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Yuh-Pyng   Sher

Yuh-Pyng Sher


Ph.D., Institute of Molecular Medicine, College of Medicine, National Taiwan University

Current position

Assistant Professor in Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

Publications (since 1998)


  1. Su, P. Y., Liu, S.J., Chen, Y. H., Wu, S. S., Chen, Y. L., Ke, J. R., Peng, C. Y. and Sher, Y. P*. (2013). Increased IL-8 and IL-1β in the bile of acute cholecystitis patients. BioMedicine. In press
  2. Liu, Y. J., Lin, Y. F., Chen, Y. F., Luo, E. C., Sher, Y. P., Tsai, M. H., Chuang, E. Y. and Lai, L. C.* (2013). MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells. PLoS One 8(4): e62383.
  3. Chi, C. Y., Chu, C. C., Liu, J. P., Lin, C. H., Ho, M. W., Lo, W. J., Lin, P. C., Chen, H. J., Chou, C. H., Feng, J. Y., Fung, C. P., Sher, Y. P., Li, C. Y., Wang, J. H. and Ku, C. L.* (2013). Anti-IFN-γ autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection. Blood 121(8): 1357-1366.
  4. Lee, D. F., Su, J., Ang, Y. S., Carvajal-Vergara, X., Mulero-Navarro, S., Pereira, C. F., Gingold, J., Wang, H. L., Zhao, R., Sevilla, A., Darr, H., Williamson, A. J., Chang, B., Niu, X., Aguilo, F., Flores, E. R., Sher, Y. P., Hung, M. C., Whetton, A. D., Gelb, B. D., Moore, K. A., Snoeck, H. W., Ma'ayan, A., Schaniel, C.* and Lemischka, I. R.* (2012). Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell 11(2): 179-194.
  5. Sher, Y. P., Chang, C. M., Juo, C. G., Chen, C. T., Hsu, J. L., Lin, C. Y., Han, Z., Shiah, S. G. and Hung, M. C.* (2013). Targeted endostatin-cytosine deaminase fusion gene therapy plus 5-fluorocytosine suppresses ovarian tumor growth. Oncogene 32(9): 1082-1090.
  6. Tu, S. H., Huang, H. I., Lin, S. I., Liu, H. Y., Sher, Y. P., Chiang, S. K., Chong, P., Roffler, S., Tseng, G. C., Chen, H. W. and Liu, S. J.* (2012). A novel HLA-A2-restricted CTL epitope of tumor-associated antigen L6 can inhibit tumor growth in vivo. J Immunother 35(3): 235-244.
  7. Lai, L. C., Su, Y. Y., Chen, K. C., Tsai, M. H., Sher, Y. P., Lu, T. P., Lee, C. Y. and Chuang, E. Y.* (2011). Down-regulation of NDRG1 promotes migration of cancer cells during reoxygenation. PLoS One 6(8): e24375.
  8. Li, L. Y.*, Chen, H., Hsieh, Y. H., Wang, Y. N., Chu, H. J., Chen, Y. H., Chen, H. Y., Chien, P. J., Ma, H. T., Tsai, H. C., Lai, C. C., Sher, Y. P., Lien, H. C., Tsai, C. H. and Hung, M. C.* (2011). Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. Cancer Res 71(12): 4269-4279.
  9. Sher, Y. P., Liu, S. J., Chang, C. M., Lien, S. P., Chen, C. H., Han, Z., Li, L. Y., Chen, J. S., Wu, C. W. and Hung, M. C.* (2011). Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer. Mol Cancer Ther 10(4): 637-647.
  10. Li, L. Y.*, Dai, H. Y., Yeh, F. L., Kan, S. F., Lang, J., Hsu, J. L., Jeng, L. B., Chen, Y. H., Sher, Y. P., Lin, W. C. and Hung, M. C.* (2011). Targeted hepatocellular carcinoma proapoptotic BikDD gene therapy. Oncogene 30(15): 1773-1783.
  11. Leng, C. H., Chen, H. W., Chang, L. S., Liu, H. H., Liu, H. Y., Sher, Y. P., Chang, Y. W., Lien, S. P., Huang, T. Y., Chen, M. Y., Chou, A. H., Chong, P. and Liu, S. J.* (2010). A recombinant lipoprotein containing an unsaturated fatty acid activates NF-κB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide. Mol Immunol 47(11-12): 2015-2021.
  12. Sher, Y. P., Tzeng, T. F., Kan, S. F., Hsu, J., Xie, X., Han, Z., Lin, W. C., Li, L. Y.* and Hung, M. C.* (2009). Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival. Oncogene 28(37): 3286-3295.
  13. Liu, S. J., Tsai, J. P., Shen, C. R., Sher, Y. P., Hsieh, C. L., Yeh, Y. C., Chou, A. H., Chang, S. R., Hsiao, K. N., Yu, F. W. and Chen, H. W.* (2007). Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J Leukoc Biol 82(2): 354-360.
  14. Sher, Y. P., Chou, C. C., Chou, R. H., Wu, H. M., Wayne Chang, W. S., Chen, C. H., Yang, P. C., Wu, C. W., Yu, C. L. and Peck, K.* (2006). Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness. Cancer Res 66(24): 11763-11770.
  15. Sher, Y. P., Shih, J. Y., Yang, P. C., Roffler, S. R., Chu, Y. W., Wu, C. W., Yu, C. L. and Peck, K.* (2005). Prognosis of non-small cell lung cancer patients by detecting circulating cancer cells in the peripheral blood with multiple marker genes. Clin Cancer Res 11(1): 173-179.
  16. Huang, W., Sher, Y. P., Peck, K. and Fung, Y. C.* (2002). Matching gene activity with physiological functions. Proc Natl Acad Sci U S A 99(5): 2603-2608.
  17. Chen, J. J., Peck, K., Hong, T. M., Yang, S. C., Sher, Y. P., Shih, J. Y., Wu, R., Cheng, J. L., Roffler, S. R., Wu, C. W. and Yang, P. C.* (2001). Global analysis of gene expression in invasion by a lung cancer model. Cancer Res 61(13): 5223-5230.
  18. Yoneda, K., Peck, K., Chang, M. M., Chmiel, K., Sher, Y. P., Chen, J., Yang, P. C., Chen, Y. and Wu, R.* (2001). Development of high-density DNA microarray membrane for profiling smoke- and hydrogen peroxide-induced genes in a human bronchial epithelial cell line. Am J Respir Crit Care Med 164(10 Pt 2): S85-89.
  19. Huang, W., Sher, Y. P., Delgado-West, D., Wu, J. T., Peck, K. and Fung, Y. C.* (2001). Tissue remodeling of rat pulmonary artery in hypoxic breathing. I. Changes of morphology, zero-stress state, and gene expression. Ann Biomed Eng 29(7): 535-551.
  20. Huang, W., Sher, Y. P., Peck, K. and Fung, Y. C.* (2001). Correlation of gene expression with physiological functions: Examples of pulmonary blood vessel rheology, hypoxic hypertension, and tissue remodeling. Biorheology 38(2-3): 75-87.
  21. Peck, K., Sher, Y. P., Shih, J. Y., Roffler, S. R., Wu, C. W. and Yang, P. C.* (1998). Detection and quantitation of circulating cancer cells in the peripheral blood of lung cancer patients. Cancer Res 58(13): 2761-2765.
  22. Liu, S. J., Sher, Y. P., Ting, C. C., Liao, K. W., Yu, C. P. and Tao, M. H.* (1998). Treatment of B-cell lymphoma with chimeric IgG and single-chain Fv antibody-interleukin-2 fusion proteins. Blood 92(6): 2103-2112.
  23. Chen, J. J., Wu, R., Yang, P. C., Huang, J. Y., Sher, Y. P., Han, M. H., Kao, W. C., Lee, P. J., Chiu, T. F., Chang, F., Chu, Y. W., Wu, C. W. and Peck, K.* (1998). Profiling expression patterns and isolating differentially expressed genes by cDNA microarray system with colorimetry detection. Genomics 51(3): 313-324.

    *Correspondence author

Book chapters

  1. Peck, K. and Sher, Y. P. (2001). cDNA Microarrays on Nylon Filter Membrane With Colorimetric Detection in DNA Microarrays: Gene Expression Applications ed. Bertrand R. Jordan, Springer-Verlag, 35-54.
  2. Peck, K. and Sher, Y. P. (2001). Application of Enzyme Colorimetry for cDNA Microarray Detection in BioChip Technology, eds. Jing Cheng & Larry J. Kricka, Harwood Academic Publishers, 325-340.

Protocols by Yuh-Pyng Sher
  1. Blood AST, ALT and UREA/BUN Level Analysis