clin Virol. doi:pii: S1386-6532(13)00417-4.
  8. de la Cruz-Hernandez, S. I., Flores-Aguilar, H., Gonzalez-Mateos, S., Lopez-Martinez, I., Alpuche-Aranda, C., Ludert, J. E. and del Angel, R. M. (2013). Determination of viremia and concentration of circulating nonstructural protein 1 in patients infected with dengue virus in Mexico. Am J Trop Med Hyg 88(3): 446-454.
  9. Puerta-Guardo, H., Medina, F., De la Cruz Hernandez, S. I., Rosales, V. H., Ludert, J. E. and del Angel, R. M. (2012). The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes. Antiviral Res 94(1): 57-61.
  10. de la Cruz Hernandez, S. I., Gonzalez Mateos, S., Flores Aguilar, H., Lopez Martinez, I., Alpuche Aranda, C., Ludert, J. E. and Del Angel, R. M. (2012). Evaluation of a novel commercial rapid test for dengue diagnosis based on specific IgA detection. Diagn Microbiol Infect Dis 72(2): 150-155.
  11. Alcaraz-Estrada, S. L., Yocupicio-Monroy, M. and del Angel, R. M. (2010). Insights into dengue virus genome replication. Future Virology 5(5): 575-592.
  12. Alcaraz-Estrada, S. L., Manzano, M. I., Del Angel, R. M., Levis, R. and Padmanabhan, R. (2010). Construction of a dengue virus type 4 reporter replicon and analysis of temperature-sensitive mutations in non-structural proteins 3 and 5. J Gen Virol 91(Pt 11): 2713-2718.
  13. Puerta-Guardo, H., Mosso, C., Medina, F., Liprandi, F., Ludert, J. E. and del Angel, R. M. (2010). Antibody-dependent enhancement of dengue virus infection in U937 cells requires cholesterol-rich membrane microdomains. J Gen Virol 91(Pt 2): 394-403.
  14. Ceballos-Olvera, I., Chavez-Salinas, S., Medina, F., Ludert, J. E. and del Angel, R. M. (2010). JNK phosphorylation, induced during dengue virus infection, is important for viral infection and requires the presence of cholesterol. Virology 396(1): 30-36.
  15. Agis-Juarez, R. A., Galvan, I., Medina, F., Daikoku, T., Padmanabhan, R., Ludert, J. E. and del Angel, R. M. (2009). Polypyrimidine tract-binding protein is relocated to the cytoplasm and is required during dengue virus infection in Vero cells. J Gen Virol 90(Pt 12): 2893-2901.
  16. Chavez-Salinas, S., Ceballos-Olvera, I., Reyes-del Valle, J., Medina, F. and del Angel, R. M. (2008). Heat shock effect upon dengue virus replication into U937 cells. Virus research 138(1): 111-118.
  17. Mosso, C., Galvan-Mendoza, I. J., Ludert, J. E. and del Angel, R. M. (2008). Endocytic pathway followed by dengue virus to infect the mosquito cell line C6/36 HT. Virology 378(1): 193-199.
  18. Ludert, J. E., Mosso, C., Ceballos-Olvera, I. and del Angel, R. M. (2008). Use of a commercial enzyme immunoassay to monitor dengue virus replication in cultured cells. Virol J 5: 51.
  19. Salas-Benito, J., Reyes-Del Valle, J., Salas-Benito, M., Ceballos-Olvera, I., Mosso, C. and del Angel, R. M. (2007). Evidence that the 45-kD glycoprotein, part of a putative dengue virus receptor complex in the mosquito cell line C6/36, is a heat-shock related protein. Am J Trop Med Hyg 77(2): 283-290.
  20. Gonzalez Duran, E., del Angel, R. M. and Salas Benito, J. S. (2007). In vitro interaction of poliovirus with cytoplasmic dynein. Intervirology 50(3): 214-218.
  21. Yocupicio-Monroy, M., Padmanabhan, R., Medina, F. and del Angel, R. M. (2007). Mosquito La protein binds to the 3' untranslated region of the positive and negative polarity dengue virus RNAs and relocates to the cytoplasm of infected cells. Virology 357(1): 29-40.
  22. del Angel, R. M. Chávez-Salinas, S., Ceballos-Olvera, I., Medina, F. Reyes-Del Valle, J. (2006). Proteínas celulares involucradas en la unión y entrada del virus del dengue. Revista Latinoamericana de Microbiología 48: 197-198.
  23. Reyes-Del Valle, J., Chavez-Salinas, S., Medina, F. and Del Angel, R. M. (2005). Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells. J Virol 79(8): 4557-4567.
Protocols by Rosa María del Angel
  1. Assay to Evaluate Vascular Permeability Induction in Mice