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Guillermo  A. Gomez

Guillermo A. Gomez


Ph.D. in Chemistry Sciences, National University of Cordoba, Argentina, 2007

Current position

Research Officer, Division of Molecular Cell Biology, Yap Group, Institute for Molecular Bioscience, University of Queensland, Australia

Research focus: My research is focused on understanding how mechanical force contributes to the biology of cell-cell interactions. By studying how cadherin cell-cell adhesion receptors sense force at cell-cell junctions, we want to elucidate the signalling pathways that generate cellular responses to junctional force. Our research will contribute to the rapidly-developing area of mechanobiology that has major implications for basic and biomedical science. Increasingly, it is evident that force sensing and mechanical tension affects many aspects of cell and tissue biology, from stem cell differentiation to cancer progression.


  1. Pedro, M.P., Vilcaes, A.A., Tomatis, V.M., Gomez, G.A. and Daniotti, J.L. (2013). 2-bromopalmitate reduces protein deacylation in vivo by inhibition of APT1 and APT2 enzymatic activities. PLos One In press
  2. Priya, R., Yap, A. S. and Gomez, G. A. (2013). E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens. Differentiation 86(3): 133-140.
  3. Verma, S., Han, S. P., Michael, M., Gomez, G. A., Yang, Z., Teasdale, R. D., Ratheesh, A., Kovacs, E. M., Ali, R. G. and Yap, A. S. (2012). A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens. Mol Biol Cell 23(23): 4601-4610.
  4. Ratheesh, A.*, Gomez, G. A.*, Priya, R., Verma, S., Kovacs, E. M., Jiang, K., Brown, N. H., Akhmanova, A., Stehbens, S. J. and Yap, A. S. (2012). Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nat Cell Biol 14(8): 818-828. *Contribute equally to this article (This article was Subject of Nature Cell Biology News & Views, 14, 784-786; Highlighted in Nature Reviews Mol Cell Biol, 13, 481; August 2012; and received 3/5 recommendations must read on F1000)
  5. Ferrari, M. L., Gomez, G. A. and Maccioni, H. J. (2012). Spatial organization and stoichiometry of N-terminal domain-mediated glycosyltransferase complexes in Golgi membranes determined by fret microscopy. Neurochem Res 37(6): 1325-1334.
  6. Gomez, G. A., McLachlan, R. W. and Yap, A. S. (2011). Productive tension: force-sensing and homeostasis of cell-cell junctions. Trends Cell Biol 21(9): 499-505.
  7. Smutny, M., Wu, S. K., Gomez, G. A., Mangold, S., Yap, A. S. and Hamilton, N. A. (2011). Multicomponent analysis of junctional movements regulated by myosin II isoforms at the epithelial zonula adherens. PLoS One 6(7): e22458.
  8. Levingston Macleod, J. M., D'Antuono, A., Loureiro, M. E., Casabona, J. C., Gomez, G. A. and Lopez, N. (2011). Identification of two functional domains within the arenavirus nucleoprotein. J Virol 85(5): 2012-2023.
  9. Tomatis, V. M., Trenchi, A., Gomez, G. A. and Daniotti, J. L. (2010). Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. PLoS One 5(11): e15045.
  10. Trenchi, A.*, Gomez, G. A.* and Daniotti, J. L. (2009). Dual acylation is required for trafficking of growth-associated protein-43 (GAP-43) to endosomal recycling compartment via an Arf6-associated endocytic vesicular pathway. Biochem J 421(3): 357-369. *Contribute equally to this article
  11. Casabona, J. C., Levingston Macleod, J. M., Loureiro, M. E., Gomez, G. A. and Lopez, N. (2009). The RING domain and the L79 residue of Z protein are involved in both the rescue of nucleocapsids and the incorporation of glycoproteins into infectious chimeric arenavirus-like particles. J Virol 83(14): 7029-7039.
  12. Gomez, G. A. and Daniotti, J. L. (2007). Electrical properties of plasma membrane modulate subcellular distribution of K-Ras. FEBS J 274(9): 2210-2228.
  13. Iglesias-Bartolome, R., Crespo, P. M., Gomez, G. A. and Daniotti, J. L. (2006). The antibody to GD3 ganglioside, R24, is rapidly endocytosed and recycled to the plasma membrane via the endocytic recycling compartment. Inhibitory effect of brefeldin A and monensin. FEBS J 273(8): 1744-1758.
  14. Gomez, G. A. and Daniotti, J. L. (2005). H-Ras dynamically interacts with recycling endosomes in CHO-K1 cells: involvement of Rab5 and Rab11 in the trafficking of H-Ras to this pericentriolar endocytic compartment. J Biol Chem 280(41): 34997-35010.
Protocols by Guillermo A. Gomez
  1. Measurement of Junctional Protein Dynamics Using Fluorescence Recovery After Photobleaching (FRAP)
  2. Analysis of Myosin II Minifilament Orientation at Epithelial Zonula Adherens
  3. Measurement of Mechanical Tension at cell-cell junctions using two-photon laser ablation