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Hester J. Bootsma

Education

Ph.D., Faculty of Medicine, Utrecht University, Utrecht, The Netherlands, 1999

Current position

Senior scientist at Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands

Publications (since 2008)

International SCI journals

  1. Johnston, C., Caymaris, S., Zomer, A., Bootsma, H. J., Prudhomme, M., Granadel, C., Hermans, P. W., Polard, P., Martin, B. and Claverys, J. P. (2013). Natural Genetic Transformation Generates a Population of Merodiploids in Streptococcus pneumoniae. PLoS Genet 9(9): e1003819.
  2. de Vries, S. P., Eleveld, M. J., Hermans, P. W. and Bootsma, H. J. (2013). Characterization of the molecular interplay between Moraxella catarrhalis and human respiratory tract epithelial cells. PLoS One 8(8): e72193.
  3. de Vries, S. P., Burghout, P., Langereis, J. D., Zomer, A., Hermans, P. W. and Bootsma, H. J. (2013). Genetic requirements for Moraxella catarrhalis growth under iron-limiting conditions. Mol Microbiol 87(1): 14-29.
  4. Zomer, A., de Vries, S. P., Riesbeck, K., Meinke, A. L., Hermans, P. W. and Bootsma, H. J. (2012). Genome sequence of Moraxella catarrhalis RH4, an isolate of seroresistant lineage. J Bacteriol 194(24): 6969.
  5. van der Windt, D., Bootsma, H. J., Burghout, P., van der Gaast-de Jongh, C. E., Hermans, P. W. and van der Flier, M. (2012). Nonencapsulated Streptococcus pneumoniae resists extracellular human neutrophil elastase- and cathepsin G-mediated killing. FEMS Immunol Med Microbiol 66(3): 445-448.
  6. Zomer, A., Burghout, P., Bootsma, H. J., Hermans, P. W. and van Hijum, S. A. (2012). ESSENTIALS: software for rapid analysis of high throughput transposon insertion sequencing data. PLoS One 7(8): e43012.
  7. Langereis, J. D., Stol, K., Schweda, E. K., Twelkmeyer, B., Bootsma, H. J., de Vries, S. P., Burghout, P., Diavatopoulos, D. A. and Hermans, P. W. (2012). Modified lipooligosaccharide structure protects nontypeable Haemophilus influenzae from IgM-mediated complement killing in experimental otitis media. MBio 3(4): e00079-00012.
  8. Salter, S. J., Hinds, J., Gould, K. A., Lambertsen, L., Hanage, W. P., Antonio, M., Turner, P., Hermans, P. W., Bootsma, H. J., O'Brien, K. L. and Bentley, S. D. (2012). Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates. Microbiology 158(Pt 6): 1560-1569.
  9. Cron, L. E., Stol, K., Burghout, P., van Selm, S., Simonetti, E. R., Bootsma, H. J. and Hermans, P. W. (2011). Two DHH subfamily 1 proteins contribute to pneumococcal virulence and confer protection against pneumococcal disease. Infect Immun 79(9): 3697-3710.
  10. Lammers, A. J., de Porto, A. P., Florquin, S., de Boer, O. J., Bootsma, H. J., Hermans, P. W. and van der Poll, T. (2011). Enhanced vulnerability for Streptococcus pneumoniae sepsis during asplenia is determined by the bacterial capsule. Immunobiology 216(8): 863-870.
  11. Davie, J. J., Earl, J., de Vries, S. P., Ahmed, A., Hu, F. Z., Bootsma, H. J., Stol, K., Hermans, P. W., Wadowsky, R. M., Ehrlich, G. D., Hays, J. P. and Campagnari, A. A. (2011). Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates. BMC Genomics 12: 70.
  12. de Gouw, D., Diavatopoulos, D. A., Bootsma, H. J., Hermans, P. W. and Mooi, F. R. (2011). Pertussis: a matter of immune modulation. FEMS Microbiol Rev 35(3): 441-474.
  13. Schaar, V., de Vries, S. P., Perez Vidakovics, M. L., Bootsma, H. J., Larsson, L., Hermans, P. W., Bjartell, A., Morgelin, M. and Riesbeck, K. (2011). Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells. Cell Microbiol 13(3): 432-449.
  14. Molzen, T. E., Burghout, P., Bootsma, H. J., Brandt, C. T., van der Gaast-de Jongh, C. E., Eleveld, M. J., Verbeek, M. M., Frimodt-Moller, N., Ostergaard, C. and Hermans, P. W. (2011). Genome-wide identification of Streptococcus pneumoniae genes essential for bacterial replication during experimental meningitis. Infect Immun 79(1): 288-297.
  15. Caymaris, S., Bootsma, H. J., Martin, B., Hermans, P. W., Prudhomme, M. and Claverys, J. P. (2010). The global nutritional regulator CodY is an essential protein in the human pathogen Streptococcus pneumoniae. Mol Microbiol 78(2): 344-360.
  16. Burghout, P., Cron, L. E., Gradstedt, H., Quintero, B., Simonetti, E., Bijlsma, J. J., Bootsma, H. J. and Hermans, P. W. (2010). Carbonic anhydrase is essential for Streptococcus pneumoniae growth in environmental ambient air. J Bacteriol 192(15): 4054-4062.
  17. de Vries, S. P., van Hijum, S. A., Schueler, W., Riesbeck, K., Hays, J. P., Hermans, P. W. and Bootsma, H. J. (2010). Genome analysis of Moraxella catarrhalis strain BBH18: a human respiratory tract pathogen. J Bacteriol 192(14): 3574-3583.
  18. Leegaard, T. M.*, Bootsma, H. J.*, Caugant, D. A., Eleveld, M. J., Mannsaker, T., Froholm, L. O., Gaustad, P., Hoiby, E. A. and Hermans, P. W. (2010). Phenotypic and genomic characterization of pneumococcus-like streptococci isolated from HIV-seropositive patients. Microbiology 156(Pt 3): 838-848. * These authors contributed equally to this work
  19. Simoes, A. S., Sa-Leao, R., Eleveld, M. J., Tavares, D. A., Carrico, J. A., Bootsma, H. J. and Hermans, P. W. (2010). Highly penicillin-resistant multidrug-resistant pneumococcus-like strains colonizing children in Oeiras, Portugal: genomic characteristics and implications for surveillance. J Clin Microbiol 48(1): 238-246.
  20. Stol, K., van Selm, S., van den Berg, S., Bootsma, H. J., Blokx, W. A., Graamans, K., Tonnaer, E. L. and Hermans, P. W. (2009). Development of a non-invasive murine infection model for acute otitis media. Microbiology 155(Pt 12): 4135-4144.
  21. de Vries, S. P., Bootsma, H. J., Hays, J. P. and Hermans, P. W. (2009). Molecular aspects of Moraxella catarrhalis pathogenesis. Microbiol Mol Biol Rev 73(3): 389-406.
  22. Cron, L. E., Bootsma, H. J., Noske, N., Burghout, P., Hammerschmidt, S. and Hermans, P. W. (2009). Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization in a strain-specific manner. Microbiology 155(Pt 7): 2401-2410.
  23. Hendriksen, W. T., Bootsma, H. J., van Diepen, A., Estevao, S., Kuipers, O. P., de Groot, R. and Hermans, P. W. (2009). Strain-specific impact of PsaR of Streptococcus pneumoniae on global gene expression and virulence. Microbiology 155(Pt 5): 1569-1579.
  24. Milisavljevic, V., Tran, L. P., Batmalle, C. and Bootsma, H. J. (2008). Benzyl alcohol and ethanol can enhance the pathogenic potential of clinical Staphylococcus epidermidis strains. Am J Infect Control 36(8): 552-558.
  25. Hendriksen, W. T., Kloosterman, T. G., Bootsma, H. J., Estevao, S., de Groot, R., Kuipers, O. P. and Hermans, P. W. (2008). Site-specific contributions of glutamine-dependent regulator GlnR and GlnR-regulated genes to virulence of Streptococcus pneumoniae. Infect Immun 76(3): 1230-1238.
  26. Hendriksen, W. T., Bootsma, H. J., Estevao, S., Hoogenboezem, T., de Jong, A., de Groot, R., Kuipers, O. P. and Hermans, P. W. (2008). CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonization. J Bacteriol 190(2): 590-601.

International book chapters

Burghout. P., Bootsma, H. J., Hermans, P. W. (2007). Genome-wide screening for essential genes of Streptococcus pneumoniae: Current approaches and future opportunities. In: Molecular Biology of Streptococci. Hakenbeck, R. and Chhatwal, S. (eds). Horizon Bioscience, Norfolk, UK, pp 225-245.

Protocols by Hester J. Bootsma
  1. Adhesion of Moraxella catarrhalis to Respiratory Tract Epithelial Cells
  2. Analysis of Moraxella catarrhalis Outer Membrane Protein Profiles