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Triantafillos Liloglou

Education

Ph.D., Medical School, University of Crete & Institute of Biological Research & Biotechnology, National Hellenic Research Foundation, Athens, Greece, 1994

Current position

Lecturer, University of Liverpool, Department of Molecular & Clinical Cancer Medicine

Biomarkers Group Leader, Liverpool CR-UK Centre

Publications (since 2009)

  1. J Sandoval, JMendez-Gonzalez, E Nadal, G Chen, F.J Carmona, S Sayols, S Moran, H Heyn, M Vizoso, A Gomez, M Sanchez-Cespedes, Y Assenov, F Muller, C Bock, M Taron, J Mora, L Muscarella, T Liloglou, MP Davies, M Pollan, M Pajares, W Torre, L Montuenga, E Brambilla, J Field, L Roz, M Lo Iacono, G Scagliotti, R Rosell, D Beer, MEsteller. A Prognostic DNA Methylation Signature for Stage I Non-Small Cell Lung Cancer. J Clin Oncol In Press
  2. D Barh, N Jain, S Tiwari, JK Field, E Padín, ARuibal, R López, A Bhattacharya, L Juneja,, C Viero, A Silva, A Miyoshi, A Kumar, K Blum, M Herranz, V Azevedo, T Liloglou. A novel in silico reverse-transcriptomics-based identification and blood-based validation of a panel of sub-type specific biomarkers in lung cancer. BMC Genomics In Press.
  3. Oleksiewicz, U., Liloglou, T., Tasopoulou, K. M., Daskoulidou, N., Bryan, J., Gosney, J. R., Field, J. K. and Xinarianos, G. (2013). Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. Hum Mol Genet 22(16): 3207-3217.
  4. Gkirtzimanaki, K., Gkouskou, K. K., Oleksiewicz, U., Nikolaidis, G., Vyrla, D., Liontos, M., Pelekanou, V., Kanellis, D. C., Evangelou, K., Stathopoulos, E. N., Field, J. K., Tsichlis, P. N., Gorgoulis, V., Liloglou, T. and Eliopoulos, A. G. (2013). TPL2 kinase is a suppressor of lung carcinogenesis. Proc Natl Acad Sci U S A 110(16): E1470-1479.
  5. Jithesh, P. V., Risk, J. M., Schache, A. G., Dhanda, J., Lane, B., Liloglou, T. and Shaw, R. J. (2013). The epigenetic landscape of oral squamous cell carcinoma. Br J Cancer 108(2): 370-379.
  6. Matthews, A. M., Kaur, H., Dodd, M., D'Souza, J., Liloglou, T., Shaw, R. J. and Risk, J. M. (2013). Saliva collection methods for DNA biomarker analysis in oral cancer patients. Br J Oral Maxillofac Surg 51(5): 394-398.
  7. Schache, A. G., Liloglou, T., Risk, J. M., Jones, T. M., Ma, X. J., Wang, H., Bui, S., Luo, Y., Sloan, P., Shaw, R. J. and Robinson, M. (2013). Validation of a novel diagnostic standard in HPV-positive oropharyngeal squamous cell carcinoma. Br J Cancer 108(6): 1332-1339.
  8. Balgkouranidou, I., Liloglou, T. and Lianidou, E. S. (2013). Lung cancer epigenetics: emerging biomarkers. Biomark Med 7(1): 49-58.
  9. Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., Liloglou, T., Zhang, J. E., Austin, G., Holyoake, T. L., Foroni, L., Kottaridis, P. D., Muller, M. C., Pirmohamed, M. and Clark, R. E. (2013). The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia. Blood 121(4): 628-637.
  10. Nikolaidis, G., Raji, O. Y., Markopoulou, S., Gosney, J. R., Bryan, J., Warburton, C., Walshaw, M., Sheard, J., Field, J. K. and Liloglou, T. (2012). DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. Cancer Res 72(22): 5692-5701.
  11. Shaw, R. J., Hobkirk, A. J., Nikolaidis, G., Woolgar, J. A., Triantafyllou, A., Brown, J. S., Liloglou, T. and Risk, J. M. (2013). Molecular Staging of Surgical Margins in Oral Squamous Cell Carcinoma Using Promoter Methylation of p16(INK4A), Cytoglobin, E-cadherin, and TMEFF2. Ann Surg Oncol 20(8): 2796-2802.
  12. Markopoulou, S., Nikolaidis, G. and Liloglou, T. (2012). DNA methylation biomarkers in biological fluids for early detection of respiratory tract cancer. Clin Chem Lab Med 50(10): 1723-1731.
  13. Timofeeva, M. N., Hung, R. J., Rafnar, T., Christiani, D. C., Field, J. K., Bickeboller, H., Risch, A., McKay, J. D., Wang, Y., Dai, J., Gaborieau, V., McLaughlin, J., Brenner, D., Narod, S. A., Caporaso, N. E., Albanes, D., Thun, M., Eisen, T., Wichmann, H. E., Rosenberger, A., Han, Y., Chen, W., Zhu, D., Spitz, M., Wu, X., Pande, M., Zhao, Y., Zaridze, D., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Krokan, H. E., Gabrielsen, M. E., Skorpen, F., Vatten, L., Njolstad, I., Chen, C., Goodman, G., Lathrop, M., Benhamou, S., Vooder, T., Valk, K., Nelis, M., Metspalu, A., Raji, O., Chen, Y., Gosney, J., Liloglou, T., Muley, T., Dienemann, H., Thorleifsson, G., Shen, H., Stefansson, K., Brennan, P., Amos, C. I., Houlston, R. and Landi, M. T. (2012). Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Hum Mol Genet 21(22): 4980-4995.
  14. Liloglou, T., Bediaga, N. G., Brown, B. R., Field, J. K. and Davies, M. P. (2012). Epigenetic biomarkers in lung cancer. Cancer Lett.
  15. Han, N., Dol, Z., Vasieva, O., Hyde, R., Liloglou, T., Raji, O., Brambilla, E., Brambilla, C., Martinet, Y., Sozzi, G., Risch, A., Montuenga, L. M., Brass, A. and Field, J. K. (2012). Progressive lung cancer determined by expression profiling and transcriptional regulation. Int J Oncol 41(1): 242-252.
  16. Dietrich, D., Kneip, C., Raji, O., Liloglou, T., Seegebarth, A., Schlegel, T., Flemming, N., Rausch, S., Distler, J., Fleischhacker, M., Schmidt, B., Giles, T., Walshaw, M., Warburton, C., Liebenberg, V. and Field, J. K. (2012). Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchial aspirates. Int J Oncol 40(3): 825-832.
  17. Schache, A. G., Liloglou, T., Risk, J. M., Filia, A., Jones, T. M., Sheard, J., Woolgar, J. A., Helliwell, T. R., Triantafyllou, A., Robinson, M., Sloan, P., Harvey-Woodworth, C., Sisson, D. and Shaw, R. J. (2011). Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. Clin Cancer Res 17(19): 6262-6271.
  18. Oleksiewicz, U., Liloglou, T., Field, J. K. and Xinarianos, G. (2011). Cytoglobin: biochemical, functional and clinical perspective of the newest member of the globin family. Cell Mol Life Sci 68(23): 3869-3883.
  19. Oleksiewicz, U., Daskoulidou, N., Liloglou, T., Tasopoulou, K., Bryan, J., Gosney, J. R., Field, J. K. and Xinarianos, G. (2011). Neuroglobin and myoglobin in non-small cell lung cancer: expression, regulation and prognosis. Lung Cancer 74(3): 411-418.
  20. McKay, J. D., Truong, T., Gaborieau, V., Chabrier, A., Chuang, S. C., Byrnes, G., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Holcatova, I., Janout, V., Foretova, L., Lagiou, P., Trichopoulos, D., Benhamou, S., Bouchardy, C., Ahrens, W., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Macfarlane, G. J., Macfarlane, T. V., Simonato, L., Canova, C., Agudo, A., Castellsague, X., Lowry, R., Conway, D. I., McKinney, P. A., Healy, C. M., Toner, M. E., Znaor, A., Curado, M. P., Koifman, S., Menezes, A., Wunsch-Filho, V., Neto, J. E., Garrote, L. F., Boccia, S., Cadoni, G., Arzani, D., Olshan, A. F., Weissler, M. C., Funkhouser, W. K., Luo, J., Lubinski, J., Trubicka, J., Lener, M., Oszutowska, D., Schwartz, S. M., Chen, C., Fish, S., Doody, D. R., Muscat, J. E., Lazarus, P., Gallagher, C. J., Chang, S. C., Zhang, Z. F., Wei, Q., Sturgis, E. M., Wang, L. E., Franceschi, S., Herrero, R., Kelsey, K. T., McClean, M. D., Marsit, C. J., Nelson, H. H., Romkes, M., Buch, S., Nukui, T., Zhong, S., Lacko, M., Manni, J. J., Peters, W. H., Hung, R. J., McLaughlin, J., Vatten, L., Njolstad, I., Goodman, G. E., Field, J. K., Liloglou, T., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Gonzalez, C. A., Quiros, J. R., Martinez, C., Navarro, C., Ardanaz, E., Larranaga, N., Khaw, K. T., Key, T., Bueno-de-Mesquita, H. B., Peeters, P. H., Trichopoulou, A., Linseisen, J., Boeing, H., Hallmans, G., Overvad, K., Tjonneland, A., Kumle, M., Riboli, E., Valk, K., Vooder, T., Metspalu, A., Zelenika, D., Boland, A., Delepine, M., Foglio, M., Lechner, D., Blanche, H., Gut, I. G., Galan, P., Heath, S., Hashibe, M., Hayes, R. B., Boffetta, P., Lathrop, M. and Brennan, P. (2011). A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet 7(3): e1001333.
  21. Daskalos, A., Oleksiewicz, U., Filia, A., Nikolaidis, G., Xinarianos, G., Gosney, J. R., Malliri, A., Field, J. K. and Liloglou, T. (2011). UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer. Cancer 117(5): 1027-1037.
  22. Daskalos, A., Logotheti, S., Markopoulou, S., Xinarianos, G., Gosney, J. R., Kastania, A. N., Zoumpourlis, V., Field, J. K. and Liloglou, T. (2011). Global DNA hypomethylation-induced DeltaNp73 transcriptional activation in non-small cell lung cancer. Cancer Lett 300(1): 79-86.
  23. Liloglou, T. and Field, J. K. (2010). Detection of DNA methylation changes in body fluids. Adv Genet 71: 177-207.
  24. Schache, A. G., Hall, G., Woolgar, J. A., Nikolaidis, G., Triantafyllou, A., Lowe, D., Risk, J. M., Shaw, R. J. and Liloglou, T. (2010). Quantitative promoter methylation differentiates carcinoma ex pleomorphic adenoma from pleomorphic salivary adenoma. Br J Cancer 103(12): 1846-1851.
  25. Bediaga, N. G., Acha-Sagredo, A., Guerra, I., Viguri, A., Albaina, C., Ruiz Diaz, I., Rezola, R., Alberdi, M. J., Dopazo, J., Montaner, D., Renobales, M., Fernandez, A. F., Field, J. K., Fraga, M. F., Liloglou, T. and de Pancorbo, M. M. (2010). DNA methylation epigenotypes in breast cancer molecular subtypes. Breast Cancer Res 12(5): R77.
  26. Schmidt, B., Liebenberg, V., Dietrich, D., Schlegel, T., Kneip, C., Seegebarth, A., Flemming, N., Seemann, S., Distler, J., Lewin, J., Tetzner, R., Weickmann, S., Wille, U., Liloglou, T., Raji, O., Walshaw, M., Fleischhacker, M., Witt, C. and Field, J. K. (2010). SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates. BMC Cancer 10: 600.
  27. Logotheti, S., Michalopoulos, I., Sideridou, M., Daskalos, A., Kossida, S., Spandidos, D. A., Field, J. K., Vojtesek, B., Liloglou, T., Gorgoulis, V. and Zoumpourlis, V. (2010). Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer. FEBS J 277(14): 3014-3027.
  28. Lips, E. H., Gaborieau, V., McKay, J. D., Chabrier, A., Hung, R. J., Boffetta, P., Hashibe, M., Zaridze, D., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Field, J. K., Liloglou, T., Xinarianos, G., McLaughlin, J., Liu, G., Skorpen, F., Elvestad, M. B., Hveem, K., Vatten, L., Study, E., Benhamou, S., Lagiou, P., Holcatova, I., Merletti, F., Kjaerheim, K., Agudo, A., Castellsague, X., Macfarlane, T. V., Barzan, L., Canova, C., Lowry, R., Conway, D. I., Znaor, A., Healy, C., Curado, M. P., Koifman, S., Eluf-Neto, J., Matos, E., Menezes, A., Fernandez, L., Metspalu, A., Heath, S., Lathrop, M. and Brennan, P. (2010). Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. Int J Epidemiol 39(2): 563-577.
  29. Field, J. K., Liloglou, T., Niaz, A., Bryan, J., Gosney, J. R., Giles, T., Brambilla, C., Brambilla, E., Vesin, A., Timsit, J. F., Hainaut, P., Martinet, Y., Vignaud, J. M., Thunnissen, F. B., Prinsen, C., Snijders, P. J., Smit, E. F., Sozzi, G., Roz, L., Risch, A., Becker, H. D., Elborn, J. S., Magee, N. D., Montuenga, L. M., Pajares, M. J., Lozano, M. D., O'Byrne, K. J., Harrison, D. J., Niklinski, J. and Cassidy, A. (2009). EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration. Eur Respir J 34(6): 1477-1486.
  30. Barh, D., Kumar, A., Chatterjee, S. and Liloglou, T. (2009). Molecular features, markers, drug targets, and prospective targeted therapeutics in cardiac myxoma. Curr Cancer Drug Targets 9(6): 705-716.
  31. Shaw, R. J., Omar, M. M., Rokadiya, S., Kogera, F. A., Lowe, D., Hall, G. L., Woolgar, J. A., Homer, J., Liloglou, T., Field, J. K. and Risk, J. M. (2009). Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. Br J Cancer 101(1): 139-144.
  32. Johnson, G. G., Sherrington, P. D., Carter, A., Lin, K., Liloglou, T., Field, J. K. and Pettitt, A. R. (2009). A novel type of p53 pathway dysfunction in chronic lymphocytic leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene. Cancer Res 69(12): 5210-5217.
  33. Cassidy, A., Balsan, J., Vesin, A., Wu, X., Liloglou, T., Brambilla, C., Timsit, J. F. and Field, J. K. (2009). Cancer diagnosis in first-degree relatives and non-small cell lung cancer risk: results from a multi-centre case-control study in Europe. Eur J Cancer 45(17): 3047-3053.
  34. Dunn, J., Baborie, A., Alam, F., Joyce, K., Moxham, M., Sibson, R., Crooks, D., Husband, D., Shenoy, A., Brodbelt, A., Wong, H., Liloglou, T., Haylock, B. and Walker, C. (2009). Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy. Br J Cancer 101(1): 124-131.
  35. Daskalos, A., Nikolaidis, G., Xinarianos, G., Savvari, P., Cassidy, A., Zakopoulou, R., Kotsinas, A., Gorgoulis, V., Field, J. K. and Liloglou, T. (2009). Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer. Int J Cancer 124(1): 81-87.
  36. Knight, L. J., Burrage, J., Bujac, S. R., Haggerty, C., Graham, A., Gibson, N. J., Ellison, G., Growcott, J. W., Brooks, A. N., Hughes, A. M., Xinarianos, G., Nikolaidis, G., Field, J. K. and Liloglou, T. (2009). Epigenetic silencing of the endothelin-B receptor gene in non-small cell lung cancer. Int J Oncol 34(2): 465-471.
  37. Verri, C., Roz, L., Conte, D., Liloglou, T., Livio, A., Vesin, A., Fabbri, A., Andriani, F., Brambilla, C., Tavecchio, L., Calarco, G., Calabro, E., Mancini, A., Tosi, D., Bossi, P., Field, J. K., Brambilla, E., Sozzi, G. and Consortium, E. (2009). Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project. Am J Respir Crit Care Med 179(5): 396-401.
Protocols by Triantafillos Liloglou
  1. Quantitative Methylation Specific PCR (qMSP)