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Jan R. De Mey


Ph.D. in Neuroendocrinology, University of Ghent, Belgium, 1975

Current position

Professor of Cell Biology at the Biotechnology School (ESBS) of the University of Strasbourg (10/2001-present)
Group Leader at Laboratory of Pharmacology and Biophotonics, UMR 7213, Illkirch (10/2001- present)
Director of the PIQ imaging platform of the Faculty of Pharmacy and the ESBS (2009-present)

Publications (selected)

  1. Michel, G., Matthes, H. W., Hachet-Haas, M., El Baghdadi, K., de Mey, J., Pepperkok, R., Simpson, J. C., Galzi, J. L. and Lecat, S. (2014). Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation. J Cell Sci 127(Pt 4): 773-787.
  2. Kolli-Bouhafs, K., Sick, E., Noulet, F., Gies, J. P., De Mey, J. and Ronde, P. (2014). FAK competes for Src to promote migration against invasion in melanoma cells. Cell Death Dis 5: e1379.  
  3. De Mey, J. R. and Freund, J. N. (2013). Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies. Tissue Barriers 1(2): e24965. 
  4. Brants, J., Semenchenko, K., Wasylyk, C., Robert, A., Carles, A., Zambrano, A., Pradeau-Aubreton, K., Birck, C., Schalken, J. A., Poch, O., de Mey, J. and Wasylyk, B. (2012). Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis. PLoS One 7(12): e51258.
  5. Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M. C., Dujardin, D., Formstone, C., Lightowler, S., Ramsay, R. G., Freund, J. N. and De Mey, J. R. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. J Cell Biol 198(3): 331-341.
  6.  Deramaudt, T. B., Dujardin, D., Hamadi, A., Noulet, F., Kolli, K., De Mey, J., Takeda, K. and Ronde, P. (2011). FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion. Mol Biol Cell 22(7): 964-975.
  7. Fritz, J. V., Dujardin, D., Godet, J., Didier, P., De Mey, J., Darlix, J. L., Mely, Y. and de Rocquigny, H. (2010). HIV-1 Vpr oligomerization but not that of Gag directs the interaction between Vpr and Gag. J Virol 84(3): 1585-1596. 
  8. Schaffner-Reckinger, E., Salsmann, A., Debili, N., Bellis, J., De Mey, J., Vainchenker, W., Ouwehand, W. H. and Kieffer, N. (2009). Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells. J Thromb Haemost 7(7): 1207-1217.
  9. De Mey, J. R., Kessler, P., Dompierre, J., Cordelieres, F. P., Dieterlen, A., Vonesch, J. L. and Sibarita, J. B. (2008). Fast 4D Microscopy. Methods Cell Biol 85: 83-112.
  10. Angelier, N., Tramier, M., Louvet, E., Coppey-Moisan, M., Savino, T. M., De Mey, J. R. and Hernandez-Verdun, D. (2005). Tracking the interactions of rRNA processing proteins during nucleolar assembly in living cells. Mol Biol Cell 16(6): 2862-2871.
  11. Gauthier, L. R., Charrin, B. C., Borrell-Pages, M., Dompierre, J. P., Rangone, H., Cordelieres, F. P., De Mey, J., MacDonald, M. E., Lessmann, V., Humbert, S. and Saudou, F. (2004). Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118(1): 127-138.
  12. Jacquet, M., Renault, G., Lallet, S., De Mey, J. and Goldbeter, A. (2003). Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae. J Cell Biol 161(3): 497-505.   
  13. Caspi, M., Coquelle, F. M., Koifman, C., Levy, T., Arai, H., Aoki, J., De Mey, J. R. and Reiner, O. (2003). LIS1 missense mutations: variable phenotypes result from unpredictable alterations in biochemical and cellular properties. J Biol Chem 278(40): 38740-38748.  
  14. Sibarita, J. B., Magnin, H. and De Mey, J. R. (2002). Ultra-fast 4D microscopy and high throughput distributed deconvolution. Biomedical Imaging, 2002.
  15. Coquelle, F. M., Caspi, M., Cordelieres, F. P., Dompierre, J. P., Dujardin, D. L., Koifman, C., Martin, P., Hoogenraad, C. C., Akhmanova, A., Galjart, N., De Mey, J. R. and Reiner, O. (2002). LIS1, CLIP-170's key to the dynein/dynactin pathway. Mol Cell Biol 22(9): 3089-3102.
  16. Savino, T. M., Gebrane-Younes, J., De Mey, J., Sibarita, J. B. and Hernandez-Verdun, D. (2001). Nucleolar assembly of the rRNA processing machinery in living cells. J Cell Biol 153(5): 1097-1110.       
  17. Busson, S., Dujardin, D., Moreau, A., Dompierre, J. and De Mey, J. R. (1998). Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells. Curr Biol 8(9): 541-544.            
Protocols by Jan R. De Mey
  1. Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum