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Subbareddy Maddika


Ph.D. in Biochemistry & Medical Genetics, University of Manitoba, Canada, 2007

Current position

Head of Laboratory of Cell Death & Cell Survival (LCDCS), Center for DNA Fingerprinting & Diagnostics (CDFD), Hyderabad


Research Articles

  1. Kavela, S., Shinde, S. R., Ratheesh, R., Viswakalyan, K., Bashyam, M. D., Gowrishankar, S., Vamsy, M., Pattnaik, S., Rao, S., Sastry, R. A., Srinivasulu, M., Chen, J. and Maddika, S. (2013). PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Res 73(1): 205-214.
  2. Jain, M. V., Paczulla, A. M., Klonisch, T., Dimgba, F. N., Rao, S. B., Roberg, K., Schweizer, F., Lengerke, C., Davoodpour, P., Palicharla, V. R., Maddika, S. and Los, M. (2013). Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J Cell Mol Med 17(1): 12-29.
  3. Maddika, S.@, Kavela, S., Rani, N., Palicharla, V. R., Pokorny, J. L., Sarkaria, J. N. and Chen, J. (2011). WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol 13(6): 728-733. (@ Corresponding author)
  4. Maddika, S. and Chen, J. (2009). Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol 11(4): 409-419.
  5. Maddika, S., Sy, S. M. and Chen, J. (2009). Functional interaction between Chfr and Kif22 controls genomic stability. J Biol Chem 284(19): 12998-13003.
  6. Maddika, S., Panigrahi, S., Wiechec, E., Wesselborg, S., Fischer, U., Schulze-Osthoff, K. and Los, M. (2009). Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Mol Cell Biol 29(5): 1235-1248.
  7. Ghavami, S., Eshraghi, M., Kadkhoda, K., Mutawe, M. M., Maddika, S., Bay, G. H., Wesselborg, S., Halayko, A. J., Klonisch, T. and Los, M. (2009). Role of BNIP3 in TNF-induced cell death--TNF upregulates BNIP3 expression. Biochim Biophys Acta 1793(3): 546-560.
  8. Maddika, S., Ande, S. R., Wiechec, E., Hansen, L. L., Wesselborg, S. and Los, M. (2008). Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis. J Cell Sci 121(Pt 7): 979-988.
  9. Maddika, S., Wiechec, E., Ande, S. R., Poon, I. K., Fischer, U., Wesselborg, S., Jans, D. A., Schulze-Osthoff, K. and Los, M. (2008). Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin. Oncogene 27(21): 3060-3065.
  10. Maddika, S., Bay, G. H., Kroczak, T. J., Ande, S. R., Maddika, S., Wiechec, E., Gibson, S. B. and Los, M. (2007). Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death. Cell Prolif 40(6): 835-848.
  11. Burek, M.*, Maddika, S.*, Burek, C. J., Daniel, P. T., Schulze-Osthoff, K. and Los, M. (2006). Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent. Oncogene 25(15): 2213-2222. (* Equal First Authorship)
  12. Maddika, S., Booy, E. P., Johar, D., Gibson, S. B., Ghavami, S. and Los, M. (2005). Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway. J Cell Sci 118(Pt 19): 4485-4493.
  13. Hashemi, M., Karami-Tehrani, F., Ghavami, S., Maddika, S. and Los, M. (2005). Adenosine and deoxyadenosine induces apoptosis in oestrogen receptor-positive and -negative human breast cancer cells via the intrinsic pathway. Cell Prolif 38(5): 269-285.
  14. Barczyk, K., Kreuter, M., Pryjma, J., Booy, E. P., Maddika, S., Ghavami, S., Berdel, W. E., Roth, J. and Los, M. (2005). Serum cytochrome c indicates in vivo apoptosis and can serve as a prognostic marker during cancer therapy. Int J Cancer 116(2): 167-173.


  1. Ande, S. R., Chen, J. and Maddika, S.# (2009). The ubiquitin pathway: an emerging drug target in cancer therapy. Eur J Pharmacol 625(1-3): 199-205. (#Corresponding author)
  2. Los, M., Maddika, S., Erb, B. and Schulze-Osthoff, K. (2009). Switching Akt: from survival signaling to deadly response. Bioessays 31(5): 492-495.
  3. Maddika, S., Ande, S. R., Panigrahi, S., Paranjothy, T., Weglarczyk, K., Zuse, A., Eshraghi, M., Manda, K. D., Wiechec, E. and Los, M. (2007). Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat 10(1-2): 13-29.
  4. Kroczak, T. J., Baran, J., Pryjma, J., Siedlar, M., Reshedi, I., Hernandez, E., Alberti, E., Maddika, S. and Los, M. (2006). The emerging importance of DNA mapping and other comprehensive screening techniques, as tools to identify new drug targets and as a means of (cancer) therapy personalisation. Expert Opin Ther Targets 10(2): 289-302.
  5. Maddika, S., Mendoza, F. J., Hauff, K., Zamzow, C. R., Paranjothy, T. and Los, M. (2006). Cancer-selective therapy of the future: apoptin and its mechanism of action. Cancer Biol Ther 5(1): 10-19.
  6. Pour-Jafari, H., Ghavami, S. and Maddika, S. (2005). Mitochondrial Physiology and Toxicity (Mitotoxicity); Importance for the Immune System, Programmed Cell Death and Cancer. Current Medicinal Chemistry-Anti-Inflammatory & Anti-Allergy Agents 4(4): 439-448.
  7. Kreuter, M., Langer, C., Kerkhoff, C., Reddanna, P., Kania, A. L., Maddika, S., Chlichlia, K., Bui, T. N. and Los, M. (2004). Stroke, myocardial infarction, acute and chronic inflammatory diseases: caspases and other apoptotic molecules as targets for drug development. Arch Immunol Ther Exp (Warsz) 52(3): 141-155.

Book Chapters

  1. Ghavami S., Barczyk K., Maddika S., Pourjafari H., Kroczak T., and Los, M. Monitoring of programmed cell death in vivo: new methods of cancer therapy monitoring. In: Apoptotic pathways as target for novel therapies in cancer and other diseases. Edited by M. Los & S.B Gibson; Kluwer Academic Press (2004) ISBN 0-387-23384-9.
  2. Banerji S., Ande SR., Maddika S., Banerji V., Rashedi I., Owens NW., Zuse A., Schweizer F. and Los M.“Peptides and peptidomimetics as cancer therapy sensitizing agents.” in: Sensitization of Cancer Cells to Chemo/Immuno/Radio Therapy. (2008) edited by: B. Bonavida; Humana Press, Inc. ISBN 1934115290.
Protocols by Subbareddy Maddika
  1. PTEN-lipid Binding Assay