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Ralph T. Böttcher


Ph.D. (Dr rer nat) in Molecular Embryology, German Cancer Research Center (DKFZ)/University of Heidelberg, Germany, 2004

Current position

Group Leader, Max Planck Institute of Biochemistry, Department of Molecular Medicine, Germany


  1. Böttcher, R. T. and Fassler, R. (2014). Membrane tension drives ligand-independent integrin signaling. EMBO J 33(21): 2439-2441.    
  2. Tseng, H. Y., Thorausch, N., Ziegler, T., Meves, A., Fassler, R. and Böttcher, R. T. (2014). Sorting nexin 31 binds multiple beta integrin cytoplasmic domains and regulates beta1 integrin surface levels and stability. J Mol Biol 426(18): 3180-3194.
  3. Rognoni, E., Widmaier, M., Jakobson, M., Ruppert, R., Ussar, S., Katsougkri, D., Böttcher, R. T., Lai-Cheong, J. E., Rifkin, D. B., McGrath, J. A. and Fassler, R. (2014). Kindlin-1 controls Wnt and TGF-beta availability to regulate cutaneous stem cell proliferation. Nat Med 20(4): 350-359.
  4. Zheng, J., Lu, Z., Kocabas, F., Böttcher, R. T., Costell, M., Kang, X., Liu, X., DeBerardinis, R. J., Wang, Q. and Chen, G. Q. (2014). Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow. Blood 123(7): 992-1001.    
  5. Montani, L., Buerki-Thurnherr, T., de Faria, J. P., Pereira, J. A., Dias, N. G., Fernandes, R., Gonçalves, A. F., Braun, A., Benninger, Y. and Böttcher, R. T. (2014). Profilin 1 is required for peripheral nervous system myelination. Development 141(7): 1553-1561.    
  6. Meves, A., Stremmel, C., Böttcher, R. T. and Fassler, R. (2013). beta1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis. J Invest Dermatol 133(12): 2722-2731.
  7. Legate, K. R., Montag, D., Böttcher, R. T., Takahashi, S. and Fassler, R. (2012). Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Igamma in vivo. J Cell Sci 125(Pt 23): 5636-5646.
  8. Kullmann, J. A., Neumeyer, A., Wickertsheim, I., Böttcher, R. T., Costell, M., Deitmer, J. W., Witke, W., Friauf, E. and Rust, M. B. (2012). Purkinje cell loss and motor coordination defects in profilin1 mutant mice. Neuroscience 223: 355-364.
  9. Miyajima, D., Hayata, T., Suzuki, T., Hemmi, H., Nakamoto, T., Notomi, T., Amagasa, T., Böttcher, R. T., Costell, M., Fassler, R., Ezura, Y. and Noda, M. (2012). Profilin1 regulates sternum development and endochondral bone formation. J Biol Chem 287(40): 33545-33553.
  10. Böttcher, R. T., Stremmel, C., Meves, A., Meyer, H., Widmaier, M., Tseng, H. Y. and Fassler, R. (2012). Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Nat Cell Biol 14(6): 584-592.
  11. Azimifar, S. B., Böttcher, R. T., Zanivan, S., Grashoff, C., Kruger, M., Legate, K. R., Mann, M. and Fassler, R. (2012). Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor. J Cell Sci 125(Pt 2): 435-448.
  12. Gorlich, A., Zimmermann, A. M., Schober, D., Böttcher, R. T., Sassoe-Pognetto, M., Friauf, E., Witke, W. and Rust, M. B. (2012). Preserved morphology and physiology of excitatory synapses in profilin1-deficient mice. PLoS ONE 7(1): e30068.
  13. Böttcher, R. T., Lange, A. and Fassler, R. (2009). How ILK and kindlins cooperate to orchestrate integrin signaling. Curr Opin Cell Biol 21(5): 670-675.
  14. Karaulanov, E., Böttcher, R. T., Stannek, P., Wu, W., Rau, M., Ogata, S., Cho, K. W. and Niehrs, C. (2009). Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos. PLoS ONE 4(5): e5742.
  15. Böttcher, R. T., Wiesner, S., Braun, A., Wimmer, R., Berna, A., Elad, N., Medalia, O., Pfeifer, A., Aszodi, A., Costell, M. and Fassler, R. (2009). Profilin 1 is required for abscission during late cytokinesis of chondrocytes. EMBO J 28(8): 1157-1169.
  16. Karaulanov, E. E.*, Böttcher, R. T.* and Niehrs, C. (2006). A role for fibronectin-leucine-rich transmembrane cell-surface proteins in homotypic cell adhesion. EMBO Rep 7(3): 283-290. (*Equal contribution)
  17. Böttcher, R. T. and Niehrs, C. (2005). Fibroblast growth factor signaling during early vertebrate development. Endocr Rev 26(1): 63-77. (cover)
  18. Böttcher, R. T., Pollet, N., Delius, H. and Niehrs, C. (2004). The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling. Nat Cell Biol 6(1): 38-44.
Protocols by Ralph T. Böttcher
  1. β1 Integrin Cell-surface Immunoprecipitation (Selective Immunoprecipitation)