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Nathalie Morin


Ph.D. in Biology and Health, Virology (Inserm U233), University of Sciences Lille I, France, 1986

Current position

Group Leader, Team “Mechanisms of Mitosis” (CNRS UMR 5237), Montpellier, France

Publications (since 1994)

  1. Bompard, G., Rabeharivelo, G., Cau, J., Abrieu, A., Delsert, C. and Morin, N. (2013). P21-activated kinase 4 (PAK4) is required for metaphase spindle positioning and anchoring. Oncogene 32(7): 910-919.
  2. Bompard, G. and Morin, N. (2012). p21-activated kinase 4 regulates mitotic spindle positioning and orientation. Bioarchitecture 2(4).
  3. Morin, V., Prieto, S., Melines, S., Hem, S., Rossignol, M., Lorca, T., Espeut, J., Morin, N. and Abrieu, A. (2012). CDK-dependent potentiation of MPS1 kinase activity is essential to the mitotic checkpoint. Curr Biol 22(4): 289-295.
  4. Fort, P., Guemar, L., Vignal, E., Morin, N., Notarnicola, C., de Santa Barbara, P. and Faure, S. (2011). Activity of the RhoU/Wrch1 GTPase is critical for cranial neural crest cell migration. Dev Biol 350(2): 451-463.
  5. Bompard, G., Rabeharivelo, G., Frank, M., Cau, J., Delsert, C. and Morin, N. (2010). Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis. J Cell Biol 190(5): 807-822.
  6. Bompard, G., Rabeharivelo, G. and Morin, N. (2008). Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway. BMC Cell Biol 9: 42.
  7. Pascreau, G., Delcros, J. G., Morin, N., Prigent, C. and Arlot-Bonnemains, Y. (2008). Aurora-A kinase Ser349 phosphorylation is required during Xenopus laevis oocyte maturation. Dev Biol 317(2): 523-530.
  8. Wu, C. F., Delsert, C., Faure, S., Traverso, E. E., Kloc, M., Kuang, J., Etkin, L. D. and Morin, N. (2007). Tumorhead distribution to cytoplasmic membrane of neural plate cells is positively regulated by Xenopus p21-activated kinase 1 (X-PAK1). Dev Biol 308(1): 169-186.
  9. Krasinska, L., de Bettignies, G., Fisher, D., Abrieu, A., Fesquet, D. and Morin, N. (2007). Regulation of multiple cell cycle events by Cdc14 homologues in vertebrates. Exp Cell Res 313(6): 1225-1239.
  10. Faure, S., Cau, J., de Santa Barbara, P., Bigou, S., Ge, Q., Delsert, C. and Morin, N. (2005). Xenopus p21-activated kinase 5 regulates blastomeres' adhesive properties during convergent extension movements. Dev Biol 277(2): 472-492.
  11. Saoudi, Y., Rousseau, B., Doussiere, J., Charrasse, S., Gauthier-Rouviere, C., Morin, N., Sautet-Laugier, C., Denarier, E., Scaife, R., Mioskowski, C. and Job, D. (2004). Calcium-independent cytoskeleton disassembly induced by BAPTA. Eur J Biochem 271(15): 3255-3264.
  12. Rousseau, V., Goupille, O., Morin, N. and Barnier, J. V. (2003). A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases. J Biol Chem 278(6): 3912-3920.
  13. Cau, J., Faure, S., Comps, M., Delsert, C. and Morin, N. (2001). A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization. J Cell Biol 155(6): 1029-1042.
  14. Cau, J., Faure, S., Vigneron, S., Labbe, J. C., Delsert, C. and Morin, N. (2000). Regulation of Xenopus p21-activated kinase (X-PAK2) by Cdc42 and maturation-promoting factor controls Xenopus oocyte maturation. J Biol Chem 275(4): 2367-2375.
  15. Faure, S., Vigneron, S., Galas, S., Brassac, T., Delsert, C. and Morin, N. (1999). Control of G2/M transition in Xenopus by a member of the p21-activated kinase (PAK) family: a link between protein kinase A and PAK signaling pathways? J Biol Chem 274(6): 3573-3579.
  16. Fisher, D. L., Morin, N. and Doree, M. (1999). A novel role for glycogen synthase kinase-3 in Xenopus development: maintenance of oocyte cell cycle arrest by a beta-catenin-independent mechanism. Development 126(3): 567-576.
  17. Lorca, T., Castro, A., Martinez, A. M., Vigneron, S., Morin, N., Sigrist, S., Lehner, C., Doree, M. and Labbe, J. C. (1998). Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts. EMBO J 17(13): 3565-3575.
  18. Faure, S., Morin, N. and Doree, M. (1998). Inactivation of protein kinase A is not required for c-mos translation during meiotic maturation of Xenopus oocytes. Oncogene 17(10): 1215-1221.
  19. Roghi, C., Giet, R., Uzbekov, R., Morin, N., Chartrain, I., Le Guellec, R., Couturier, A., Doree, M., Philippe, M. and Prigent, C. (1998). The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly. J Cell Sci 111 ( Pt 5): 557-572.
  20. Fesquet, D., Morin, N., Doree, M. and Devault, A. (1997). Is Cdk7/cyclin H/MAT1 the genuine cdk activating kinase in cycling Xenopus egg extracts? Oncogene 15(11): 1303-1307.
  21. Faure, S., Vigneron, S., Doree, M. and Morin, N. (1997). A member of the Ste20/PAK family of protein kinases is involved in both arrest of Xenopus oocytes at G2/prophase of the first meiotic cell cycle and in prevention of apoptosis. EMBO J 16(18): 5550-5561.
  22. Delsert, C., Morin, N. and Comps, M. (1997). A fish encephalitis virus that differs from other nodaviruses by its capsid protein processing. Arch Virol 142(12): 2359-2371.
  23. Delsert, C., Morin, N. and Comps, M. (1997). Fish nodavirus lytic cycle and semipermissive expression in mammalian and fish cell cultures. J Virol 71(7): 5673-5677.
  24. Abrieu, A., Lorca, T., Labbe, J. C., Morin, N., Keyse, S. and Doree, M. (1996). MAP kinase does not inactivate, but rather prevents the cyclin degradation pathway from being turned on in Xenopus egg extracts. J Cell Sci 109 ( Pt 1): 239-246.
  25. Ohresser, M., Morin, N., Cerutti, M. and Delsert, C. (1995). Sequence analysis and transcriptional mapping of the orf-2 gene of Autographa californica nuclear polyhedrosis virus. Gene 152(2): 201-204.
  26. Carriere, C., Gay, B., Chazal, N., Morin, N. and Boulanger, P. (1995). Sequence requirements for encapsidation of deletion mutants and chimeras of human immunodeficiency virus type 1 Gag precursor into retrovirus-like particles. J Virol 69(4): 2366-2377.
  27. Doree, M., Le Peuch, C. and Morin, N. (1995). Onset of chromosome segregation at the metaphase to anaphase transition of the cell cycle. Prog Cell Cycle Res 1: 309-318.
  28. Devault, A., Martinez, A. M., Fesquet, D., Labbe, J. C., Morin, N., Tassan, J. P., Nigg, E. A., Cavadore, J. C. and Doree, M. (1995). MAT1 ('menage a trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK. EMBO J 14(20): 5027-5036.
  29. Labbe, J. C., Martinez, A. M., Fesquet, D., Capony, J. P., Darbon, J. M., Derancourt, J., Devault, A., Morin, N., Cavadore, J. C. and Doree, M. (1994). p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes. EMBO J 13(21): 5155-5164.
  30. Morin, N., Abrieu, A., Lorca, T., Martin, F. and Doree, M. (1994). The proteolysis-dependent metaphase to anaphase transition: calcium/calmodulin-dependent protein kinase II mediates onset of anaphase in extracts prepared from unfertilized Xenopus eggs. EMBO J 13(18): 4343-4352.
  31. Ohresser, M., Morin, N., Cerutti, M. and Delsert, C. (1994). Temporal regulation of a complex and unconventional promoter by viral products. J Virol 68(4): 2589-2597.
Protocols by Nathalie Morin
  1. Spindle Angle Measurements