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Jean-Noël Freund

Education

Ph.D. in Cellular and Molecular Biology, University Louis Pasteur, Strasbourg, France, 1986

Current position

Director of the Unit UMR_S1113 of INSERM, University of Strasbourg

Leader of Team 1: Intestinal Identity: from Stem Cells to Pathology

Publications (since 2008)

  1. Gueant, J. L., Caillerez-Fofou, M., Battaglia-Hsu, S., Alberto, J. M., Freund, J. N., Dulluc, I., Adjalla, C., Maury, F., Merle, C., Nicolas, J. P., Namour, F. and Daval, J. L. (2013). Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie 95(5): 1033-1040.
  2. Pereira, B., Sousa, S., Barros, R., Carreto, L., Oliveira, P., Oliveira, C., Chartier, N. T., Plateroti, M., Rouault, J. P., Freund, J. N., Billaud, M. and Almeida, R. (2013). CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness. Nucleic Acids Res 41(7): 3986-3999.
  3. Chery, C., Hehn, A., Mrabet, N., Oussalah, A., Jeannesson, E., Besseau, C., Alberto, J. M., Gross, I., Josse, T., Gerard, P., Gueant-Rodriguez, R. M., Freund, J. N., Devignes, J., Bourgaud, F., Peyrin-Biroulet, L., Feillet, F. and Gueant, J. L. (2013). Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant. Biochimie 95(5): 995-1001.
  4. Badique, F., Stamov, D. R., Davidson, P. M., Veuillet, M., Reiter, G., Freund, J. N., Franz, C. M. and Anselme, K. (2013). Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization. Biomaterials 34(12): 2991-3001.
  5. Derbal-Wolfrom, L., Pencreach, E., Saandi, T., Aprahamian, M., Martin, E., Greferath, R., Tufa, E., Choquet, P., Lehn, J. M., Nicolau, C., Duluc, I. and Freund, J. N. (2013). Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2. Oncogene 32(36): 4313-4318.
  6. Freund, J. N. (2012). [Identity and intestinal pathologies: the Cdx2 homeotic gene]. Ann Pathol 32(5 Suppl): S24-27.
  7. Abdallah Hajj Hussein, I., Freund, J. N., Reimund, J. M., Shams, A., Yamine, M., Leone, A. and Jurjus, A. R. (2012). Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi. J Biol Regul Homeost Agents 26(3): 515-526.
  8. Saandi, T., Baraille, F., Derbal-Wolfrom, L., Cattin, A. L., Benahmed, F., Martin, E., Cardot, P., Duclos, B., Ribeiro, A., Freund, J. N. and Duluc, I. (2013). Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer. Oncogene 32(32): 3782-3788.
  9. Barros, R., Freund, J. N., David, L. and Almeida, R. (2012). Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends Mol Med 18(9): 555-563.
  10. Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M. C., Dujardin, D., Formstone, C., Lightowler, S., Ramsay, R. G., Freund, J. N. and De Mey, J. R. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. J Cell Biol 198(3): 331-341.
  11. Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J. N. and Gross, I. (2012). Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and beta-catenin activity in colon cancer cells. Gastroenterology 142(4): 875-885 e873.
  12. Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J. N., Deschamps, J. and Beck, F. (2012). Cdx2 determines the fate of postnatal intestinal endoderm. Development 139(3): 465-474.
  13. Renouf, B., Soret, C., Saandi, T., Delalande, F., Martin, E., Vanier, M., Duluc, I., Gross, I., Freund, J. N. and Domon-Dell, C. (2012). Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. Nucleic Acids Res 40(8): 3456-3469.
  14. Kocgozlu, L., Rabineau, M., Koenig, G., Haikel, Y., Schaaf, P., Freund, J. N., Voegel, J. C., Lavalle, P. and Vautier, D. (2012). The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity. Biomaterials 33(3): 798-809.
  15. van de Ven, C., Bialecka, M., Neijts, R., Young, T., Rowland, J. E., Stringer, E. J., Van Rooijen, C., Meijlink, F., Novoa, A., Freund, J. N., Mallo, M., Beck, F. and Deschamps, J. (2011). Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development 138(16): 3451-3462.
  16. Entz-Werle, N., Choquet, P., Neuville, A., Kuchler-Bopp, S., Clauss, F., Danse, J. M., Simo-Noumbissie, P., Guerin, E., Gaub, M. P., Freund, J. N., Boehm, N., Constantinesco, A., Lutz, P., Guenot, D. and Perrin-Schmitt, F. (2010). Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Transl Oncol 3(6): 344-353.
  17. Barros, R., da Costa, L. T., Pinto-de-Sousa, J., Duluc, I., Freund, J. N., David, L. and Almeida, R. (2011). CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut 60(3): 290-298.
  18. Laurent, C., Svrcek, M., Flejou, J. F., Chenard, M. P., Duclos, B., Freund, J. N. and Reimund, J. M. (2011). Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer. Inflamm Bowel Dis 17(1): 232-240.
  19. Martin, E., Vanier, M., Tavian, M., Guerin, E., Domon-Dell, C., Duluc, I., Gross, I., Rowland, J., Kim, S. and Freund, J. N. (2010). CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula. Pediatrics 126(3): e723-727.
  20. Coant, N., Ben Mkaddem, S., Pedruzzi, E., Guichard, C., Treton, X., Ducroc, R., Freund, J. N., Cazals-Hatem, D., Bouhnik, Y., Woerther, P. L., Skurnik, D., Grodet, A., Fay, M., Biard, D., Lesuffleur, T., Deffert, C., Moreau, R., Groyer, A., Krause, K. H., Daniel, F. and Ogier-Denis, E. (2010). NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Mol Cell Biol 30(11): 2636-2650.
  21. Barros, R., Camilo, V., Pereira, B., Freund, J. N., David, L. and Almeida, R. (2010). Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation. Biochem Soc Trans 38(2): 358-363.
  22. Young, T., Rowland, J. E., van de Ven, C., Bialecka, M., Novoa, A., Carapuco, M., van Nes, J., de Graaff, W., Duluc, I., Freund, J. N., Beck, F., Mallo, M. and Deschamps, J. (2009). Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev Cell 17(4): 516-526.
  23. Pons, L., Battaglia-Hsu, S. F., Orozco-Barrios, C. E., Ortiou, S., Chery, C., Alberto, J. M., Arango-Rodriguez, M. L., Dumas, D., Martinez-Fong, D., Freund, J. N. and Gueant, J. L. (2009). Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin. PLoS One 4(7): e6325.
  24. Modica, S., Morgano, A., Salvatore, L., Petruzzelli, M., Vanier, M. T., Valanzano, R., Esposito, D. L., Palasciano, G., Duluc, I., Freund, J. N., Mariani-Costantini, R. and Moschetta, A. (2009). Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2. Gut 58(9): 1250-1259.
  25. Salehi, S., Eckley, L., Sawyer, G. J., Zhang, X., Dong, X., Freund, J. N. and Fabre, J. W. (2009). Intestinal lactase as an autologous beta-galactosidase reporter gene for in vivo gene expression studies. Hum Gene Ther 20(1): 21-30.
  26. Benahmed, F., Gross, I., Gaunt, S. J., Beck, F., Jehan, F., Domon-Dell, C., Martin, E., Kedinger, M., Freund, J. N. and Duluc, I. (2008). Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology 135(4): 1238-1247, 1247 e1231-1233.
  27. Hajj Hussein, I. A., Tohme, R., Barada, K., Mostafa, M. H., Freund, J. N., Jurjus, R. A., Karam, W. and Jurjus, A. (2008). Inflammatory bowel disease in rats: bacterial and chemical interaction. World J Gastroenterol 14(25): 4028-4039.
  28. Barros, R., Pereira, B., Duluc, I., Azevedo, M., Mendes, N., Camilo, V., Jacobs, R. J., Paulo, P., Santos-Silva, F., van Seuningen, I., van den Brink, G. R., David, L., Freund, J. N. and Almeida, R. (2008). Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. J Pathol 215(4): 411-420.
  29. Bonhomme, C., Calon, A., Martin, E., Robine, S., Neuville, A., Kedinger, M., Domon-Dell, C., Duluc, I. and Freund, J. N. (2008). Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. Oncogene 27(32): 4497-4502.
  30. Lu, X., Freund, J. N., Muller, M., Ravey, J., Nicolas, J. P., Gueant, J. L. and Namour, F. (2008). Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. Biochimie 90(5): 697-704.
Protocols by Jean-Noël Freund
  1. Immunolabelling of Thin Slices of Mouse Descending Colon and Jejunum