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Marie E. Benoit


Ph.D., University of Aix-Marseille II, Marseille, France, 2008

Current position

Research Scientist, Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia


  1. Benoit, M. E., Clarke, E. V. and Tenner, A. J. (2013). C1q binding to and uptake of apoptotic lymphocytes by human monocyte-derived macrophages. Bio-protocol, 3(17):http://www.bio-protocol.org/wenzhang.aspx?id=877.
  2. Benoit, M. E., Hernandez, M. X., Dinh, M. L., Benavente, F., Vasquez, O. and Tenner, A. J. (2013). C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity. J Biol Chem 288(1): 654-665.
  3. Benoit, M. E., Clarke, E. V., Morgado, P., Fraser, D. A. and Tenner, A. J. (2012). Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol 188(11): 5682-5693.
  4. Benoit, M. E. and Tenner, A. J. (2011). Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. J Neurosci 31(9): 3459-3469.
  5. Fonseca, M. I., Chu, S. H., Berci, A. M., Benoit, M. E., Peters, D. G., Kimura, Y. and Tenner, A. J. (2011). Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease. J Neuroinflammation 8(1): 4.
  6. Benoit, M., Thuny, F., Le Priol, Y., Lepidi, H., Bastonero, S., Casalta, J. P., Collart, F., Capo, C., Raoult, D. and Mege, J. L. (2010). The transcriptional programme of human heart valves reveals the natural history of infective endocarditis. PLoS One 5(1): e8939.
  7. Benoit, M., Bechah, Y., Capo, C., Murray, P. J., Mege, J. L. and Desnues, B. (2009). Role of the cytoplasmic pattern recognition receptor Nod2 in Coxiella burnetii infection. Clin Microbiol Infect 15 Suppl 2: 154-155.
  8. Benoit, M., Desnues, B. and Mege, J. L. (2008). Macrophage polarization in bacterial infections. J Immunol 181(6): 3733-3739. Review.
  9. Benoit, M., Ghigo, E., Capo, C., Raoult, D. and Mege, J. L. (2008). The uptake of apoptotic cells drives Coxiella burnetii replication and macrophage polarization: a model for Q fever endocarditis. PLoS Pathog 4(5): e1000066.
  10. Benoit, M., Barbarat, B., Bernard, A., Olive, D. and Mege, J. L. (2008). Coxiella burnetii, the agent of Q fever, stimulates an atypical M2 activation program in human macrophages. Eur J Immunol 38(4): 1065-1070.
  11. Benoit, M., Fenollar, F., Raoult, D. and Mege, J. L. (2007). Increased levels of circulating IL-16 and apoptosis markers are related to the activity of Whipple's disease. PLoS One 2(6): e494.
Protocols by Marie E. Benoit
  1. C1q Binding to and Uptake of Apoptotic Lymphocytes by Human Monocyte-derived Macrophages
  2. Purification of Human Monocytes and Lymphocyte Populations by Counter Current Elutriation – A Short Protocol