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Elías   Barquero-Calvo

Elías Barquero-Calvo


Ph.D. in Science, Universidad de Costa Rica (UCR), 2013

Current position

Professor at the Veterinary School and the Postgraduate Veterinary Program of the National University of Costa Rica

Coordinator of the Bacteriology Laboratory at the Hospital Veterinary Program of the Veterinary School (since 2006)

Research focus: Elías Barquero-Calvo′s research concentrates in the understanding of the immunology and pathogenesis of brucellosis and other veterinary and human bacterial pathogens. His main studies are devoted to the mechanisms involved in early immune response and the role of neutrophils during brucellosis.


  1. Barquero-Calvo, E., Martirosyan, A., Ordonez-Rueda, D., Arce-Gorvel, V., Alfaro-Alarcon, A., Lepidi, H., Malissen, B., Malissen, M., Gorvel, J. P. and Moreno, E. (2013). Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus. PLoS Pathog 9(2): e1003167.
  2. Conde-Alvarez, R., Arce-Gorvel, V., Iriarte, M., Mancek-Keber, M., Barquero-Calvo, E., Palacios-Chaves, L., Chacon-Diaz, C., Chaves-Olarte, E., Martirosyan, A., von Bargen, K., Grillo, M. J., Jerala, R., Brandenburg, K., Llobet, E., Bengoechea, J. A., Moreno, E., Moriyon, I. and Gorvel, J. P. (2012). The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. PLoS Pathog 8(5): e1002675.
  3. Guzman-Verri, C., Gonzalez-Barrientos, R., Hernandez-Mora, G., Morales, J. A., Baquero-Calvo, E., Chaves-Olarte, E. and Moreno, E. (2012). Brucella ceti and brucellosis in cetaceans. Front Cell Infect Microbiol 2: 3.
  4. Lopez-Goni, I., Garcia-Yoldi, D., Marin, C. M., de Miguel, M. J., Barquero-Calvo, E., Guzman-Verri, C., Albert, D. and Garin-Bastuji, B. (2011). New Bruce-ladder multiplex PCR assay for the biovar typing of Brucella suis and the discrimination of Brucella suis and Brucella canis. Vet Microbiol 154(1-2): 152-155.
  5. Chacon-Diaz, C., Munoz-Rodriguez, M., Barquero-Calvo, E., Guzman-Verri, C., Chaves-Olarte, E., Grillo, M. J. and Moreno, E. (2011). The use of green fluorescent protein as a marker for Brucella vaccines. Vaccine 29(3): 577-582.
  6. Palacios-Chaves, L., Conde-Alvarez, R., Gil-Ramirez, Y., Zuniga-Ripa, A., Barquero-Calvo, E., Chacon-Diaz, C., Chaves-Olarte, E., Arce-Gorvel, V., Gorvel, J. P., Moreno, E., de Miguel, M. J., Grillo, M. J., Moriyon, I. and Iriarte, M. (2011). Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern. PLoS One 6(1): e16030.
  7. Gonzalez-Barrientos, R., Morales, J. A., Hernandez-Mora, G., Barquero-Calvo, E., Guzman-Verri, C., Chaves-Olarte, E. and Moreno, E. (2010). Pathology of striped dolphins (Stenella coeruleoalba) infected with Brucella ceti. J Comp Pathol 142(4): 347-352.
  8. Baldi, M., Morales, J. A., Hernandez, G., Jimenez, M., Alfaro, A. and Barquero-Calvo, E. (2010). Chromobacterium violaceum Infection in a free-ranging howler monkey in Costa Rica. J Wildl Dis 46(1): 306-310.
  9. Barquero-Calvo, E., Conde-Alvarez, R., Chacon-Diaz, C., Quesada-Lobo, L., Martirosyan, A., Guzman-Verri, C., Iriarte, M., Mancek-Keber, M., Jerala, R., Gorvel, J. P., Moriyon, I., Moreno, E. and Chaves-Olarte, E. (2009). The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens. PLoS One 4(6): e5893.
  10. Hernandez-Mora, G., Manire, C. A., Gonzalez-Barrientos, R., Barquero-Calvo, E., Guzman-Verri, C., Staggs, L., Thompson, R., Chaves-Olarte, E. and Moreno, E. (2009). Serological diagnosis of Brucella infections in odontocetes. Clin Vaccine Immunol 16(6): 906-915.
  11. Hernandez-Mora, G., Gonzalez-Barrientos, R., Morales, J. A., Chaves-Olarte, E., Guzman-Verri, C., Barquero-Calvo, E., De-Miguel, M. J., Marin, C. M., Blasco, J. M. and Moreno, E. (2008). Neurobrucellosis in stranded dolphins, Costa Rica. Emerg Infect Dis 14(9): 1430-1433.
  12. Manterola, L., Guzman-Verri, C., Chaves-Olarte, E., Barquero-Calvo, E., de Miguel, M. J., Moriyon, I., Grillo, M. J., Lopez-Goni, I. and Moreno, E. (2007). BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence. Infect Immun 75(10): 4867-4874.
  13. Barquero-Calvo, E., Chaves-Olarte, E., Weiss, D. S., Guzman-Verri, C., Chacon-Diaz, C., Rucavado, A., Moriyon, I. and Moreno, E. (2007). Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection. PLoS One 2(7): e631.
Protocols by Elías Barquero-Calvo
  1. Bacterial Counts in Spleen