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Andrea J. Tenner


Ph.D., University of California, San Diego, La Jolla, California, 1977

Current position

Professor, Department of Molecular Biology and Biochemistry, University of California, Irvine, CA

Professor, Department of Pathology and Laboratory Medicine, University of California School of Medicine, Irvine, CA

Professor, Department of Neurobiology and Behavior, University of California, Irvine, CA

Publications (since 2005)

  1. Cole, T.A. and Tenner, A. J. (2013). Complement Casade in Neurodegenerative Disease: Pinpointing Therapeutic Targets. Alzheimers Research & Therapy (invited review in Preparation).
  2. Cole,T.A., Fonseca, M.I., Chu, S-H., Benoit, M.E., Hernandez, M.X., Berci, A.M., Rocchi, A., Wetsel, R.A. and Tenner, A.J. (2013). Proinflammatory Receptor for Complement Component C5a as a Therapeutic Target for AD. In Preparation
  3. Stephan, A. H., Madison, D. V., Mateos, J. M., Fraser, D. A., Lovelett, E. A., Coutellier, L., Kim, L., Tsai, H. H., Huang, E. J., Rowitch, D. H., Berns, D. S., Tenner, A. J., Shamloo, M. and Barres, B. A. (2013). A Dramatic Increase of C1q Protein in the CNS during Normal Aging. J Neurosci 33(33): 13460-13474.
  4. Fonseca, M. I., McGuire, S. O., Counts, S. E. and Tenner, A. J. (2013). Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology. J Neuroinflammation 10: 25.
  5. Benoit, M. E., Hernandez, M. X., Dinh, M. L., Benavente, F., Vasquez, O. and Tenner, A. J. (2013). C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity. J Biol Chem 288(1): 654-665.
  6. Chandrasekhar, A., Dinasrapu, A. R., Tenner, A. J. and Subramaniam, S. (2012). Complement C1q subcomponent subunit A. UCSD Molecule Pages 1(2).
  7. Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J. and Cotman, C. W. (2012). Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation 9: 179.
  8. Benoit, M. E., Clarke, E. V., Morgado, P., Fraser, D. A. and Tenner, A. J. (2012). Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol 188(11): 5682-5693.
  9. Linnartz, B., Kopatz, J., Tenner, A. J. and Neumann, H. (2012). Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia. J Neurosci 32(3): 946-952.
  10. Veerhuis, R., Nielsen, H. M. and Tenner, A. J. (2011). Complement in the brain. Mol Immunol 48(14): 1592-1603.
  11. Fonseca, M. I., Chu, S. H., Berci, A. M., Benoit, M. E., Peters, D. G., Kimura, Y. and Tenner, A. J. (2011). Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease. J Neuroinflammation 8(1): 4.
  12. Benoit, M. E. and Tenner, A. J. (2011). Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. J Neurosci 31(9): 3459-3469.
  13. Fraser, D. A. and Tenner, A. J. (2010). Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages. J Immunol 185(7): 3932-3939.
  14. Zekavat, G., Mozaffari, R., Arias, V. J., Rostami, S. Y., Badkerhanian, A., Tenner, A. J., Nichols, K. E., Naji, A. and Noorchashm, H. (2010). A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state. Immunogenetics 62(6): 397-407.
  15. Ager, R. R., Fonseca, M. I., Chu, S. H., Sanderson, S. D., Taylor, S. M., Woodruff, T. M. and Tenner, A. J. (2010). Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease. J Neurochem 113(2): 389-401.
  16. Fraser, D. A., Pisalyaput, K. and Tenner, A. J. (2010). C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production. J Neurochem 112(3): 733-743.
  17. Woodruff, T. M., Ager, R. R., Tenner, A. J., Noakes, P. G. and Taylor, S. M. (2010). The role of the complement system and the activation fragment C5a in the central nervous system. Neuromolecular Med 12(2): 179-192.
  18. Fraser, D. A., Laust, A. K., Nelson, E. L. and Tenner, A. J. (2009). C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells. J Immunol 183(10): 6175-6185.
  19. Klos, A., Tenner, A. J., Johswich, K. O., Ager, R. R., Reis, E. S. and Kohl, J. (2009). The role of the anaphylatoxins in health and disease. Mol Immunol 46(14): 2753-2766.
  20. Fonseca, M. I., Ager, R. R., Chu, S. H., Yazan, O., Sanderson, S. D., LaFerla, F. M., Taylor, S. M., Woodruff, T. M. and Tenner, A. J. (2009). Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol 183(2): 1375-1383.
  21. Zhou, J., Fonseca, M. I., Pisalyaput, K. and Tenner, A. J. (2008). Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease. J Neurochem 106(5): 2080-2092.
  22. Alexander, J. J., Anderson, A. J., Barnum, S. R., Stevens, B. and Tenner, A. J. (2008). The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration. J Neurochem 107(5): 1169-1187.
  23. Li, M., Ager, R. R., Fraser, D. A., Tjokro, N. O. and Tenner, A. J. (2008). Development of a humanized C1q A chain knock-in mouse: assessment of antibody independent beta-amyloid induced complement activation. Mol Immunol 45(11): 3244-3252.
  24. Lillis, A. P., Greenlee, M. C., Mikhailenko, I., Pizzo, S. V., Tenner, A. J., Strickland, D. K. and Bohlson, S. S. (2008). Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol 181(1): 364-373.
  25. Fraser, D. A. and Tenner, A. J. (2008). Directing an appropriate immune response: the role of defense collagens and other soluble pattern recognition molecules. Curr Drug Targets 9(2): 113-122.
  26. Pisalyaput, K. and Tenner, A. J. (2008). Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms. J Neurochem 104(3): 696-707.
  27. Tenner, A.J. and Pisalyaput, K. (2008). The Complement System in the CNS: Thinking again. In Central Nervous System Diseases and Inflammation, Eds: Thomas E. Lane, Monica Carson, Connie Bergmann, Tony Wyss-Coray, Springer, New York (Invited Review), pp. 153-174.
  28. Fraser, D. A., Arora, M., Bohlson, S. S., Lozano, E. and Tenner, A. J. (2007). Generation of inhibitory NFkappaB complexes and phosphorylated cAMP response element-binding protein correlates with the anti-inflammatory activity of complement protein C1q in human monocytes. J Biol Chem 282(10): 7360-7367.
  29. Bohlson, S. S., Fraser, D. A. and Tenner, A. J. (2007). Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions. Mol Immunol 44(1-3): 33-43.
  30. Chong, Y. H., Shin, Y. J., Lee, E. O., Kayed, R., Glabe, C. G. and Tenner, A. J. (2006). ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. J Biol Chem 281(29): 20315-20325.
  31. Tenner, A. J. and Fonseca, M. I. (2006). The double-edged flower: roles of complement protein C1q in neurodegenerative diseases. Adv Exp Med Biol 586: 153-176.
  32. Fraser, D. A., Bohlson, S. S., Jasinskiene, N., Rawal, N., Palmarini, G., Ruiz, S., Rochford, R. and Tenner, A. J. (2006). C1q and MBL, components of the innate immune system, influence monocyte cytokine expression. J Leukoc Biol 80(1): 107-116.
  33. Osmers, I., Szalai, A. J., Tenner, A. J. and Barnum, S. R. (2006). Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated. Mol Immunol 43(10): 1722-1725.
  34. Zhou, J., Fonseca, M. I., Kayed, R., Hernandez, I., Webster, S. D., Yazan, O., Cribbs, D. H., Glabe, C. G. and Tenner, A. J. (2005). Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. J Neuroinflammation 2: 28.
  35. Bohlson, S. S., Silva, R., Fonseca, M. I. and Tenner, A. J. (2005). CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol 175(2): 1239-1247.
  36. Fan, R. and Tenner, A. J. (2005). Differential regulation of Abeta42-induced neuronal C1q synthesis and microglial activation. J Neuroinflammation 2(1): 1.
  37. Zhang, M., Bohlson, S. S., Dy, M. and Tenner, A. J. (2005). Modulated interaction of the ERM protein, moesin, with CD93. Immunology 115(1): 63-73.
  38. Bohlson, S. S., Zhang, M., Ortiz, C. E. and Tenner, A. J. (2005). CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis. J Leukoc Biol 77(1): 80-89.

Book Review

  1. Tenner, A.J. (1993). Review of Complement Profiles, Volume 1, Complement Today. edited by J.M. Cruse and R.E. Lewis, Jr. Karger, Basel, Switzerland, J. of Clinical Immunol. 14:1994.

Guest Editor

  1. Parker, C. J. and Tenner, A. J. (2001). Unraveling of mechanisms and discovering novel roles for complement in health and disease. International Immunopharmacology 1(3): 357-358.
  2. Tenner, A. J. (2004). Influence of innate immune responses on autoimmunity. Autoimmunity 37(2): 83-84.
Protocols by Andrea J. Tenner
  1. C1q Binding to and Uptake of Apoptotic Lymphocytes by Human Monocyte-derived Macrophages
  2. Purification of Human Monocytes and Lymphocyte Populations by Counter Current Elutriation – A Short Protocol