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Pascale Durbec

Education

Ph.D. in Cell biology, Université de Provence (Aix--Marseille--I), 1992

Current position

Group leader at Institute of developmental Biology of Marseille Luminy. IBDML UMR6216. Campus de Luminy (Marseille) France. Team “stem cells for brain repair”    

Directeur de recherche CNRS

Publications (selected)

  1. Cayre, M., Courtes, S., Martineau, F., Giordano, M., Arnaud, K., Zamaron, A. and Durbec, P. (2013). Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination. Development 140(15): 3107-3117.
  2. Vernerey, J., Macchi, M., Magalon, K., Cayre, M. and Durbec, P. (2013). Ciliary neurotrophic factor controls progenitor migration during remyelination in the adult rodent brain. J Neurosci 33(7): 3240-3250.
  3. Ferent, J., Zimmer, C., Durbec, P., Ruat, M. and Traiffort, E. (2013). Sonic Hedgehog signaling is a positive oligodendrocyte regulator during demyelination. J Neurosci 33(5): 1759-1772.
  4. Magalon, K., Zimmer, C., Cayre, M., Khaldi, J., Bourbon, C., Robles, I., Tardif, G., Viola, A., Pruss, R. M., Bordet, T. and Durbec, P. (2012). Olesoxime accelerates myelination and promotes repair in models of demyelination. Ann Neurol 71(2): 213-226.
  5. Courtes, S., Vernerey, J., Pujadas, L., Magalon, K., Cremer, H., Soriano, E., Durbec, P.* and Cayre, M. (2011). Reelin controls progenitor cell migration in the healthy and pathological adult mouse brain. PLoS One 6(5): e20430. (* co last author.)
  6. Peyre, E., Jaouen, F., Saadaoui, M., Haren, L., Merdes, A., Durbec, P. and Morin, X. (2011). A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cells. J Cell Biol 193(1): 141-154.
  7. Popa, N., Cedile, O., Pollet-Villard, X., Bagnis, C., Durbec, P. and Boucraut, J. (2011). RAE-1 is expressed in the adult subventricular zone and controls cell proliferation of neurospheres. Glia 59(1): 35-44.
  8. Cantarella, C., Cayre, M., Magalon, K. and Durbec, P. (2008). Intranasal HB-EGF administration favors adult SVZ cell mobilization to demyelinated lesions in mouse corpus callosum. Dev Neurobiol 68(2): 223-236.
  9. Morin, X., Jaouen, F. and Durbec, P. (2007). Control of planar divisions by the G-protein regulator LGN maintains progenitors in the chick neuroepithelium. Nat Neurosci 10(11): 1440-1448.
  10. Magalon, K., Cantarella, C., Monti, G., Cayre, M. and Durbec, P. (2007). Enriched environment promotes adult neural progenitor cell mobilization in mouse demyelination models. Eur J Neurosci 25(3): 761-771.
  11. Cayre, M., Bancila, M., Virard, I., Borges, A. and Durbec, P. (2006). Migrating and myelinating potential of subventricular zone neural progenitor cells in white matter tracts of the adult rodent brain. Mol Cell Neurosci 31(4): 748-758.
  12. Virard, I., Coquillat, D., Bancila, M., Kaing, S. and Durbec, P. (2006). Oligodendrocyte precursor cells generate pituicytes in vivo during neurohypophysis development. Glia 53(3): 294-303.
  13. Franceschini, I., Vitry, S., Padilla, F., Casanova, P., Tham, T. N., Fukuda, M., Rougon, G., Durbec, P. and Dubois-Dalcq, M. (2004). Migrating and myelinating potential of neural precursors engineered to overexpress PSA-NCAM. Mol Cell Neurosci 27(2): 151-162.
  14. Zhang, H., Vutskits, L., Calaora, V., Durbec, P. and Kiss, J. Z. (2004). A role for the polysialic acid-neural cell adhesion molecule in PDGF-induced chemotaxis of oligodendrocyte precursor cells. J Cell Sci 117(Pt 1): 93-103.
  15. Durbec, P. and Rougon, G. (2001). Transplantation of mammalian olfactory progenitors into chick hosts reveals migration and differentiation potentials dependent on cell commitment. Mol Cell Neurosci 17(3): 561-576.
  16. Chazal, G., Durbec, P., Jankovski, A., Rougon, G. and Cremer, H. (2000). Consequences of neural cell adhesion molecule deficiency on cell migration in the rostral migratory stream of the mouse. J Neurosci 20(4): 1446-1457.
  17. Durbec, P., Marcos-Gutierrez, C. V., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M. and et al. (1996). GDNF signalling through the Ret receptor tyrosine kinase. Nature 381(6585): 789-793.
Protocols by Pascale Durbec
  1. Primary Culture of SVZ-derived Progenitors Grown as Neurospheres