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Philippe A. Parone

Education

Ph.D. in Biochemistry, University of Cambridge, Cambridge, UK, 2001

Current position

Postdoctoral Fellow in the Laboratory of Dr. Don W. Cleveland, Ludwig Institute, University of California, San Diego, USA

Publications

  1. Shelkovnikova, T. A., Peters, O. M., Deykin, A. V., Connor-Robson, N., Robinson, H., Ustyugov, A. A., Bachurin, S. O., Ermolkevich, T. G., Goldman, I. L., Sadchikova, E. R., Kovrazhkina, E. A., Skvortsova, V. I., Ling, S. C., Da Cruz, S., Parone, P. A., Buchman, V. L. and Ninkina, N. N. (2013). Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. J Biol Chem 288(35): 25266-25274.
  2. Arnold, E. S., Ling, S. C., Huelga, S. C., Lagier-Tourenne, C., Polymenidou, M., Ditsworth, D., Kordasiewicz, H. B., McAlonis-Downes, M., Platoshyn, O., Parone, P. A., Da Cruz, S., Clutario, K. M., Swing, D., Tessarollo, L., Marsala, M., Shaw, C. E., Yeo, G. W. and Cleveland, D. W. (2013). ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A 110(8): E736-745.
  3. Parone, P. A.*, Da Cruz, S.*, Han, J. S., McAlonis-Downes, M., Vetto, A. P., Lee, S. K., Tseng, E. and Cleveland, D. W. (2013). Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J Neurosci 33(11): 4657-4671. *Co-first authors
  4. Da Cruz, S.*, Parone, P. A.*, Lopes, V. S., Lillo, C., McAlonis-Downes, M., Lee, S. K., Vetto, A. P., Petrosyan, S., Marsala, M., Murphy, A. N., Williams, D. S., Spiegelman, B. M. and Cleveland, D. W. (2012). Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab 15(5): 778-786. *Co-first authors
  5. Da Cruz, S., De Marchi, U., Frieden, M., Parone, P. A., Martinou, J. C. and Demaurex, N. (2010). SLP-2 negatively modulates mitochondrial sodium-calcium exchange. Cell Calcium 47(1): 11-18.
  6. Da Cruz, S., Parone, P. A., Gonzalo, P., Bienvenut, W. V., Tondera, D., Jourdain, A., Quadroni, M. and Martinou, J. C. (2008). SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability. Biochim Biophys Acta 1783(5): 904-911.
  7. Parone, P. A., Da Cruz, S., Tondera, D., Mattenberger, Y., James, D. I., Maechler, P., Barja, F. and Martinou, J. C. (2008). Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One 3(9): e3257.
  8. Benard, G., Bellance, N., James, D., Parrone, P., Fernandez, H., Letellier, T. and Rossignol, R. (2007). Mitochondrial bioenergetics and structural network organization. Journal of cell science 120(5): 838-848.
  9. Lakkaraju, A. K., Luyet, P. P., Parone, P., Falguieres, T. and Strub, K. (2007). Inefficient targeting to the endoplasmic reticulum by the signal recognition particle elicits selective defects in post-ER membrane trafficking. Exp Cell Res 313(4): 834-847.
  10. Parone, P. A., James, D. I., Da Cruz, S., Mattenberger, Y., Donze, O., Barja, F. and Martinou, J. C. (2006). Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol Cell Biol 26(20): 7397-7408.
  11. Parone, P. A. and Martinou, J. C. (2006). Mitochondrial fission and apoptosis: an ongoing trial. Biochim Biophys Acta 1763(5-6): 522-530.
  12. Parone, P., Priault, M., James, D., Nothwehr, S. F. and Martinou, J. C. (2003). Apoptosis: bombarding the mitochondria. Essays Biochem 39: 41-51.
  13. Da Cruz, S., Parone, P. A. and Martinou, J. C. (2005). Building the mitochondrial proteome. Expert Rev Proteomics 2(4): 541-551.
  14. Da Cruz, S., Xenarios, I., Langridge, J., Vilbois, F., Parone, P. A. and Martinou, J. C. (2003). Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem 278(42): 41566-41571.
  15. James, D. I., Parone, P. A., Mattenberger, Y. and Martinou, J. C. (2003). hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem 278(38): 36373-36379.
  16. Arnoult, D., Parone, P., Martinou, J. C., Antonsson, B., Estaquier, J. and Ameisen, J. C. (2002). Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol 159(6): 923-929.
  17. Parone, P. A., James, D. and Martinou, J. C. (2002). Mitochondria: regulating the inevitable. Biochimie 84(2-3): 105-111.
  18. Virdee, K.*, Parone, P. A.* and Tolkovsky, A. M. (2000). Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival. Curr Biol 10(18): 1151-1154. *Co-first authors
Protocols by Philippe A. Parone
  1. Mitochondrial Isolation and Purification from Mouse Spinal Cord