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Jeffrey W. Tyner

Education

N.A. in Hematology/Oncology, Oregon Health & Science University (OHSU), 2010

Ph.D. in Molecular Cell Biology, Washington University in St. Louis, 2005

Current position

Assistant Professor, Department of Cell & Developmental Biology, OHSU

Publications

Peer-reviewed publications (total of 50)

  1. Maxson, J. E., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S. K., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Oh, S. T., Deininger, M. W., Chang, B. H., Loriaux, M. M., Druker, B. J. and Tyner, J. W. (2013). Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med 368(19): 1781-1790.
  2. Sanda, T.*, Tyner, J. W.*, Gutierrez, A., Ngo, V. N., Glover, J., Chang, B. H., Yost, A., Ma, W., Fleischman, A. G., Zhou, W., Yang, Y., Kleppe, M., Ahn, Y., Tatarek, J., Kelliher, M. A., Neuberg, D. S., Levine, R. L., Moriggl, R., Muller, M., Gray, N. S., Jamieson, C. H., Weng, A. P., Staudt, L. M., Druker, B. J. and Look, A. T. (2013). TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov 3(5): 564-577. *Denotes Equal Contribution
  3. Tyner, J. W., Yang, W. F., Bankhead, A., 3rd, Fan, G., Fletcher, L. B., Bryant, J., Glover, J. M., Chang, B. H., Spurgeon, S. E., Fleming, W. H., Kovacsovics, T., Gotlib, J. R., Oh, S. T., Deininger, M. W., Zwaan, C. M., Den Boer, M. L., van den Heuvel-Eibrink, M. M., O'Hare, T., Druker, B. J. and Loriaux, M. M. (2013). Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening. Cancer Res 73(1): 285-296.
  4. Bicocca, V. T., Chang, B. H., Masouleh, B. K., Muschen, M., Loriaux, M. M., Druker, B. J. and Tyner, J. W. (2012). Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia. Cancer Cell 22(5): 656-667.
  5. Tyner, J. W., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M., Heinrich, M. C., Deininger, M. W., Druker, B. J. and Loriaux, M. M. (2010). MET receptor sequence variants R970C and T992I lack transforming capacity. Cancer Res 70(15): 6233-6237.
  6. Tyner, J. W., Bumm, T. G., Deininger, J., Wood, L., Aichberger, K. J., Loriaux, M. M., Druker, B. J., Burns, C. J., Fantino, E. and Deininger, M. W. (2010). CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood 115(25): 5232-5240.
  7. Tyner, J. W., Deininger, M. W., Loriaux, M. M., Chang, B. H., Gotlib, J. R., Willis, S. G., Erickson, H., Kovacsovics, T., O'Hare, T., Heinrich, M. C. and Druker, B. J. (2009). RNAi screen for rapid therapeutic target identification in leukemia patients. Proc Natl Acad Sci U S A 106(21): 8695-8700.
  8. Tyner, J. W., Rutenberg-Schoenberg, M. L., Erickson, H., Willis, S. G., O'Hare, T., Deininger, M. W., Druker, B. J. and Loriaux, M. M. (2009). Functional characterization of an activating TEK mutation in acute myeloid leukemia: a cellular context-dependent activating mutation. Leukemia 23(7): 1345-1348.
  9. Tyner, J. W., Erickson, H., Deininger, M. W., Willis, S. G., Eide, C. A., Levine, R. L., Heinrich, M. C., Gattermann, N., Gilliland, D. G., Druker, B. J. and Loriaux, M. M. (2009). High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients. Blood 113(8): 1749-1755.
  10. Tyner, J. W., Loriaux, M. M., Erickson, H., Eide, C. A., Deininger, J., MacPartlin, M., Willis, S. G., Lange, T., Druker, B. J., Kovacsovics, T., Maziarz, R., Gattermann, N. and Deininger, M. W. (2009). High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia. Leukemia 23(2): 406-409.
  11. O'Hare, T., Eide, C. A., Tyner, J. W., Corbin, A. S., Wong, M. J., Buchanan, S., Holme, K., Jessen, K. A., Tang, C., Lewis, H. A., Romero, R. D., Burley, S. K. and Deininger, M. W. (2008). SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib. Proc Natl Acad Sci U S A 105(14): 5507-5512.
  12. Tyner, J. W., Walters, D. K., Willis, S. G., Luttropp, M., Oost, J., Loriaux, M., Erickson, H., Corbin, A. S., O'Hare, T., Heinrich, M. C., Deininger, M. W. and Druker, B. J. (2008). RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia. Blood 111(4): 2238-2245.
  13. Gu, T. L.*, Mercher, T.*, Tyner, J. W.*, Goss, V. L., Walters, D. K., Cornejo, M. G., Reeves, C., Popova, L., Lee, K., Heinrich, M. C., Rush, J., Daibata, M., Miyoshi, I., Gilliland, D. G., Druker, B. J. and Polakiewicz, R. D. (2007). A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood 110(1): 323-333. *Denotes Equal Contribution
  14. Tyner, J. W., Kim, E. Y., Ide, K., Pelletier, M. R., Roswit, W. T., Morton, J. D., Battaile, J. T., Patel, A. C., Patterson, G. A., Castro, M., Spoor, M. S., You, Y., Brody, S. L. and Holtzman, M. J. (2006). Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J Clin Invest 116(2): 309-321.
  15. Tyner, J. W., Uchida, O., Kajiwara, N., Kim, E. Y., Patel, A. C., O'Sullivan, M. P., Walter, M. J., Schwendener, R. A., Cook, D. N., Danoff, T. M. and Holtzman, M. J. (2005). CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nat Med 11(11): 1180-1187.
Protocols by Jeffrey W. Tyner
  1. Immunoprecipitation of ROR1
  2. ROR1 Flow Cytometry